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Recent Advance on Bioactive Compounds from the Edible and Medicinal Fungi in China

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Medicinal Plants and Fungi: Recent Advances in Research and Development

Part of the book series: Medicinal and Aromatic Plants of the World ((MAPW,volume 4))

Abstract

Natural products and their derivatives have played a prominent role in the history of drug discovery and remain the most attractive source of potential drugs because of their structural complexity and diversity. Edible and medicinal fungi have been shown to have profound health-promoting benefits and were recognized as an important source of natural products with diverse structures and distinct pharmacological potential. There are about 10,000 fungi species and 473 medicinal fungi species in China. The fruiting bodies of these mushrooms were used in Chinese traditional medicine to treat various diseases. Recently, chemical investigation of edible and medicinal fungi collected in China led to isolation and identification of a huge number of bioactive compounds with various bioactivities including antibacterial, antioxidant, anticancer, antiplasmodial, antiproliferative, antifibrotic, and neurite outgrowth-promoting activities. In this chapter, we review the studies on isolation, structural elucidation and biologically activities of bioactive compounds derived from edible and medicinal fungi conducted by Chinese scientists after 2007. Selected compounds with unique structural features and promising bioactivities have been described herein on the basis of structural types. The main types included are terpenes, meroterpenoids, polyketides, and alkaloids. A table that lists the name of fungi species, bioactive compounds, and medicinal properties is given along with 109 references.

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Abbreviations

Bax:

Bcl-2-like protein 4

Bcl-2:

B-cell lymphoma 2

BrdU:

5-Bromo-2-deoxyuridine

COX-2:

Cyclooxygenase-2

DPP-4:

Dipeptidyl peptidase-4

DPPH:

2,2-Diphenyl-1-picrylhydrazyl

GPP:

Geranyl pyrophosphate

HMGR:

3-Hydroxy-3-methylglutaryl-CoA reductase

IC50 :

Half maximal inhibitory concentration

iNOS:

Inducible nitric oxide synthase

LPS:

Lipopolysaccharide

MCP-1:

Monocyte chemotactic protein 1

MTT:

3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide

PTP1B:

Protein tyrosine phosphatase 1B

ROS:

Reactive oxygen species

TCM:

Traditional Chinese medicine

TGF-β1:

Transforming growth factor β1

References

  • Akihisa T, Nakamura Y, Tagata M, Tokuda H, Yasukawa K, Uchiyama E, Suzuki T, Kimura Y (2007) Anti-inflammatory and anti-tumor-promoting effects of triterpene acids. Chem Biodivers 4:224–231. doi:10.1002/cbdv.200790027

    Article  CAS  PubMed  Google Scholar 

  • Ao ZH, Xu ZH, Lu ZM, Xu HY, Zhang XM, Dou WF (2009) Niuchangchih (Antrodia camphorata) and its potential in treating liver diseases. J Ethnopharmacol 121(2):194–212. doi:10.1016/j.jep.2008.10.039

    Article  PubMed  Google Scholar 

  • Bai R, Zhang CC, Yin X, Wei J, Gao JM (2015) Striatoids A–F, cyathane diterpenoids with neurotrophic activity from cultures of the fungus Cyathus striatus. J Nat Prod 78(4):783–788. doi:10.1021/np501030r

    Article  CAS  PubMed  Google Scholar 

  • Cai HH, Liu XM, Chen ZY (2013) Isolation, purification and identification of nine chemical compounds from Flammulina velutipes fruiting bodies. Food Chem 141:2873–2879. doi:10.1016/j.foodchem.2013.05.124

    Article  CAS  PubMed  Google Scholar 

  • Cao WW, Luo Q, Cheng YX, Wang SM (2016) Meroterpenoid enantiomers from Ganoderma sinensis. Fitoterapia 110:110–115. doi:10.1016/j.fitote.2016.03.003

    Article  CAS  PubMed  Google Scholar 

  • Chang JC, Hsiao G, Lin RK, Kuo YH, Ju YM, Lee TH (2017) Bioactive constituents from the termite nest-derived medicinal fungus Xylaria nigripes. J Nat Prod 80(1):38–44. doi:10.1021/acs.jnatprod.6b00249

    Article  CAS  PubMed  Google Scholar 

  • Chen JJ, Lin WJ, Liao CH, Shieh PC (2007) Anti-inflammatory benzenoids from Antrodia camphorata. J Nat Prod 70(6):989–992. doi:10.1021/np070045e

    Article  CAS  PubMed  Google Scholar 

  • Chen M, Zhang M, Sun S, Xia B, Zhang HQ (2009) A new triterpene from the fruiting bodies of Ganoderma lucidum. Acta Pharm Sin 44:768–770

    CAS  Google Scholar 

  • Chen XL, Wu M, Ti HH, Wei XY, Li TH (2011) Three new 3,6-dioxygenated diketopiperazines from the Basidiomycete Lepista sordida. Helv Chim Acta 94:1426–1430. doi:10.1002/hlca.201000455

    Article  CAS  Google Scholar 

  • Chen HP, Zhao ZZ, Zhang Y, Bai X, Zhang L, Liu JK (2016) (+)-and (−)-ganodilactone, a pair of meroterpenoid dimers with pancreatic lipase inhibitory activities from the macromycete Ganoderma leucocontextum. RSC Adv 6(69):64469–64473. doi:10.1039/C6RA10638B

