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Clinicopathological characteristics, survival outcome and prognostic factors of very young gastric cancer

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Abstract

To explore the clinicopathological characteristics, survival outcomes, and prognosis of very young gastric cancer (GC). From January 1, 2011 to January 1, 2021, GC patients under 30 years old treated in three tertiary hospitals were enrolled. Clinicopathological characteristics were summarized, prognostic factors and survival outcomes including overall survival (OS), disease-free survival (DFS), and progression-free survival (PFS) were retrospectively analyzed. One hundred patients were finally included, with a median age of 23 years.73 (73.0%) were female. Most patients had initial symptoms of abdominal pain (66.0%). The most common tumor locations were gastric antrum (38.0%) and gastric body (37.0%). The main histological types were diffuse (81.0%) and poorly differentiated (91.0%). Most patients presented with stage III–IV disease (82.0%) at diagnosis and the common sites of metastasis were ovary (39.5%) and peritoneum (27.6%). The mOS of the whole group was 23.3 months (95% CI 17.2–29.4). Moreover, the mOS of patients at stage I–II was not reached. The mOS of patients at stage III and stage IV was 40.6 months (95% CI 10.2–70.9) and 10.3 months (95% CI 8.9–11.6), respectively. The mDFS of stage I–III patients was 28.5 months (95% CI 14.7–42.3), and the mPFS of the metastatic patients was 4.5 months (95% CI 4.0–5.0). TNM stage (P = 0.005) and radical surgery (P = 0.001) were independent prognostic factors of overall survival. The very young GC were predominantly female, diffuse type, and advanced diagnosis. TNM stage and radical surgery were independent prognosis factors for overall survival.

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Funding

The authors declare that no funds, grants, or other support were received during the preparation of this manuscript.

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Author notes

  1. Niuniu Zhong, Yi Yu, and Jun Chen have contributed equally to this work.

Authors and Affiliations

  1. Department of Oncology, The First Affiliated Hospital, Nanchang University, Nanchang, 330006, Jiangxi, China

    Niuniu Zhong, Yi Yu, Jun Chen & Junhe Li

  2. Department of General Practice, The Second Affiliated Hospital, Nanchang University, Nanchang, 330008, Jiangxi, China

    Yuanyuan Shao

  3. Department of Oncology, Jiangxi Tumor Hospital, Nanchang University, Nanchang, 330029, Jiangxi, China

    Zhiqiang Peng

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  1. Niuniu Zhong
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  2. Yi Yu
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  6. Junhe Li
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Contributions

All authors contributed to the study conception and design. The idea of the study was put forward by JL; Data collection and analysis and the first draft of the manuscript were performed by NZ. The manuscript was revised and polished by YY and JC; YS and ZP contributed to date collection. All authors read and approved the final manuscript.

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Correspondence to Junhe Li.

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The authors have no relevant financial or non-financial interests to disclose.

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The ethical committee of each hospital approved the study and informed consents were obtained from all the patients.

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Zhong, N., Yu, Y., Chen, J. et al. Clinicopathological characteristics, survival outcome and prognostic factors of very young gastric cancer. Clin Exp Med 23, 437–445 (2023). https://doi.org/10.1007/s10238-022-00822-3

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  • DOI: https://doi.org/10.1007/s10238-022-00822-3

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