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MMP-7 as a prognostic marker in colorectal cancer

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Tumor Biology

Abstract

Matrix metalloproteinase-7 is capable of degrading many extracellular matrix proteins and cellular adhesions. In many malignancies, it is overexpressed, and it plays a role in cancer progression by enhancing tumor invasion and thereby metastatic potential. The purpose of this study was to evaluate the association between MMP-7 tissue expression and prognosis in colorectal cancer. From 623 patients who underwent surgery for colorectal cancer, surgical specimens were collected into tissue array blocks and stained by immunohistochemistry for MMP-7. Specimens from 545 patients were suitable for analysis. In specimens from 105 patients (19.3%), MMP-7 scored as high; in 103 (18.9%), as moderate; and in 134 (24.9%), as mild. In 203 cases (37.2%), immunoreactivity was negative. A significant correlation appeared between MMP-7 immunoexpression and tumor differentiation. High MMP-7 positivity associated with poor prognosis during a 5-year follow-up. During longer follow-up, the differences in survival between groups disappeared. MMP-7 is a potential target for tumor therapy, which should be evaluated in clinical trials.

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Acknowledgements

We thank Päivi Peltokangas, Tuire Koski, and Elina Aspiala for technical assistance.

Funding

This study was supported by Finska Läkaresällskapet, Medicinska Understödsföreningen Liv och Hälsa, and the Sigrid Jusélius Foundation.

Ethics approval

The study has been approved by local ethics committee and complies with the Declaration of Helsinki (Dnro HUS 226/E6/06).

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Authors and Affiliations

  1. Department of Surgery, Helsinki University Central Hospital, P.O. Box 340, 00029 HUS, Helsinki, Finland

    Selja Koskensalo, Johanna Louhimo & Caj Haglund

  2. Department of Pathology, Helsinki University Central Hospital, Helsinki, Finland

    Stig Nordling, Jaana Hagström & Caj Haglund

Authors
  1. Selja Koskensalo
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  2. Johanna Louhimo
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  3. Stig Nordling
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  4. Jaana Hagström
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  5. Caj Haglund
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Corresponding author

Correspondence to Caj Haglund.

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Koskensalo, S., Louhimo, J., Nordling, S. et al. MMP-7 as a prognostic marker in colorectal cancer. Tumor Biol. 32, 259–264 (2011). https://doi.org/10.1007/s13277-010-0080-2

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  • DOI: https://doi.org/10.1007/s13277-010-0080-2

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