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Collagen α-tocopherulate for topical applications: Preparation, characterization, and antioxidant activity evaluation

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Abstract

The aim of this work was to synthesize collagen α-tocopherulate for topical treatments. Collagen is a natural polymer largely applied to enhance wound repair, and α-tocopherol is a known antioxidant used for the treatment of various skin diseases. Linking the two through covalent bonds could improve α-tocopherol transport and metabolic stability, reduce the rate of degradation, and ensure a longer persistence than free antioxidant. The new biopolymer was prepared by a solid-phase synthesis employing a carboxypolystyrene resin. Its antioxidant activity in rat liver microsomal membranes was also evaluated. The obtained collagen-based biomaterial represents a new prodrug of α-tocopherol that could be used for various biomedical applications.

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Authors and Affiliations

  1. Department of Pharmaceutical Sciences, University of Calabria, 87036, Arcavacata di Rende, Cosenza, Italy

    Sonia Trombino, Roberta Cassano, Teresa Ferrarelli & Nevio Picci

  2. Department of Pharmaceutical Sciences, University of Florence, I-50019, Sesto Fiorentino, Firenze, Italy

    Benedetta Isacchi & Anna Rita Bilia

Authors
  1. Sonia Trombino
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  2. Roberta Cassano
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  3. Teresa Ferrarelli
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  4. Benedetta Isacchi
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  5. Anna Rita Bilia
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  6. Nevio Picci
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Correspondence to Roberta Cassano.

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Trombino, S., Cassano, R., Ferrarelli, T. et al. Collagen α-tocopherulate for topical applications: Preparation, characterization, and antioxidant activity evaluation. Macromol. Res. 20, 939–943 (2012). https://doi.org/10.1007/s13233-012-0129-8

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  • DOI: https://doi.org/10.1007/s13233-012-0129-8

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