    Article  CAS  Google Scholar 

  • Cheng CR, Yue QX, Wu ZY, Song XY, Tao SJ, Wu XH, Xu PP, Liu X, Guan SH, Guo DA (2010) Cytotoxic triterpenoids from Ganoderma lucidum. Phytochemistry 71:1579–1585. doi:10.1016/j.phytochem.2010.06.005

    Article  CAS  PubMed  Google Scholar 

  • Chinese Pharmacopoeia Commission (2010) Pharmacopoeia of the People’s Republic of China, vol 1. China Medical Science and Technology Press, Beijing, pp 174–175

    Google Scholar 

  • Dai YC, Yang ZL (2008) A revised checklist of medicinal fungi in China. Mycosystema 27(6):801–824

    Google Scholar 

  • Dai YC, Zhou LW, Cui BK, Chen YQ, Decock C (2010) Current advances in Phellinus sensu lato: medicinal species, functions, metabolites and mechanisms. Appl Microbiol Biotechnol 87(5):1587–1593. doi:10.1007/s00253-010-2711-3

    Article  CAS  PubMed  Google Scholar 

  • Ding WY, Ai J, Wang XL, Qiu FG, Lv Q, Fang P, Hou FF, Yan YM, Cheng YX (2016) Isolation of lingzhifuran A and lingzhilactones D-F from Ganoderma lucidum as specific Smad3 phosphorylation inhibitors and total synthesis of lingzhifuran A. RSC Adv 6(81):77887–77897. doi:10.1039/C6RA17900B

    Article  CAS  Google Scholar 

  • Dou M, Di L, Zhou LL, Yan YM, Wang XL, Zhou FJ, Yang ZL, Li RT, Hou FF, Cheng YX (2014) Cochlearols A and B, polycyclic meroterpenoids from the fungus Ganoderma cochlear that have renoprotective activities. Org Lett 16(23):6064–6067. doi:10.1021/ol502806j

    Article  CAS  PubMed  Google Scholar 

  • Feng T, Li ZH, Dong ZJ, Su J, Li Y, Liu JK (2011) Non-isoprenoid botryane sesquiterpenoids from basidiomycete Boletus edulis and their cytotoxic activity. Nat Prod Biosprospect 1(1):29–32. doi:10.1007/s13659-011-0005-9

    Article  CAS  Google Scholar 

  • Gao YH, Zhou SF (2004) Chemopreventive and tumoricidal properties of Lingzhi mushroom Ganoderma lucidum (W.Curt.:Fr.) Lloyd (Aphyllophoromy cetideae). Part II. Mechanism considerations (review). Int J Med Mushr 6:219–230. doi:10.1615/IntJMedMushr.v6.i3.20

    Article  CAS  Google Scholar 

  • Geris R, Simpson TJ (2009) Meroterpenoids produced by fungi. Nat Prod Rep 26(8):1063–1094. doi:10.1039/B820413F

    Article  CAS  PubMed  Google Scholar 

  • Guan SH, Xia JM, Yang M, Wang XM, Liu X, Guo DA (2008) Cytotoxic lanostanoid triterpenes from Ganoderma lucidum. J Asian Nat Prod Res 10(8):695–700

    Article  CAS  Google Scholar 

  • Han J, Chen Y, Bao L, Yang X, Liu D, Li S, Zhao F, Liu H (2013) Anti-inflammatory and cytotoxic cyathane diterpenoids from the medicinal fungus Cyathus africanus. Fitoterapia 84:22–31. doi:10.1016/j.fitote.2012.10.001

    Article  CAS  PubMed  Google Scholar 

  • Han J, Zhang L, Xu JK, Bao L, Zhao F, Chen YH, Zhang WK, Liu H (2015) Three new cyathane diterpenoids from the medicinal fungus Cyathus africanus. J Asian Nat Prod Res 17(5):541–549. doi:10.1080/10286020.2015.1043900

    Article  CAS  PubMed  Google Scholar 

  • He CY, Li WD, Guo SX, Lin SQ, Lin ZB (2006) Effect of polysaccharides from Ganoderma lucidum on streptozotocin-induced diabetic nephropathy in mice. J Asian Nat Prod Res 8:705–711. doi:10.1080/10286020500289071

    Article  CAS  PubMed  Google Scholar 

  • He J, Tao J, Miao X, Bu W, Zhang S, Dong Z, Li Z, Feng T, Liu J (2015a) Seven new drimane-type sesquiterpenoids from cultures of fungus Laetiporus sulphureus. Fitoterapia 102:1–6. doi:10.1016/j.fitote.2015.01.022

    Article  PubMed  CAS  Google Scholar 

  • He J, Tao J, Miao X, Feng Y, Bu W, Dong Z, Li Z, Feng T, Liu J (2015b) Two new illudin type sesquiterpenoids from cultures of Phellinus tuberculosus and Laetiporus sulphureus. J Asian Nat Prod Res 17(11):1054–1058. doi:10.1080/10286020.2015.1040774

