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Neurotoxicity of ZnO nanoparticles and associated motor function deficits in mice

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Abstract

Nano-sized zinc is extensively used by various industries and exposure of humans to these nanoparticles is increasing by the day. Mounting evidence suggests that health hazards are induced by metallic nanoparticles. However, at present, there is insufficient information concerning the impairment of motor functions due to exposure to metallic nanoparticles, particularly zinc oxide (ZnO) nanoparticles. The present study evaluates the toxic effects of ZnO nanoparticles in Swiss albino mice. Motor functions impairments were monitored using beam balance, and pole and footprint tests. Results showed that ZnO nanoparticles cause deficits in normal motor functions. Histopathological investigations revealed significantly (p < 0.01) increased motor cortex nuclear size probably resulting from neuroinflammation/neuronal damage. Overall, it is concluded that ZnO nanoparticles induce neurotoxicity resulting in motor function impairments.

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Acknowledgements

The authors are highly thankful to the Department of Physics and CASP (Centre of Advanced Physics) Government College University, Lahore, Pakistan, for providing the facilities for characterization of nanoparticles. Provision of laboratory facilities, model animals, and personnel support by the Department of Zoology, Government College University, Lahore, Pakistan, is dually acknowledged.

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Authors and Affiliations

  1. Department of Zoology, Government College University, Lahore, Pakistan

    Atif Yaqub, Ijaz Faheem, Sarwar Allah Ditta, Fouzia Tanvir & Chand Raza

  2. Department of Wildlife and Ecology, University of Veterinary and Animal Sciences, Lahore, Pakistan

    Khalid Mahmood Anjum

  3. Department of Biological Sciences, F.C. College University, Lahore, Pakistan

    Muhammad Zubair Yousaf

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  1. Atif Yaqub
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  2. Ijaz Faheem
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Correspondence to Atif Yaqub.

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Yaqub, A., Faheem, I., Anjum, K.M. et al. Neurotoxicity of ZnO nanoparticles and associated motor function deficits in mice. Appl Nanosci 10, 177–185 (2020). https://doi.org/10.1007/s13204-019-01093-3

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