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Synthesis of PEO-based block copolymers bearing cyclic hydrazide or carboxylic acid moieties and their applications as stabilizers for Fe3O4 nanoparticles

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Abstract

In this paper, a useful synthetic method for poly(ethylene oxide)-based block copolymers and their applications for preparation of iron oxide nanoparticles were introduced. Poly(ethylene oxide-b-N-phenylmaleimide) was first synthesized by anionic block copolymerization of ethylene oxide and N-phenylmaleimide (N-PMI) using mixed alkali metal alkoxides via the sequential monomer addition technique in a mixture of benzene dimethylsulfoxide (DMSO)/tetrahydrofuran (THF) (30/5/6∼20, v/v/v) at room temperature. Reductive deimidation of the resulting block copolymers under different reaction conditions using hydrazine monohydrate led to the formation of the corresponding water-soluble poly(ethylene oxide-b-maleic hydrazide) under acidic conditions and poly(ethylene oxideb-maleic acid) under basic conditions. Both were found to be very efficient stabilizers to prepare superparamagnetic iron oxide nanoparticles.

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Authors and Affiliations

  1. Department of Chemistry, Kyung Hee University, Seoul, 130-701, Korea

    Jinheung Kim, Sangmi Lee, Joo Hyeon Nam, Young Jun Cho, Joohoon Kim, Jae Yeol Lee, Ho-Jung Kang & Jungahn Kim

  2. Biomedical Science Center, KIST, Seoul, 136-791, Korea

    Sehoon Kim

  3. Department of Chemical Engineering, Sogang University, Seoul, 121-742, Korea

    Hoon Tae Kim & Heung Mok Park

Authors
  1. Jinheung Kim
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  2. Sangmi Lee
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  3. Joo Hyeon Nam
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  4. Young Jun Cho
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  5. Joohoon Kim
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  8. Sehoon Kim
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  9. Hoon Tae Kim
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  11. Jungahn Kim
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Correspondence to Jungahn Kim.

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Kim, J., Lee, S., Nam, J.H. et al. Synthesis of PEO-based block copolymers bearing cyclic hydrazide or carboxylic acid moieties and their applications as stabilizers for Fe3O4 nanoparticles. Macromol. Res. 19, 716–721 (2011). https://doi.org/10.1007/s13233-011-0716-0

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  • DOI: https://doi.org/10.1007/s13233-011-0716-0

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