    Article  CAS  PubMed  Google Scholar 

  • He L, Han J, Li B, Huang L, Ma K, Chen Q, Liu X, Bao L, Liu H (2016) Identification of a new cyathane diterpene that induces mitochondrial and autophagy-dependent apoptosis and shows a potent in vivo anti-colorectal cancer activity. Eur J Med Chem 111:183–192. doi:10.1016/j.ejmech.2016.01.056

    Article  CAS  PubMed  Google Scholar 

  • Huang M, Chen X, Tian H, Sun B, Chen H (2011) Isolation and identification of antibiotic albaflavenone from Dictyophora indusiata (Vent: Pers.) Fischer. J Chem Res 35(11):659–660. doi:10.3184/174751911X13202334527264

    Article  CAS  Google Scholar 

  • Huang L, Han J, Ben-Hail D, He L, Li B, Chen Z, Wang Y, Yang Y, Liu L, Zhu Y, Shoshan-Barmatz V, Liu H, Chen Q (2015) A new fungal diterpene induces VDAC1-dependent apoptosis in Bax/Bak-deficient cells. J Biol Chem 290:23563–23578. doi:10.1074/jbc.M115.648774

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kawagishi H, Shimada A, Shirai R, Okamoto K, Ojima F, Sakamoto H, Ishiguro Y, Furukawa S (1994) Erinacines A, B and C, strong stimulators of nerve growth factor synthesis, from the mycelia of Hericium erinaceus. Tetrahedron Lett 35:1569–1572. doi:10.1016/S0040-4039(00)76760-8

    Article  CAS  Google Scholar 

  • Kawagishi H, Shimada A, Hosokawa S, Mori H, Sakamoto H, Ishiguro Y, Sakemi S, Bordner J, Kojima N, Furukawa S (1996a) Erinacines E, F, and G, stimulators of nerve growth factor (NGF)-synthesis, from the mycelia of Hericium erinaceum. Tetrahedron Lett 37:7399–7402. doi:10.1016/0040-4039(96)01687-5

    Article  CAS  Google Scholar 

  • Kawagishi H, Simada A, Shizuki K, Ojima F, Mori H, Okamoto K, Sakamoto H, Furukawa S (1996b) Erinacine D, a stimulator of NGF-synthesis, from the mycelia of Hericium erinaceum. Heterocycl Commun 2(1):51–54. doi:10.1515/HC.1996.2.1.51

    Article  CAS  Google Scholar 

  • Kawagishi H, Masui A, Tokuyamab S, Nakamurac T (2006) Erinacines J and K from the mycelia of Hericium erinaceum. Tetrahedron 62(36):8463–8466. doi:10.1016/j.tet.2006.06.091

    Article  CAS  Google Scholar 

  • Ko HJ, Song A, Lai MN, Ng LT (2011) Immunomodulatory properties of Xylaria nigripes in peritoneal macrophage cells of Balb/c mice. J Ethnopharmacol 138(3):762–768. doi:10.1016/j.jep.2011.10.022

    Article  PubMed  Google Scholar 

  • Lee EW, Shizuki K, Hosokawa S, Suzuki M, Suganuma H, Inakuma T, Kawagishi H (2000) Two novel diterpenoids, erinacines H and I from the mycelia of Hericium erinaceum. Biosci Biotechnol Biochem 64(11):2402–2405. doi:10.1271/bbb.64.2402

    Article  CAS  PubMed  Google Scholar 

  • Li YQ, Wang SF (2006) Anti-hepatitis B activities of ganoderic acid from Ganoderma lucidum. Biotechnol Lett 28:837–841. doi:10.1007/s10529-006-9007-9

    Article  CAS  PubMed  Google Scholar 

  • Li Y, Bao L, Song B, Han J, Li H, Zhao F, Liu H (2013a) A new benzoquinone and a new benzofuran from the edible mushroom Neolentinus lepideus and their inhibitory activity in NO production inhibition assay. Food Chem 141(3):1614–1618. doi:10.1016/j.foodchem.2013.04.133

    Article  CAS  PubMed  Google Scholar 

  • Li P, Deng YP, Wei XX, Xu JH (2013b) Triterpenoids from Ganoderma lucidum and their cytotoxic activities. Nat Prod Res 27(1):17–22. doi:10.1080/14786419.2011.652961

    Article  PubMed  CAS  Google Scholar 

  • Li YX, Han JJ, Yang XL, Li HR, Wang YQ, Wang SJ, Bao L (2013c) Bioactive composition of the solid culture of the edible mushroom Pleurotus citrinopileatus on rice and the antioxidant effect evaluation. Mycosystema 32(5):876–882

    CAS  Google Scholar 

  • Li L, Li H, Peng XR, Hou B, Yu MY, Dong JR, Li XN, Zhou L, Yang J, Qiu MH (2016a) (±)-Ganoapplanin, a pair of polycyclic meroterpenoid enantiomers from Ganoderma applanatum. Org Lett 18(23):6078–6081. doi:10.1021/acs.orglett.6b03064

    Article  CAS  PubMed  Google Scholar 

  • Li Z, Wang Y, Jiang B, Li W, Zheng L, Yang X, Bao YL, Sun LG, Huang YX, Li Y (2016b) Structure, cytotoxic activity and mechanism of protoilludane sesquiterpene aryl esters from the mycelium of Armillaria mellea. J Ethnopharmacol 184:119–127. doi:10.1016/j.jep.2016.02.044

