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Proteomic profiling of the differentially expressed proteins by TiO2 nanoparticles in mouse kidney

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Abstract

We investigated the proteins showing differential expression in response to TiO2 nanoparticles in mouse kidney using a proteomic approach to better understand the molecular mechanism by which TiO2 nanoparticles-induced nephrotoxicity at the protein level. More than 1,100 protein spots in mouse kidney were detected by the two-dimensional gel eletrophoresis and comparative analysis revealed that the expression of 11 proteins were changed by more than 2 fold in response to TiO2 nanoparticles. Of these, 10 were up-regulated and 1 was down-regulated upon treatment with TiO2 nanoparticles.

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Authors and Affiliations

  1. Department of Medical Biotechnology, SoonChunHyang University, Asan, Chungnam, 336-600, Korea

    Yu-Mi Jeon, Seul-Ki Park, Sang-Ki Rhee & Mi-Young Lee

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  1. Yu-Mi Jeon
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  2. Seul-Ki Park
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  3. Sang-Ki Rhee
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  4. Mi-Young Lee
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Correspondence to Mi-Young Lee.

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Jeon, YM., Park, SK., Rhee, SK. et al. Proteomic profiling of the differentially expressed proteins by TiO2 nanoparticles in mouse kidney. Mol. Cell. Toxicol. 6, 414–420 (2010). https://doi.org/10.1007/s13273-010-0055-9

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  • DOI: https://doi.org/10.1007/s13273-010-0055-9

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