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RETRACTED ARTICLE: Matrix metalloproteinase 9 expression and prognosis in colorectal cancer: a meta-analysis

  • Research Article
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Tumor Biology

This article was retracted on 20 April 2017

Abstract

Matrix metalloproteinase-9 (MMP-9) is an important member of the matrix metalloproteinase family and is considered to be involved in the invasion and metastasis of cancer cells. Many studies were published to assess the prognostic role of MMP-9 overexpression in patients with colorectal cancer, but the findings from those studies were inconsistent. We searched eligible studies in Pubmed, Embase, and Web of Science databases. Thirteen studies with a total of 2, 390 CRC patients were finally included into the meta-analysis. The pooled hazard ratios (HRs) with the corresponding 95 % confidence interval (95 % CIs) for overall and progression-free survival were calculated by using meta-analysis. There were nine studies with a total of 1,674 colorectal cancer patients relating the progression-free survival, and eight studies with a total of 1,379 colorectal cancer patients relating the overall survival. Overall, MMP-9 overexpression was associated with poorer progression-free survival in patients with colorectal cancer (fixed-effects HR 1.81, 95 % CI 1.48–2.20, P < 0.001; random-effects HR 1.92, 95 % CI 1.46–2.53, P < 0.001). In addition, MMP-9 overexpression was also associated with poorer overall survival in patients with colorectal cancer (fixed-effects HR 1.74, 95 % CI 1.39–2.19, P < 0.001; random-effects HR 1.78, 95 % CI 1.31–2.41, P < 0.001). MMP-9 expression is associated with the prognosis of patients with colorectal cancer, and patients with higher MMP-9 expression have poorer survival.

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Authors and Affiliations

  1. Anorectal Department, The Fourth Affiliated Hospital of China Medical University, Chongshan East Road No. 4, Huanggu District, Shenyang, 110032, China

    Chun-Yu Li, Peng Yuan, Shu-Sen Lin, Cheng-Fei Song, Wei-Yu Guan, Lu Yuan, Rong-Bin Lai & Yan Wang

  2. Department of Pathology, The Fourth Affiliated Hospital of China Medical University, Shenyang, 110032, China

    Ying Gao

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  1. Chun-Yu Li
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  2. Peng Yuan
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  3. Shu-Sen Lin
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  4. Cheng-Fei Song
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  9. Yan Wang
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Correspondence to Chun-Yu Li or Ying Gao.

Additional information

The Publisher and Editor retract this article in accordance with the recommendations of the Committee on Publication Ethics (COPE). After a thorough investigation we have strong reason to believe that the peer review process was compromised.

An erratum to this article can be found online at http://dx.doi.org/10.1007/s13277-017-5487-6.

An erratum to this article is available at http://dx.doi.org/10.1007/s13277-017-5487-6.

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Li, CY., Yuan, P., Lin, SS. et al. RETRACTED ARTICLE: Matrix metalloproteinase 9 expression and prognosis in colorectal cancer: a meta-analysis. Tumor Biol. 34, 735–741 (2013). https://doi.org/10.1007/s13277-012-0601-2

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  • DOI: https://doi.org/10.1007/s13277-012-0601-2

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