    Article  CAS  PubMed  Google Scholar 

  • Liang WL, Hsiao CJ, Ju YM, Lee LH, Lee TH (2011) Chemical constituents of the fermented broth of the ascomycete Theissenia cinerea 89091602. Chem Biodivers 8(12):2285–2290. doi:10.1002/cbdv.201000329

    Article  CAS  PubMed  Google Scholar 

  • Lin ZB (2001) Pharmacological functions of Ganoderma lucidum. In: Lin Z-B (ed) Modern research of Ganoderma lucidum. Beijing Medical University Press, Beijing

    Google Scholar 

  • Lin ZB, Zhang HN (2004) Anti-tumor and immunoregulatory activities of Ganoderma lucidum and its possible mechanisms. Acta Pharmacol Sin 25:1387–1395

    CAS  PubMed  Google Scholar 

  • Liu C, Zhao F, Chen R (2010) A novel alkaloid from the fruiting bodies of Ganoderma sinense Zhao, Xu et Zhang. Chin Chem Lett 21:197–199. doi:10.1016/j.cclet.2009.07.023

    Article  CAS  Google Scholar 

  • Liu JQ, Wang CF, Peng XR, Qiu MH (2011) New alkaloids from the fruiting bodies of Ganoderma sinense. Nat Prod Bioprospect 1:93–96. doi:10.1007/s13659-011-0026-4

    Article  CAS  PubMed Central  Google Scholar 

  • Liu JQ, Wang CF, Li Y, Luo HR, Qiu MH (2012) Isolation and bioactivity evaluation of terpenoids from the medicinal fungus Ganoderma sinense. Planta Med 78:368–376. doi:10.1055/s-0031-1280441

    Article  CAS  PubMed  Google Scholar 

  • Liu S, Dong Y, Li Y, Bao L, Liu H, Li H (2013) Chemical constituents from the rice fermented with the edible mushroom Pleurotus eryngii and their quinone oxidoreductase 1 inducing effect. Fitoterapia 91:9–14. doi:10.1016/j.fitote.2013.07.022

    Article  CAS  PubMed  Google Scholar 

  • Luo Q, Di L, Dai WF, Lu Q, Yan YM, Yang ZL, Li RT, Cheng YX (2015a) Applanatumin A, a new dimeric meroterpenoid from Ganoderma applanatum that displays potent antifibrotic activity. Org Lett 17(5):1110–1113. doi:10.1021/ol503610b

    Article  CAS  PubMed  Google Scholar 

  • Luo Q, Tian L, Di L, Yan YM, Wei XY, Wang XF, Cheng YX (2015b) (±)-Sinensilactam A, a pair of rare hybrid metabolites with Smad3 phosphorylation inhibition from Ganoderma sinensis. Org Lett 17(6):1565–1568. doi:10.1021/acs.orglett.5b00448

    Article  CAS  PubMed  Google Scholar 

  • Luo Q, Wang XL, Di L, Yan YM, Lu Q, Yang XH, Hu DB, Cheng YX (2015c) Isolation and identification of renoprotective substances from the mushroom Ganoderma lucidum. Tetrahedron 71(5):840–845. doi:10.1016/j.tet.2014.12.052

    Article  CAS  Google Scholar 

  • Luo Q, Di L, Yang XH, Cheng YX (2016a) Applanatumols A and B, meroterpenoids with unprecedented skeletons from Ganoderma applanatum. RSC Adv 6(51):45963–45967. doi:10.1039/C6RA05148K

    Article  CAS  Google Scholar 

  • Luo Q, Yang XH, Yang ZL, Tu ZC, Cheng YX (2016b) Miscellaneous meroterpenoids from Ganoderma applanatum. Tetrahedron 72(30):4564–4574. doi:10.1016/j.tet.2016.06.019

    Article  CAS  Google Scholar 

  • Luo Q, Wei XY, Yang J, Luo JF, Liang R, Tu ZC, Cheng YX (2017) Spiro meroterpenoids from Ganoderma applanatum. J Nat Prod 80(1):61–70. doi:10.1021/acs.jnatprod.6b00431

    Article  CAS  PubMed  Google Scholar 

  • Ma BJ, Ma JC, Ruan Y (2012) Hericenone L, a new aromatic compound from the fruiting bodies of Hericium erinaceum. Chin J Nat Med 10:363–365. doi:10.1016/S1875-5364(12)60072-7

    CAS  Google Scholar 

  • Ma K, Ren J, Han J, Bao L, Li L, Yao Y, Sun C, Zhou B, Liu H (2014) Ganoboninketals A-C, antiplasmodial 3,4-seco-27-norlanostane triterpenes from Ganoderma boninense Pat. J Nat Prod 77:1847–1852. doi:10.1021/np5002863

    Article  CAS  PubMed  Google Scholar 

  • Ma K, Li L, Bao L, He L, Sun C, Zhou B, Si S, Liu H (2015) Six new 3, 4-seco-27-norlanostane triterpenes from the medicinal mushroom Ganoderma boninense and their antiplasmodial activity and agonistic activity to LXR. Tetrahedron 71(12):1808–1814. doi:10.1016/j.tet.2015.02.002

