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MMP-7 overexpression is an independent prognostic marker in gastric cancer

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Tumor Biology

Abstract

To enable cancer to invade and to metastasize, the surrounding stroma must be degraded. Matrix metalloproteinase-7 (MMP-7) is capable of degrading many extracellular matrix proteins and cellular adhesions, is overexpressed in many malignancies, and plays a role in tumour progression. The purpose of this study was to evaluate the association between MMP-7 tissue expression and patients’ prognosis in gastric cancer. From 264 patients who underwent surgery for gastric cancer, surgical specimens were collected on tissue array blocks and stained by immunohistochemistry for MMP-7. In 27 (10.2%) of the specimens, immunopositivity was found as high, in 50 (18.9%) as moderate and in 51 (19.3%) as weak. In 136 cases (51.5%), the immunopositivity was negative. A statistically significant correlation appeared between high MMP-7 expression and poor survival. In conclusion, our results suggest that MMP-7 expression may prove helpful in evaluating gastric cancer prognosis.

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Acknowledgements

We thank Päivi Peltokangas, Tuire Koski, and Elina Aspiala for excellent technical assistance.

This study was supported by Finska Läkaresällskapet, Medicinska Understödsföreningen Liv och Hälsa, and the Sigrid Juselius Foundation.

Ethics approval

The study has been approved by local ethical committee and the study complies with the Declaration of Helsinki (Dnro HUS 226/E6/06).

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Authors and Affiliations

  1. Department of Surgery, Helsinki University Central Hospital, P.O. Box 340, 00029, HUS, , Helsinki, Finland

    Selja Koskensalo, Johanna Mrena, Jan-Patrik Wiksten, Arto Kokkola & Caj Haglund

  2. Department of Pathology, Helsinki University Central Hospital, Helsinki, Finland

    Stig Nordling, Jaana Hagström & Caj Haglund

Authors
  1. Selja Koskensalo
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  2. Johanna Mrena
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  3. Jan-Patrik Wiksten
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  4. Stig Nordling
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  5. Arto Kokkola
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  6. Jaana Hagström
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  7. Caj Haglund
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Corresponding author

Correspondence to Caj Haglund.

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Koskensalo, S., Mrena, J., Wiksten, JP. et al. MMP-7 overexpression is an independent prognostic marker in gastric cancer. Tumor Biol. 31, 149–155 (2010). https://doi.org/10.1007/s13277-010-0020-1

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  • DOI: https://doi.org/10.1007/s13277-010-0020-1

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