Abstract
We analyzed the projects and published studies funded by NSFC (National Natural Science Foundation of China) in the field of stoke. Further more, we searched the published papers supported by NSFC in the last decade using the keywords of "stroke" or "cerebrovascular disease" and analyzed the results according to the topics associated with the mechanisms of ischemic brain injury, novel techniques and new drugs, medical imaging, translational medicine, and traditional Chinese medicine.
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References
Shi F-D, Jia J-P. Neurology and neurologic practice in China. Neurology. 2011;77(22):1986–92.
Wang L, Zhang L, Chen ZB, Wu JY, Zhang X, Xu Y. Icariin enhances neuronal survival after oxygen and glucose deprivation by increasing SIRT1. Eur J Pharmacol. 2009;609(1-3):40–4. doi:10.1016/j.ejphar.2009.03.033.
Yang QW, Li JC, Lu FL, Wen AQ, Xiang J, Zhang LL, et al. Upregulated expression of toll-like receptor 4 in monocytes correlates with severity of acute cerebral infarction. J Cereb Blood Flow Metab. 2008;28(9):1588–96. doi:10.1038/jcbfm.2008.50.
Wang XX, Pei L, Yan HL, Wang ZP, Wei N, Wang S, et al. Intervention of death-associated protein kinase 1-p53 interaction exerts the therapeutic effects against stroke. Stroke. 2014;45(10):3089–91. doi:10.1161/strokeaha.114.006348.
Chen ZB, Huang DQ, Niu FN, Zhang X, Li EG, Xu Y. Human urinary kallidinogenase suppresses cerebral inflammation in experimental stroke and downregulates nuclear factor-kappaB. J Cereb Blood Flow Metab Off J Int Soc Cereb Blood Flow Metab. 2010;30(7):1356–65. doi:10.1038/jcbfm.2010.19.
Han L, Yin K, Zhang S, Wu Z, Wang C, Zhang Q, et al. Dalesconols B inhibits lipopolysaccharide induced inflammation and suppresses NF-kappaB and p38/JNK activation in microglial cells. Neurochem Int. 2013;62(7):913–21. doi:10.1016/j.neuint.2013.03.003.
Niu F, Zhang X, Chang L, Wu J, Yu Y, Chen J, et al. Trichostatin A enhances OGD-astrocyte viability by inhibiting inflammatory reaction mediated by NF-kappaB. Brain Res Bull. 2009;78(6):342–6. doi:10.1016/j.brainresbull.2008.11.010.
Niu FN, Zhang X, Hu XM, Chen J, Chang LL, Li JW, et al. Targeted mutation of Fas ligand gene attenuates brain inflammation in experimental stroke. Brain Behav Immun. 2012;26(1):61–71. doi:10.1016/j.bbi.2011.07.235.
Hou SZ, Li Y, Zhu XL, Wang ZY, Wang X, Xu Y. Ameliorative effects of diammonium glycyrrhizinate on inflammation in focal cerebral ischemic-reperfusion injury. Brain Res. 2012;1447:20–7. doi:10.1016/j.brainres.2012.02.011.
Chen HZ, Guo S, Li ZZ, Lu YY, Jiang DS, Zhang R, et al. A critical role for interferon regulatory factor 9 in cerebral ischemic stroke. J Neurosci. 2014;34(36):11897–912. doi:10.1523/jneurosci.1545-14.2014.
Huang J, Li YN, Tang YH, Tang GH, Yang GY, Wang YT. CXCR4 antagonist AMD3100 protects blood-brain barrier integrity and reduces inflammatory response after focal ischemia in mice. Stroke. 2013;44(1):190–7. doi:10.1161/strokeaha.112.670299.
Zhang XN, Yan HJ, Yuan Y, Gao JQ, Shen Z, Cheng Y, et al. Cerebral ischemia-reperfusion-induced autophagy protects against neuronal injury by mitochondrial clearance. Autophagy. 2013;9(9):1321–33. doi:10.4161/auto.25132.
Liao WB, Xie J, Zhong J, Liu YJ, Du L, Zhou B, et al. Therapeutic effect of human umbilical cord multipotent mesenchymal stromal cells in a rat model of stroke. Transplantation. 2009;87(3):350–9. doi:10.1097/TP.0b013e318195742e.
Jiang M, Lv L, Ji HF, Yang XL, Zhu W, Cai LY, et al. Induction of pluripotent stem cells transplantation therapy for ischemic stroke. Mol Cell Biochem. 2011;354(1-2):67–75. doi:10.1007/s11010-011-0806-5.
Li HY, Gao AJ, Feng DX, Wang Y, Zhang L, Cui YH, et al. Evaluation of the protective potential of brain microvascular endothelial cell autophagy on blood-brain barrier integrity during experimental cerebral ischemia-reperfusion injury. Transl Stroke Res. 2014;5(5):618–26. doi:10.1007/s12975-014-0354-x.