    Article  CAS  Google Scholar 

  • Mizuno T (1999) Bioactive substances in Hericium erinaceus (Bull., Fr.) Pers. (Yambushitake) and its medicinal utilization. Int J Med Mushr 2:105–119. doi:10.1615/IntJMedMushrooms.v1.i2.10

    Article  Google Scholar 

  • Nonaka Y, Shibata H, Nakai M (2006) Anti-tumor activities of the antlered form of Ganoderma lucidum in allogeneic and syngeneic tumor-bearing mice. Biosci Biotechnol Biochem 70:2028–2034. doi:10.1271/bbb.50509

    Article  CAS  PubMed  Google Scholar 

  • Norikura T, Fujiwara K, Yanai T, Sano Y, Sato T, Tsunoda T, Kushibe K, Todate A, Morinaga Y, Iwai K, Matsue H (2013) p-terphenyl derivatives from the mushroom Thelephora aurantiotincta suppress the proliferation of human hepatocellular carcinoma cells via iron chelation. J Agric Food Chem 61:1258–1264. doi:10.1021/jf3041098

    Article  CAS  PubMed  Google Scholar 

  • Peng XR, Liu JQ, Xia JJ, Yang YH, Qiu MH (2012) Two new triterpenoids from Ganoderma cochlear. Chin Tradit Herb Drug 43(6):1045–1049

    CAS  Google Scholar 

  • Peng XR, Liu JQ, Wan LS, Li XN, Yan YX, Qiu MH (2014a) Four new polycyclic meroterpenoids from Ganoderma cochlear. Org Lett 16(20):5262–5265. doi:10.1021/ol5023189

    Article  PubMed  CAS  Google Scholar 

  • Peng XR, Liu JQ, Wang CF, Li XY, Shu Y, Zhou L, Qiu MH (2014b) Hepatoprotective effects of triterpenoids from Ganoderma cochlear. J Nat Prod 77:737–743. doi:10.1021/np400323u

    Article  CAS  PubMed  Google Scholar 

  • Peng X, Liu J, Wang C, Han Z, Shu Y, Li X, Zhou L, Qiu M (2015a) Unusual prenylated phenols with antioxidant activities from Ganoderma cochlear. Food Chem 171:251–257. doi:10.1016/j.foodchem.2014.08.127

    Article  CAS  PubMed  Google Scholar 

  • Peng XR, Wang X, Zhou L, Hou B, Zuo ZL, Qiu MH (2015b) Ganocochlearic acid A, a rearranged hexanorlanostane triterpenoid, and cytotoxic triterpenoids from the fruiting bodies of Ganoderma cochlear. RSC Adv 5(115):95212–95222. doi:10.1039/C5RA16796E

    Article  CAS  Google Scholar 

  • Peng X, Li L, Wang X, Zhu G, Li Z, Qiu M (2016) Antioxidant farnesylated hydroquinones from Ganoderma capense. Fitoterapia 111:18–23. doi:10.1016/j.fitote.2016.04.006

    Article  CAS  PubMed  Google Scholar 

  • Qiao Y, Zhang XM, Qiu MH (2007) Two novel lanostane triterpenoids from Ganoderma sinense. Molecules 12(8):2038–2046. doi:10.3390/12082038

    Article  CAS  PubMed  Google Scholar 

  • Shen JW, Ruan Y, Ma BJ (2009) Diterpenoids of macromycetes. J Basic Microbiol 49(3):242–255. doi:10.1002/jobm.200800102

    Article  CAS  PubMed  Google Scholar 

  • Tao Q, Ma K, Yang Y, Wang K, Chen B, Huang Y, Han J, Bao L, Liu XB, Yang Z, Yin WB, Liu H (2016a) Bioactive sesquiterpenes from the edible mushroom Flammulina velutipes and their biosynthetic pathway confirmed by genome analysis and chemical evidence. J Org Chem 81(20):9867–9877. doi:10.1021/acs.joc.6b01971

    Article  CAS  PubMed  Google Scholar 

  • Tao Q, Ma K, Bao L, Wang K, Han J, Wang W, Zhang J, Huang C, Liu H (2016b) Sesquiterpenoids with PTP1B inhibitory activity and cytotoxicity from the edible mushroom Pleurotus citrinopileatus. Planta Med 82(07):639–644. doi:10.1055/s-0041-111629

    Article  CAS  PubMed  Google Scholar 

  • Tao Q, Ma K, Bao L, Wang K, Han J, Zhang J, Huang C, Liu H (2016c) New sesquiterpenoids from the edible mushroom Pleurotus cystidiosus and their inhibitory activity against α-glucosidase and PTP1B. Fitoterapia 111:29–35. doi:10.1016/j.fitote.2016.04.007

    Article  CAS  PubMed  Google Scholar 

  • Tu SH, Wu CH, Chen LC, Huang CS, Chang HW, Chang CH, Lien HM, Ho YS (2012) In vivo antitumor effects of 4,7-dimethoxy-5-methyl-1,3-benzodioxole isolated from the fruiting body of Antrodia camphorata through activation of the p53-mediated p27/Kip1 signaling pathway. J Agric Food Chem 60:3612–3618. doi:10.1021/jf300221g

