Abstract
Even though cell–cell adhesion molecule carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is extensively studied since the discovery, the role of CEACAM1 in different cancers is not completely clarified. In the present study, we examined CEACAM1 expression and its association with patient survival in various cancers by analysis of multiple databases. Oncomine database analysis revealed that CEACAM1 expression was upregulated in lung and pancreatic cancers, but downregulated in colorectal and head and neck cancers. PrognoScan and Kaplan‑Meier analyses showed that colorectal cancer patients as well as head and neck cancer patients with high CEACAM1 expression exhibited a higher overall survival rate. STRING analysis identified CEACAM3, CEACAM8, FN1, etc. as CEACAM1 interactors. Gene alteration analysis showed that CEACAM1 mutation predominantly occurred in the N-terminal. Coexpression analysis demonstrated that CEACAM1 had distinct coexpressed genes in different cancers, but KRT protein was consistently coexpressed with CEACAM1 in diverse cancer types. All the observations supported that CEACAM1 can serve as a diagnostic marker for some cancers, such as pancreatic cancer. And high CEACAM1 expression provides a better prognosis for some cancers, such as colorectal and head and neck cancers.
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Acknowledgements
We acknowledge the data contributors of the TCGA, Oncomine, Kaplan–Meier plotter, Prognoscan, STRING and cBioPortal databases. The enormous data in these databases are the foundation of deep exploration, multidimensional analysis and delicate visualization across multiple cancers. Additionally, we acknowledge Natural Science Foundation of Zhejiang Province (No. LQ18C010005) for supporting this work.
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CW and YW designed the study, statistically analyzed the data and drafted the manuscript, CW and XH collected the data, YW revised the manuscript. All authors read and approved the final manuscript.
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Weng, CY., Hu, XY. & Wang, YJ. Integrated analysis of gene expression, alteration and clinical significance of carcinoembryonic antigen-related cell adhesion molecule 1 in cancer. 3 Biotech 10, 132 (2020). https://doi.org/10.1007/s13205-020-2122-9
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DOI: https://doi.org/10.1007/s13205-020-2122-9