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Clinicopathological characteristics and prognostic analysis of gastric cancer in the young adult in China

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Tumor Biology

Abstract

The incidence of gastric cancer in young has increased steadily in the last decades. Little is known about the clinicopathologic features and prognostic factors of young adult gastric cancer patients. The clinicopathological characteristics of 294 young adult gastric cancer patients between 20 and 50 years old were reviewed retrospectively from hospital records in Sun Yat-Sen University Cancer Center between 1996 and 2006. They were compared with 706 elder patients 51 years of age or over. A steady increasing in the proportion of female in the gastric carcinoma patients as the age decreasing was found. The distinguishing histological features of young adult patients were higher percentage of poorly differentiated grade and distant metastasis. The distribution of tumor–nodes–metastasis (TNM) stage was similar between these two groups. The 5-year disease-specific survival rate in the young adult group was significantly higher than in the elderly group. More patients receiving adjuvant chemotherapy were found in the young adult group. Multivariable analysis demonstrated that TNM stage and presence of angiolymphatic invasion were the independent negative predictors of survival for young patients with gastric cancer. Gastric cancer in young patients differs from that in elderly patients including a lack of male predilection, more aggressive histologic features, and better survival rate.

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Acknowledgements

We gratefully thank the staff members in the Department of Medical Oncology and GI Surgery Oncology at Sun Yat-sen University Cancer Center for their suggestion and assistance.

Funding

This work was supported by National Natural Science Foundation of China grant 30672408, Guangzhou Bureau of Science and Technology grant 2006Z3-E0041 and Sun Yat-sen University 985 Program Initiation Fund (China).

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None

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Authors and Affiliations

  1. State Key Laboratory of Oncology in South China, Guangzhou, 510060, China

    Miao-zhen Qiu, Zhi-qiang Wang, Dong-sheng Zhang, Hui-yan Luo, Zhi-wei Zhou, Feng-hua Wang, Yu-hong Li, Wen-qi Jiang & Rui-hua Xu

  2. Department of Medical Oncology, Sun Yat-Sen University Cancer Center, 651 Dong Feng Road East, Guangzhou, 510060, China

    Miao-zhen Qiu, Zhi-qiang Wang, Dong-sheng Zhang, Hui-yan Luo, Feng-hua Wang, Yu-hong Li, Wen-qi Jiang & Rui-hua Xu

  3. Department of Gastric and Pancreatic Surgery, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, China

    Zhi-wei Zhou

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  1. Miao-zhen Qiu
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  2. Zhi-qiang Wang
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  3. Dong-sheng Zhang
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  4. Hui-yan Luo
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  9. Rui-hua Xu
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Corresponding author

Correspondence to Rui-hua Xu.

Additional information

The study was conducted in the Medical Oncology Department, Sun Yat-Sen University Cancer Center.

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Qiu, Mz., Wang, Zq., Zhang, Ds. et al. Clinicopathological characteristics and prognostic analysis of gastric cancer in the young adult in China. Tumor Biol. 32, 509–514 (2011). https://doi.org/10.1007/s13277-010-0145-2

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  • DOI: https://doi.org/10.1007/s13277-010-0145-2

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