    Article  CAS  PubMed  Google Scholar 

  • Wang CF, Liu JQ, Yan YX, Chen JC, Yang L, Gao YH, Qiu MH (2010) Three new triterpenoids containing four-membered ring from the fruiting body of Ganoderma sinense. Org Lett 12(8):1656–1659. doi:10.1021/ol100062b

    Article  CAS  PubMed  Google Scholar 

  • Wang Y, Bao L, Liu D, Yang X, Li S, Gao H, Yao X, Wen H, Liu H (2012a) Two new sesquiterpenes and six norsesquiterpenes from the solid culture of the edible mushroom Flammulina velutipes. Tetrahedron 68:3012–3018. doi:10.1016/j.tet.2012.02.021

    Article  CAS  Google Scholar 

  • Wang Y, Bao L, Yang X, Dai H, Guo H, Yao X, Liu H (2012b) Four new cuparene-type sesquiterpenes from Flammulina velutipes. Helv Chim Acta 95(2):261–267. doi:10.1002/hlca.201100289

    Article  CAS  Google Scholar 

  • Wang Y, Bao L, Yang X, Li L, Li S, Gao H, Yao X, Wen H, Liu H (2012c) Bioactive sesquiterpenoids from the solid culture of the edible mushroom Flammulina velutipes growing on cooked rice. Food Chem 132:1346–1353. doi:10.1016/j.foodchem.2011.11.117

    Article  CAS  Google Scholar 

  • Wang SJ, Li YX, Bao L, Han JJ, Yang XL, Li HR, Wang YQ, Li SJ, Liu HW (2012d) Eryngiolide A, a cytotoxic macrocyclic diterpenoid with an unusual cyclododecane core skeleton produced by the edible mushroom Pleurotus eryngii. Org Lett 14(14):3672–3675. doi:10.1021/ol301519m

    Article  CAS  PubMed  Google Scholar 

  • Wang S, Bao L, Han J, Wang Q, Yang X, Wen H, Guo L, Li S, Zhao F, Liu H (2013a) Pleurospiroketals A-E, Perhydrobenzannulated 5, 5-spiroketal sesquiterpenes from the edible mushroom Pleurotus cornucopiae. J Nat Prod 76(1):45–50. doi:10.1021/np3006524

    Article  CAS  PubMed  Google Scholar 

  • Wang S, Bao L, Zhao F, Wang Q, Li S, Ren J, Li L, Wen H, Guo L, Liu H (2013b) Isolation, identification, and bioactivity of monoterpenoids and sesquiterpenoids from the mycelia of edible mushroom Pleurotus cornucopiae. J Agric Food Chem 61:5122–5129. doi:10.1021/jf401612t

    Article  CAS  PubMed  Google Scholar 

  • Wang B, Han J, Xu W, Chen Y, Liu H (2014a) Production of bioactive cyathane diterpenes by a bird’s nest fungus Cyathus gansuensis growing on cooked rice. Food Chem 152:169–176. doi:10.1016/j.foodchem.2013.11.137

    Article  CAS  PubMed  Google Scholar 

  • Wang SC, Lee TH, Hsu CH, Chang YJ, Chang MS, Wang YC, Ho YS, Wen WC, Lin RK (2014b) Antroquinonol D, isolated from Antrodia camphorate, with DNA demethylation and anticancer potential. J Agric Food Chem 62:5625–5635. doi:10.1021/jf4056924

    Article  CAS  PubMed  Google Scholar 

  • Wang K, Bao L, Ma K, Liu N, Huang Y, Ren J, Wang W, Liu H (2015a) Eight new alkaloids with PTP1B and α-glucosidase inhibitory activities from the medicinal mushroom Hericium erinaceus. Tetrahedron 71(51):9557–9563. doi:10.1016/j.tet.2015.10.068

    Article  CAS  Google Scholar 

  • Wang K, Bao L, Qi Q, Zhao F, Ma K, Pei Y, Liu H (2015b) Erinacerins C-L, isoindolin-1-ones with α-glucosidase inhibitory activity from cultures of the medicinal mushroom Hericium erinaceus. J Nat Prod 78(1):146–154. doi:10.1021/np5004388

    Article  CAS  PubMed  Google Scholar 

  • Wang K, Bao L, Xiong W, Ma K, Han J, Wang W, Yin W, Liu H (2015c) Lanostane triterpenes from the Tibetan medicinal mushroom Ganoderma leucocontextum and their inhibitory effects on HMG-CoA reductase and α-glucosidase. J Nat Prod 78:1977–1989. doi:10.1021/acs.jnatprod.5b00331

    Article  CAS  PubMed  Google Scholar 

  • Wang J, Sun W, Luo H, He H, Deng W, Zou K, Liu C, Song J, Huang W (2015d) Protective effect of eburicoic acid of the chicken of the woods mushroom, Laetiporus sulphureus (higher basidiomycetes), against gastric ulcers in mice. Int J Med Mushr 17:619–626. doi:10.1615/IntJMedMushrooms.v17.i7.20

    Article  Google Scholar 

  • Wang K, Bao L, Ma K, Zhang J, Chen B, Han J, Ren J, Luo H, Liu H (2016a) A novel class of α-glucosidase and HMG-CoA reductase inhibitors from Ganoderma leucocontextum and the anti-diabetic properties of ganomycin I in KK-Ay mice. Eur J Med Chem 127:1035–1046. doi:10.1016/j.ejmech.2016.11.015

