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Involvement of histone methylation in the regulation of neuronal death

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Abstract

Neuronal death occurs in various physiological and pathological processes, and apoptosis, necrosis, and ferroptosis are three major forms of neuronal death. Neuronal apoptosis, necrosis, and ferroptosis are widely identified to involve the progress of stroke, Parkinson’s disease, and Alzheimer’s disease. A growing body of evidence has pointed out that neuronal death is tightly associated with expression of related genes and alteration of signaling molecules. In addition, recently, epigenetics has been increasingly focused on as a vital regulatory mechanism for neuronal apoptosis, necrosis, and ferroptosis, providing a new direction for treating nervous system diseases. Moreover, growing researches suggest that histone methylation or demethylation is involved in the processes of neuronal apoptosis, necrosis, and ferroptosis. These researches may imply that studying the potential roles of histone methylation is essential for treating the nervous system diseases. Here, we review potential roles of histone methylation and demethylation in neuronal death, which may give us a new direction in treating the nervous system diseases.

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Acknowledgements

We thank the National Natural Sciences Foundation of China for its support.

Funding

This project is supported by National Natural Sciences Foundation of China (grant number 81801168).

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  1. Department of Pathophysiology, School of Basic Medical Sciences, Xuzhou Medical University, Xuzhou, China

    Lei Zhang, Tai Zhou, Yaxin Su, Li He & Zhongcheng Wang

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  1. Lei Zhang
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ZW and LZ conceived and wrote the manuscript, TZ and YS edited the manuscript, and LH prepared the figures. All authors read and approved the final version of the manuscript. The authors declare that all data were generated in-house and that no paper mill was used.

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Correspondence to Zhongcheng Wang.

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Key points

1. H3K27me3 is involved in neuronal apoptosis, necrosis, and ferroptosis.

2. The role of H3K4me3 is clear in neuronal ferroptosis, but elusive in the others.

3. Appropriate studies should be conducted to elucidate the mechanisms of histone methylation in neuronal death.

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Zhang, L., Zhou, T., Su, Y. et al. Involvement of histone methylation in the regulation of neuronal death. J Physiol Biochem 79, 685–693 (2023). https://doi.org/10.1007/s13105-023-00978-w

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