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Nutrient regulation of enteroendocrine cellular activity linked to cholecystokinin gene expression and secretion

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Abstract

The hormone cholecystokinin is produced by the enteroendocrine I cells in the intestine, and it plays an important role in a number of physiological processes including digestion and food intake. Recent data suggest that cholecystokinin gene expression and protein secretion are regulated by macronutrients. The mechanism involves a change in intracellular levels of cAMP and Ca+2, brought about by the activity of a number of nutrient-responsive G protein-coupled receptors, nutrient transporters, ion channels and intracellular enzymes. How these intracellular responses could lead to gene expression and protein secretion are discussed along with new directions for future investigation.

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Authors and Affiliations

  1. Food for Health Ireland, Teagasc, Moorepark Food Research Centre, Fermoy, County Cork, Ireland

    K. N. Nilaweera, L. Giblin & R. P. Ross

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  1. K. N. Nilaweera
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  2. L. Giblin
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Correspondence to K. N. Nilaweera.

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Nilaweera, K.N., Giblin, L. & Ross, R.P. Nutrient regulation of enteroendocrine cellular activity linked to cholecystokinin gene expression and secretion. J Physiol Biochem 66, 85–92 (2010). https://doi.org/10.1007/s13105-010-0012-z

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