    Article  PubMed  CAS  Google Scholar 

  • Wang XL, Gao J, Li J, Long HP, Xu PS, Xu KP, Tan GS (2016b) Three new isobenzofuranone derivatives from the fruiting bodies of Hericium erinaceus. J Asian Nat Prod Res 19(2):134–139. doi:10.1080/10286020.2016.1183653

    Article  PubMed  CAS  Google Scholar 

  • Wang XL, Xu KP, Long HP, Zou H, Cao XZ, Zhang K, Hu JZ, He SJ, Zhu GZ, He XA, Xu PS, Tan GS (2016c) New isoindolinones from the fruiting bodies of Hericium erinaceum. Fitoterapia 111:58–65. doi:10.1016/j.fitote.2016.04.010

    Article  CAS  PubMed  Google Scholar 

  • Wang XL, Zhou FJ, Dou M, Yan YM, Wang SM, Di L, Cheng YX (2016d) Cochlearoids F-K: phenolic meroterpenoids from the fungus Ganoderma cochlear and their renoprotective activity. Bioorg Med Chem Lett 26(22):5507–5512. doi:10.1016/j.bmcl.2016.10.011

    Article  CAS  PubMed  Google Scholar 

  • Xu Z, Yan S, Bi K, Han J, Chen Y, Wu Z, Liu H (2013) Isolation and identification of a new anti-inflammatory cyathane diterpenoid from the medicinal fungus Cyathus hookeri Berk. Fitoterapia 86:159–162. doi:10.1016/j.fitote.2013.03.002

    Article  CAS  PubMed  Google Scholar 

  • Xue Z, Li J, Cheng A, Yu W, Zhang Z, Kou X, Zhou F (2015) Structure identification of triterpene from the mushroom Pleurotus eryngii with inhibitory effects against breast cancer. Plant Foods Hum Nutr 70:291–296. doi:10.1007/s11130-015-0492-7

    Article  CAS  PubMed  Google Scholar 

  • Yan YM, Ai J, Zhou LL, Chung AC, Li R, Nie J, Fang P, Wang XL, Luo J, Hu Q, Hou FF, Cheng YX (2013) Lingzhiols, unprecedented rotary door-shaped meroterpenoids as potent and selective inhibitors of p-Smad3 from Ganoderma lucidum. Org Lett 15(21):5488–5491. doi:10.1021/ol4026364

    Article  CAS  PubMed  Google Scholar 

  • Yan YM, Wang XL, Luo Q, Jiang LP, Yang CP, Hou B, Zuo ZL, Chen YB, Cheng YX (2015a) Metabolites from the mushroom Ganoderma lingzhi as stimulators of neural stem cell proliferation. Phytochemistry 114:155–162. doi:10.1016/j.phytochem.2015.03.013

    Article  CAS  PubMed  Google Scholar 

  • Yan YM, Wang XL, Zhou LL, Zhou FJ, Li R, Tian Y, Zuo ZL, Fang P, Chung AC, Hou FF, Cheng YX (2015b) Lingzhilactones from Ganoderma lingzhi ameliorate adriamycin-induced nephropathy in mice. J Ethnopharmacol 176:385–393. doi: J Ethnopharmacol 176:385–393

    Article  CAS  PubMed  Google Scholar 

  • Yang SS, Wang GJ, Wang SY, Lin YY, Kuo YH, Lee TH (2009) New constituents with iNOS inhibitory activity from mycelium of Antrodia camphorata. Planta Med 75(05):512–516. doi:10.1055/s-0029-1185305

    Article  CAS  PubMed  Google Scholar 

  • Yang TK, Lee YH, Paudel U, Bhattarai G, Yun BS, Hwang PH, Yi HK (2013a) Davallialactone from mushroom reduced premature senescence and inflammation on glucose oxidative stress in human diploid fibroblast cells. J Agric Food Chem 61(29):7089–7095. doi:10.1021/jf401691y

    Article  CAS  PubMed  Google Scholar 

  • Yang J, Wang N, Yuan HS, Hu JC, Dai YC (2013b) A new sesquiterpene from the medicinal fungus Inonotus vaninii. Chem Nat Compd 49(2):261–263. doi:10.1007/s10600-013-0576-2

    Article  CAS  Google Scholar 

  • Yen IC, Yao CW, Kuo MT, Chao CL, Pai CY, Chang WL (2015) Anti-cancer agents derived from solid-state fermented Antrodia camphorata mycelium. Fitoterapia 102:115–119. doi:10.1016/j.fitote.2015.02.010

    Article  CAS  PubMed  Google Scholar 

  • Yin X, Li ZH, Li Y, Feng T, Liu JK (2015) Four lanostane-type triterpenes from the fruiting bodies of mushroom Laetiporus sulphureus var. miniatus. J Asian Nat Prod Res 17(8):793–799. doi:10.1080/10286020.2015.1027694

    Article  CAS  PubMed  Google Scholar 

  • Zhang XQ, Ip FC, Zhang DM, Chen LX, Zhang W, Li YL, Ip NY, Ye WC (2011) Triterpenoids with neurotrophic activity from Ganoderma lucidum. Nat Prod Rep 25(17):1607–1613. doi:10.1080/14786419.2010.496367

