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Tumor necrosis factor-α 238 G/A polymorphism and gastric cancer risk: a meta-analysis

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Tumor Biology

Abstract

Though many studies were performed to assess the association between tumor necrosis factor-α (TNF-α) 238 G/A polymorphism and gastric cancer risk, there were no conclusive findings. A meta-analysis of previous published studies was performed to get a comprehensive assessment of the association between TNF-α 238 G/A polymorphisms and gastric cancer. The pooled odds ratios (ORs) and 95 % confidence intervals (95 % CIs) were calculated to assess the association. Fifteen studies with a total of 7,795 participants were finally included into this meta-analysis. Overall, there was an obvious association between TNF-α 238 G/A polymorphism and increased risk of gastric cancer (A vs. G: OR = 1.32, 95 % CI 1.02–1.72, P = 0.036; GA vs. GG: OR = 1.32, 95 % CI 1.01–1.72, P = 0.042; and AA/GA vs. GG: OR = 1.34, 95 % CI 1.02–1.76, P = 0.036). Subgroup analysis by ethnicity showed the statistically significant association between TNF-α 238 G/A polymorphism and gastric cancer was limited to Asian populations (A vs. G: OR = 1.59, 95 % CI 1.29–1.97, P < 0.001; GA vs. GG: OR = 1.63, 95 % CI 1.29–2.04, P < 0.001; and AA/GA vs. GG: OR = 1.64, 95 %CI 1.31–2.05, P < 0.001), and there was no obvious association in Caucasians. In conclusion, TNF-α 238 G/A polymorphism is significantly associated with increased risk of gastric cancer, especially in Asians.

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Authors and Affiliations

  1. Department of Gastrointestinal Surgery, Shandong Cancer Hospital, Jinan, 250117, China

    Jian-yong Yu, Heng Ma, Kai Liu, Xurui Cheng, Yan-liang Li & Xi-lin Song

  2. Department of Trauma Surgery, Wendeng Osteopathic Hospital, Wendeng, Shandong Province, China

    Li Li

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  1. Jian-yong Yu
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  2. Li Li
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Correspondence to Xi-lin Song.

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Jian-yong Yu and Li Li contributed equally to the study.

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Yu, Jy., Li, L., Ma, H. et al. Tumor necrosis factor-α 238 G/A polymorphism and gastric cancer risk: a meta-analysis. Tumor Biol. 34, 3859–3863 (2013). https://doi.org/10.1007/s13277-013-0972-z

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  • DOI: https://doi.org/10.1007/s13277-013-0972-z

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