Abstract
An elevated plasma D-dimer level indicates the activation of coagulation and fibrinolysis. Several studies suggested that high level of plasma D-dimer was associated with the prognosis of lung cancer. In the present study, we performed a meta-analysis to evaluate the relationship between plasma D-dimer level and the prognosis of lung cancer based on larger sample size. We retrieved the literature, assessed and selected the data, and performed the statistical analysis according to the RevMan 5.0 guidelines. Literature-based searching was guided to gather data, and fixed-effects model was used to pool the hazard ratio according to the test of heterogeneity. A total of seven eligible studies including 1,377 lung cancer patients were analyzed. Survival time was significantly better in patients in the low D-dimer group than those in the high D-dimer group (hazard ratio for high D-dimer group = 1.12; 95 % confidence interval 1.02 to 1.23). Patients with high levels of D-dimer have a poorer overall survival compared with those patients with low levels of D-dimer.
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Kamikura Y, Wada H, Sase T, Yamaguchi M, Kaneko T, Sakaguchi A, et al. Hemostatic abnormalities and leukocyte activation caused by infection in patients with malignant lymphoma during chemotherapy. Thromb Res. 2006;117(6):671–9.
Kalweit GA, Feindt P, Micek M, Gams E, Hellstern P. Markers of activated hemostasis and fibrinolysis in patients with pulmonary malignancies: comparison of plasma levels in central venous and pulmonary venous blood. Thromb Res. 2000;97(3):105–11.
Lu WX, Li LY, Gao Y, et al. Thrombosis diseases and lung cancer. Chin J Tubere Respir Dis. 2000;23(7):400–2.
Zhang JX, Cui CB. The clinical analysis of 18 patients with lung cancer complicated with venous thromboembolism. Chin J Lung Cancer. 2006;9(6):550–1.
Komurcuoglu B, Ulusoy S, Gayaf M, Guler A, Ozden E. Prognostic value of plasma D-dimer levels in lung carcinoma. Tumori. 2011;97(6):743–8.
Altiay G, Ciftci A, Demir M, Kocak Z, Sut N, Tabakoglu E, et al. High plasma D-dimer level is associated with decreased survival in patients with lung cancer. Clin Oncol (R Coll Radiol). 2007;19(7):494–8.
Buccheri G, Torchio P, Ferrigno D. Plasma levels of D-dimer in lung carcinoma: clinical and prognostic significance. Cancer. 2003;97(12):3044–52.
Taguchi O, Gabazza EC, Yasui H, Kobayashi T, Yoshida M, Kobayashi H. Prognostic significance of plasma D-dimer levels in patients with lung cancer. Thorax. 1997;52(6):563–5.
Ay C, Dunkler D, Marosi C, Chiriac AL, Vormittag R, Simanek R, et al. Prediction of venous thromboembolism in cancer patients. Blood. 2010;116(24):5377–82.
Wang Z, Fu JK, Diao DM, et al. Plasma D-dimer level in the perioperative period in non-small-cell lung cancer. Thoracic Cancer. 2011;2:207–12.
Coskun F, Yilmaz D, Ursavas A, Uzaslan E, Ege E. Relationship between disease severity and D-dimer levels measured with two different methods in pulmonary embolism patients. Multidiscip Respir Med. 2010;5(3):168–72.
Beer JH, Haeberli A, Vogt A, et al. Coagulation markers predict survival in cancer patients. Thromb Haemost. 2002;88:745–9.
Buccheri G, Torchio P, Ferrigno P. Plasma levels of D-dimer in lung carcinoma- clinical and prognostic significance. Cancer. 2002;97:3044–52.
Unsul E, Atalav F, Atikcan S, Yilmaz A. Prognostic significance of hemostatic parameters in patients with lung cancer. Respir Med. 2004;98:93–8.
Gabazza EC, Taguchi O, Yamakami T, Machishi M, Ibata H, Suzuki S. Evaluating the prethrombotic state in lung cancer using molecular markers. Chest. 1993;103:196–200.
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Yong-Xin Zhou and Zhong-Min Yang have contributed equally to this work.
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Zhou, YX., Yang, ZM., Feng, J. et al. High plasma D-dimer level is associated with decreased survival in patients with lung cancer: a meta-analysis. Tumor Biol. 34, 3701–3704 (2013). https://doi.org/10.1007/s13277-013-0953-2
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DOI: https://doi.org/10.1007/s13277-013-0953-2