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The effects of TiO2 nanoparticles on the protein expression in mouse lung

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Abstract

In this study, the differentially expressed proteins by titanium dioxide nanoparticles (TiO2 NPs) in mouse lung were examined via proteomic approach to better understand the molecular mechanism by which TiO2 NPs could induce toxicities at the protein level. We identified eight proteins that exhibited more than two-fold changes in expression by TiO2 NPs. Of these, five proteins, named cytoplasmic aconitase, L-lactate dehydrogenase A chain, carbonic anhydrase 1, pyruvate kinase isoform M2 and peroxiredoxin 6 displayed increased intensities in TiO2 NP-exposed lungs, while three proteins, named heat shock protein, moesin and apolipoprotein A-1 precursor, showed reduced intensities.

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Authors and Affiliations

  1. Department of Medical Biotechnology, Soonchunhyang University, Asan, 336-745, Korea

    Yu-Mi Jeon, Seul-Ki Park & Mi-Young Lee

  2. Department of Life Science, Soonchunhyang University, Asan, 336-745, Korea

    Wan-Jong Kim

  3. Department of Health Management, Hanseo University, Seosan, 360-706, Korea

    Joo-Hyun Ham

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  1. Yu-Mi Jeon
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  2. Seul-Ki Park
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  3. Wan-Jong Kim
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  4. Joo-Hyun Ham
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  5. Mi-Young Lee
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Correspondence to Mi-Young Lee.

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Jeon, YM., Park, SK., Kim, WJ. et al. The effects of TiO2 nanoparticles on the protein expression in mouse lung. Mol. Cell. Toxicol. 7, 283–289 (2011). https://doi.org/10.1007/s13273-011-0034-9

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  • DOI: https://doi.org/10.1007/s13273-011-0034-9

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