Abstract
Because of good optical and electrical properties, TiO2 nanoparticles are widely used in many fields of industry and medicine. To assess the effect of TiO2 nanoparticles on mice cognitive abilities and their accumulation in different organs, daily, up to 2-month period, experimental mice were administrated with TiO2 nanoparticles solution. Accumulation of titanium in blood, brain, liver, kidney, lungs and feces was assessed by neutron activation analysis. Cognitive abilities in mice before and after TiO2 nanoparticles administration were evaluated in the Morris water maze behavioral test. The amount of titanium in all organs was below the limits of detection of the method and in feces it constituted 74 ± 7 µg/g. In the main Morris water maze behavioral test at the control points statistically significant differences were found in the parameters of treks between capable experimental and control animals.
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REFERENCES
S. Chavan, V. Sarangdhar, and V. Nadanathangam, “Toxicological effects of TiO2 nanoparticles on plant growth promoting soil bacteria,” Emerg. Contam. 6, 87–92 (2020).
N. Miura, K. Ohtani, T. Hasegawa, H. Yoshioka, and G. W. Hwang, “Biphasic adverse effect of titanium nanoparticles on testicular function in mice,” Sci. Rep. 9 (2019). https://doi.org/10.1038/s41598-019-50741-9
E. Baranowska-Wójcik, D. Szwajgier, P. Oleszczuk, and A. Winiarska-Mieczan, “Effects of titanium dioxide nanoparticles exposure on human health, a review,” Biol. Trace Elem. Res. 193, 118–129 (2020).
H. Shi, R. Magaye, V. Castranova, and J. Zhao, “Titanium dioxide nanoparticles: A review of current toxicological data,” Part. Fibre Toxicol. 10 (2013). https://doi.org/10.1186/1743-8977-10-15
X. Jia, S. Wang, L. Zhou, and L. Sun, “The potential liver, brain, and embryo toxicity of titanium dioxide nanoparticles on mice,” Nanoscale Res. Lett. 12 (2017). https://doi.org/10.1186/s11671-017-2242-2
J. Hong and Y. Q. Zhang, “Murine liver damage caused by exposure to nano-titanium dioxide,” Nanotecnology 27 (2016). https://doi.org/10.1088/0957-4484/27/11/112001
J. J. Wang, B. J. S. Sanderson, and H. Wang, “Cyto- and genotoxicity of ultrafine TiO2 particles in cultured human lymphoblastoid cells,” Mutat. Res. – Genet. Toxicol. Environ. Mutagen. 628, 99–106 (2007).
K. Mamulová Kutlákova, J. Tokarský, P. Kovář, S. Vojtěšková, A. Kovářová, B. Smetana, J. Kukutschová, P. Čapková, and V. Matějka, “Preparation and characterization of photoactive composite kaolinite/TiO2,” J. Hazard. Mater. 188, 212–220 (2011).
I. Zinicovscaia, S. S. Pavlov, M. V. Frontasyeva, A. L. Ivlieva, E. N. Petritskaya, D. A. Rogatkin, and V. A. Demin, “Accumulation of silver nanoparticles in mice tissues studied by neutron activation analysis,” J. Radioanal. Nucl. Chem. 318, 985–989 (2018).
M. V. Frontasyeva, Epithermal Neutron activation analysis at the IBR-2 reactor of the Frank laboratory of neutron physics at the Joint Institute for Nuclear Research (Dubna)," Phys. At. Nucl. 71, 1684–1693 (2008). https://doi.org/10.1134/S1063778808100049
A. L. Ivlieva, E. N. Petritskaya, D. A. Rogatkin, and V. A. Demin, “Methodical features of the application of Morris water maze for estimation of cognitive functions in animals,” Ross. Fiziol. Zh. 102, 13–17 (2016).
A. V. Terry, “Spatial navigation (water maze) tasks,” in Methods of Behavior Analysis in Neuroscience, Ed. by J. J. Buccafusco (CRC, Taylor and Francis, Boca Raton, 2000), pp. 153–166. http://www.ncbi.nlm.nih. gov/pubmed/21204326. Accessed November 8, 2020.
I. Zinicovscaia, D. Grozdov, N. Yushin, A. Ivlieva, E. Petritskaya, and D. Rogatkin, “Neutron activation analysis as a tool for tracing the accumulation of silver nanoparticles in tissues of female mice and their offspring,” J. Radioanal. Nucl. Chem. 322, 1079–1083 (2019).
J. Wang, G. Zhou, C. Chen, H. Yu, T. Wang, Y. Ma, G. Jia, Y. Gao, B. Li, J. Sun, Y. Li, F. Jiao, Y. Zhao, and Z. Chai, “Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration,” Toxicol. Lett. 168, 176–185 (2007).
J. Ferin, G. Oberdorster, and D. P. Penney, “Pulmonary retention of ultrafine and fine particles in rats,” Am. J. Respir. Cell Mol. Biol. 6, 535–542 (1992).
D. B. Warheit and E. M. Donner, “Risk assessment strategies for nanoscale and fine-sized titanium dioxide particles: Recognizing hazard and exposure issues,” Food Chem. Toxicol. 85, 138–147 (2015). https://doi.org/10.1016/j.fct.2015.07.001
L. Geraets, A. G. Oomen, P. Krystek, N. R. Jacobsen, H. Wallin, M. Laurentie, H. W. Verharen, E. F. A. Brandon, and W. H. de Jong, “Tissue distribution and elimination after oral and intravenous administration of different titanium dioxide nanoparticles in rats,” Part. Fibre Toxicol. 11 (30) (2014). https://doi.org/10.1186/1743-8977-11-30
H. R. H. Mohamed, “Estimation of TiO2 nanoparticle-induced genotoxicity persistence and possible chronic gastritis-induction in mice,” Food Chem. Toxicol. 83, 76–83 (2015).
F. Hong, N. Wu, Y. Zhou, L. Ji, T. Chen, and L. Wang, “Gastric toxicity involving alterations of gastritis-related protein expression in mice following long-term exposure to nano TiO2,” Food Res. Int. 95, 38–45 (2017).
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This work was supported by the Russian Foundation for Basic Research (RFBR) (grant no. 19-015-00145 А).
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Zinicovscaia, I., Ivlieva, A.L., Petritskaya, E.N. et al. Assessment of TiO2 Nanoparticles Accumulation in Organs and Their Effect on Cognitive Abilities of Mice. Phys. Part. Nuclei Lett. 18, 378–384 (2021). https://doi.org/10.1134/S1547477121030146
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DOI: https://doi.org/10.1134/S1547477121030146