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Poly(ethylene glycol) Composite Hydrogels with Natural Zeolite as Filler for Controlled Delivery Applications

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Abstract

In this study, composite hydrogels based on crosslinked polyethylene glycol diacrylate (PEGDA) and natural zeolite, with potential applications for the controlled release of phytoextracts, were synthesized by radical polymerization and characterized herein for the first time. The influence of various synthesis parameters, such as the use of distilled water or rose hip extract as reaction medium, or the percentage of the zeolite in the composite hydrogel upon the morphology, swelling kinetics and the rheological properties was investigated. By conducting polymerization of PEGDA in the rose hip extract, the crosslinking reaction yield was almost 100%, because of the chain transfer reactions of the polyphenols from the rose hip extract. Rose hip release tests were used to evaluate the release profiles of the natural bioactive substances from phytoextracts. The results showed that the hydrogel loaded with 3% zeolite displayed the lowest burst release and the slowest release rates of the extract.

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Author notes

  1. These authors equally contributed to this work.

Authors and Affiliations

  1. Advanced Polymer Materials and Polymer Recycling Group, National Institute for Research&Development in Chemistry and Petrochemistry-ICECHIM, 202 Spl. Independentei, 060021, Bucharest, Romania

    Bogdan Cursaru, Anita-Laura Radu, Andrei Sarbu, Ana-Mihaela Gavrilă, Teodor Sandu, Tanta-Verona Iordache & Anamaria Zaharia

  2. Laboratoire MAPIEM EA 4323 SeaTech-Ecole d’ingénieurs, Université de Toulon, BP 20132, 83957, La Garde, Cedex, France

    François-Xavier Perrin & Mircea Teodorescu

  3. Faculty of Applied Chemistry and Materials Science, University POLITEHNICA of Bucharest, Department of Bioresources and Polymer Science, 1-7 Polizu Street, 011061, Bucharest, Romania

    Celina-Maria Damian

Authors
  1. Bogdan Cursaru
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  2. Anita-Laura Radu
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Correspondence to Tanta-Verona Iordache or Anamaria Zaharia.

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Acknowledgments: The financial support of the Executive Unit for Financing Higher Education, Research, Development and Innovation (UEFISCDI), Ministry of National Education (ROMANIA) through the Romanian Research Projects PN III-Human Resources Programme-YOUNG RESEARCH TEAMS-PN-III-P1-1.1-TE-2016-1876, grant no. 91/02.05.2018-PLANano and PCCDI contract no. 39/2018-INTELMAT.

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Cursaru, B., Radu, AL., Perrin, FX. et al. Poly(ethylene glycol) Composite Hydrogels with Natural Zeolite as Filler for Controlled Delivery Applications. Macromol. Res. 28, 211–220 (2020). https://doi.org/10.1007/s13233-020-8029-9

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  • DOI: https://doi.org/10.1007/s13233-020-8029-9

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