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Toxicology study with microRNA

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Abstract

microRNAs have a principal role in many biological processes, such as gene expression, control and development, as well as cellular processes. In recent years, microRNAs have attracted great interest in the field of toxicology. When organisms are exposed to toxic compounds, microRNAs expression is altered, which affects mRNA transcription and protein translation and causes adverse biological effects. Here, we introduce microRNAs as research tools, the specific expression profile of microRNAs following exposure to different toxicants or diseases that were found to be sensitive biomarkers. Finally, we address several issues related to microRNAs in toxicological studies.

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  1. Yu Ri An

    Present address: Daewoong pharmaceutical, Seoul, Korea

Authors and Affiliations

  1. Department of Biochemistry, Hanyang University, Sangnok-gu, Ansan, Gyeonggi-do, Korea

    Yu Ri An & Seung Yong Hwang

  2. Department of Bionanotechnology, Hanyang University, Sangnok-gu, Ansan, Gyeonggi-do, Korea

    Seung Yong Hwang

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Correspondence to Seung Yong Hwang.

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An, Y.R., Hwang, S.Y. Toxicology study with microRNA. Mol. Cell. Toxicol. 10, 127–134 (2014). https://doi.org/10.1007/s13273-014-0014-y

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