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Improving Reperfusion Therapies in the Era of Mechanical Thrombectomy

  • SI: Challenges and Controversies in Translational Stroke Research
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Abstract

Recent positive clinical trials using mechanical thrombectomy proved that endovascular recanalization is an effective treatment for patients with acute stroke secondary to large vessel occlusions. The trials offer definite evidence that in acute ischemia recanalization is a powerful predictor of good outcome. However, even in the era of rapid and effective recanalization using endovascular approaches, the percentage of patients with good outcomes varies between 33 and 71 %. In addition, the number of patients who are eligible for endovascular thrombectomy is small and usually based on having salvageable tissue on imaging. There is therefore room for improvement to both enhance the effectiveness of current practice and expand treatment to a larger subset of stroke patients. In this review, we highlight some of the most promising approaches to improve endovascular therapy by combining with strategies to enhance collateral perfusion and vascular protection.

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  1. Miami Cardiac and Vascular Institute and Neuroscience Center, Baptist Hospital, Miami, FL, USA

    Italo Linfante

  2. Department of Neurological Sciences and Pharmacology, University of Vermont College of Medicine, 149 Beaumont Ave.; HSRF 416A, Burlington, VT, 05405, USA

    Marilyn J. Cipolla

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  1. Italo Linfante
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Correspondence to Marilyn J. Cipolla.

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M. J. C. is funded by the National Institutes of Health grants R01 NS045940, R01 NS093289, P01 HL095488, the Preeclampsia Foundation, and the Totman Medical Research Trust.

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I. L. is consultant for Medtronic/Covidien, Stryker, Codman, Penumbra, and stockholder for Surpass and InNeuroCo.

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This article does not contain any studies with human participants or animals performed by the authors.

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Linfante, I., Cipolla, M.J. Improving Reperfusion Therapies in the Era of Mechanical Thrombectomy. Transl. Stroke Res. 7, 294–302 (2016). https://doi.org/10.1007/s12975-016-0469-3

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