    Article  CAS  Google Scholar 

  • Zhang Z, Liu RN, Tang QJ, Zhang JS, Yang Y, Shang XD (2015a) A new diterpene from the fungal mycelia of Hericium erinaceus. Phytochem Lett 11:151–156. doi:10.1016/j.phytol.2014.12.011

    Article  CAS  Google Scholar 

  • Zhang CC, Yin X, Cao CY, Wei J, Zhang Q, Gao JM (2015b) Chemical constituents from Hericium erinaceus and their ability to stimulate NGF-mediated neurite outgrowth in PC12 cells. Bioorg Med Chem Lett 25(22):5078–5082. doi:10.1016/j.bmcl.2015.10.016

    Article  CAS  PubMed  Google Scholar 

  • Zhao Z, Li Y, Chen H, Huang L, Zhao F, Yu Q et al (2014) Xylaria nigripes mitigates spatial memory impairment induced by rapid eye movement sleep deprivation. Int J Clin Exp Med 7(2):356–362

    PubMed  PubMed Central  Google Scholar 

  • Zhao ZZ, Chen HP, Feng T, Li ZH, Dong ZJ, Liu JK (2015) Lucidimine AD, four new alkaloids from the fruiting bodies of Ganoderma lucidum. J Asian Nat Prod Res 17(12):1160–1165. doi:10.1080/10286020.2015.1119128

    Article  CAS  PubMed  Google Scholar 

  • Zhao ZZ, Chen HP, Huang Y, Li ZH, Zhang L, Feng T, Liu JK (2016a) Lanostane triterpenoids from fruiting bodies of Ganoderma leucocontextum. Nat Prod Biosprospect 6(2):103–109. doi:10.1007/s13659-016-0089-3

    Article  CAS  Google Scholar 

  • Zhao ZZ, Chen HP, Li ZH, Dong ZJ, Bai X, Zhou ZY, Feng T, Liu JK (2016b) Leucocontextins A-R, lanostane-type triterpenoids from Ganoderma leucocontextum. Fitoterapia 109:91–98. doi:10.1016/j.fitote.2015.12.004

    Article  CAS  PubMed  Google Scholar 

  • Zheng Y, Pang H, Wang J, Shi G, Huang J (2015) New apoptosis-inducing sesquiterpenoids from the mycelial culture of Chinese edible fungus Pleurotus cystidiosus. J Agric Food Chem 63(2):545–551. doi:10.1021/jf504931n

    Article  CAS  PubMed  Google Scholar 

  • Zhou FJ, Nian Y, Yan Y, Gong Y, Luo Q, Zhang Y, Hou B, Zuo ZL, Wang SM, Jiang HH, Yang J, Cheng YX (2015) Two new classes of T-type calcium channel inhibitors with new chemical scaffolds from Ganoderma cochlear. Org Lett 17(12):3082–3085. doi:10.1021/acs.orglett.5b01353

    Article  CAS  PubMed  Google Scholar 

  • Zhu XL, Chen AF, Lin ZB (2007) Ganoderma lucidum polysaccharides enhance the function of immunological effector cells in immunosuppressed mice. J Ethnopharmacol 111(2):219–226. doi:10.1016/j.jep.2006.11.013

    Article  CAS  PubMed  Google Scholar 

  • Zjawiony JK (2004) Biologically active compounds from Aphyllophorales (polypore) fungi. J Nat Prod 67(2):300–310. doi:10.1021/np030372w

    Article  CAS  PubMed  Google Scholar 

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Acknowledgments

The authors would like to acknowledge support from the National Natural Science Foundation of China (21602247 and 21472233) and the Ministry of Science and Technology of China (2014CB138304).

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Authors and Affiliations

  1. State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China

    Yan-Long Yang, Qiao-Qiao Tao, Jun-Jie Han, Li Bao & Hong-Wei Liu

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  1. Yan-Long Yang
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  2. Qiao-Qiao Tao
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  3. Jun-Jie Han
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  4. Li Bao
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  5. Hong-Wei Liu
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Correspondence to Hong-Wei Liu .

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Editors and Affiliations

  1. Department of Applied Chemistry, Chaoyang University of Technology, Taichung, Taiwan

    Dinesh Chandra Agrawal

  2. Department of Applied Chemistry, Chaoyang University of Technology, Taichung, Taiwan

    Hsin-Sheng Tsay

  3. Agricultural Biotechnology Research Center, Academia Sinica, Taipei, Taiwan

    Lie-Fen Shyur

  4. Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, Taiwan

    Yang-Chang Wu

  5. Department of Forestry, National Chung Hsing University, Taichung, Taiwan

    Sheng-Yang Wang

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Yang, YL., Tao, QQ., Han, JJ., Bao, L., Liu, HW. (2017). Recent Advance on Bioactive Compounds from the Edible and Medicinal Fungi in China. In: Agrawal, D., Tsay, HS., Shyur, LF., Wu, YC., Wang, SY. (eds) Medicinal Plants and Fungi: Recent Advances in Research and Development. Medicinal and Aromatic Plants of the World, vol 4. Springer, Singapore. https://doi.org/10.1007/978-981-10-5978-0_9

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