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Swelling behavior and drug release of poly(vinyl alcohol) hydrogel cross-linked with poly(acrylic acid)

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Abstract

Thermal cross-linking method of poly(vinyl alcohol) (PVA) using poly(acrylic acid) (PAA) was carried out on PVA/PAA hydrogels. The level of gelation was measured in the PVA/ PAA hydrogels with various PAA contents. The swelling behavior at various pHs showed that the swelling kinetics and water contents of the PVA/ PAA hydrogels reached equilibrium after 30 h, and the time to reach the equilibrium state decreased with increasing PAA content in the hydrogel. The water content increased with increasing pH of the buffer solution. The permeation and release of the drug were tested using indomethacin as a model drug. The permeated and released amounts of the drug increased with decreasing the PAA content because of the low free volume in the hydrogel due to the higher cross-linking density. The kinetic profile of drug release at various pHs showed that all samples reached the equilibrium state within the 5 h.

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Authors and Affiliations

  1. Department of Chemical System Engineering, Keimyung University, 704-701, Daegu, Korea

    Hongsik Byun & Byungpyo Hong

  2. Department of Polymer Science and Engineering, Engineering Research Institute, i-Cube Center, Gyeongsang National University, 660-701, Jinju, Korea

    Sang Yong Nam

  3. Department of Chemical Engineering and Nano-Bio Technology, Hannam University, 305-811, Daejeon, Korea

    Sun Young Jung & Ji Won Rhim

  4. Clean System Team, Korea Institute of Industrial Technology, 330-825, Chungcheongnam-do, Korea

    Sang Bong Lee

  5. CRD, Research Park, LG Chem., 305-380, Daejeon, Korea

    Go Young Moon

Authors
  1. Hongsik Byun
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  2. Byungpyo Hong
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  3. Sang Yong Nam
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  4. Sun Young Jung
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  5. Ji Won Rhim
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  6. Sang Bong Lee
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  7. Go Young Moon
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Correspondence to Ji Won Rhim.

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Byun, H., Hong, B., Nam, S.Y. et al. Swelling behavior and drug release of poly(vinyl alcohol) hydrogel cross-linked with poly(acrylic acid). Macromol. Res. 16, 189–193 (2008). https://doi.org/10.1007/BF03218851

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  • DOI: https://doi.org/10.1007/BF03218851

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