Wang QY, Chao DM, Chen T, Sandhu H, Xia Y. delta-Opioid receptors and inflammatory cytokines in hypoxia: differential regulation between glial and neuron-like cells. Transl Stroke Res. 2014;5(4):476–83. doi:10.1007/s12975-014-0342-1.
Zhou L, Li F, Xu HB, Luo CX, Wu HY, Zhu MM, et al. Treatment of cerebral ischemia by disrupting ischemia-induced interaction of nNOS with PSD-95. Nat Med. 2010;16(12):1439–U123. doi:10.1038/nm.2245.
Wang P, Guan YF, Du H, Zhai QW, Su DF, Miao CY. Induction of autophagy contributes to the neuroprotection of nicotinamide phosphoribosyltransferase in cerebral ischemic stroke. Autophagy. 2012;8(1):77–87. doi:10.4161/auto.8.1.18274.
Liu X, An CY, Jin P, Liu XS, Wang LH. Protective effects of cationic bovine serum albumin-conjugated PEGylated tanshinone IIA nanoparticles on cerebral ischemia. Biomaterials. 2013;34(3):817–30. doi:10.1016/j.biomaterials.2012.10.017.
Liu X, Ye M, An CY, Pan LQ, Ji LT. The effect of cationic albumin-conjugated PEGylated tanshinone IIA nanoparticles on neuronal signal pathways and neuroprotection in cerebral ischemia. Biomaterials. 2013;34(28):6893–905. doi:10.1016/j.biomaterials.2013.05.021.
Lu YM, Huang JY, Wang H, Lou XF, Liao MH, Hong LJ, et al. Targeted therapy of brain ischaemia using Fas ligand antibody conjugated PEG-lipid nanoparticles. Biomaterials. 2014;35(1):530–7. doi:10.1016/j.biomaterials.2013.09.093.
Wen XH, Wang Y, Zhang F, Zhang X, Lu LJ, Shuai XT, et al. In vivo monitoring of neural stem cells after transplantation in acute cerebral infarction with dual-modal MR imaging and optical imaging. Biomaterials. 2014;35(16):4627–35. doi:10.1016/j.biomaterials.2014.02.042.
Li QY, Tang GH, Xue SH, He XS, Miao P, Li YN, et al. Silica-coated superparamagnetic iron oxide nanoparticles targeting of EPCs in ischemic brain injury. Biomaterials. 2013;34(21):4982–92. doi:10.1016/j.biomaterials.2013.03.030.
Wang Q, Peng Y, Chen SY, Gou XC, Hu B, Du J, et al. Pretreatment with electroacupuncture induces rapid tolerance to focal cerebral ischemia through regulation of endocannabinoid system. Stroke. 2009;40(6):2157–64. doi:10.1161/strokeaha.108.541490.
Wang QA, Li XY, Chen YK, Wang F, Yang QZ, Chen SY, et al. Activation of epsilon protein kinase c-mediated anti-apoptosis is involved in rapid tolerance induced by electroacupuncture pretreatment through cannabinoid receptor type 1. Stroke. 2011;42(2):389–96. doi:10.1161/strokeaha.110.597336.
Dong WP, Li NL, Gao DK, Zhen HN, Zhang X, Li FF. Resveratrol attenuates ischemic brain damage in the delayed phase after stroke and induces messenger RNA and protein express for angiogenic factors. J Vasc Surg. 2008;48(3):709–14. doi:10.1016/j.jvs.2008.04.007.
Loh KP, Qi J, Tan BKH, Liu XH, Wei BG, Zhu YZ. Leonurine protects middle cerebral artery occluded rats through antioxidant effect and regulation of mitochondrial function. Stroke. 2010;41(11):2661–8. doi:10.1161/strokeaha.110.589895.
Qi ZF, Yan F, Shi WJ, Zhang CC, Dong W, Zhao YM, et al. AKT-Related Autophagy contributes to the neuroprotective efficacy of hydroxysafflor yellow A against ischemic stroke in rats. Transl Stroke Res. 2014;5(4):501–9. doi:10.1007/s12975-014-0346-x.
Li J, Zhang S, Lu M, Chen Z, Chen C, Han L, et al. Hydroxysafflor yellow A suppresses inflammatory responses of BV2 microglia after oxygen-glucose deprivation. Neurosci Lett. 2013;535:51–6. doi:10.1016/j.neulet.2012.12.056.
Wang L, Yu CS, Chen H, Qin W, He Y, Fan FM, et al. Dynamic functional reorganization of the motor execution network after stroke. Brain. 2010;133:1224–38. doi:10.1093/brain/awq043.
Li MH, Cheng YS, Li YD, Fang C, Chen SW, Wang W, et al. Large-cohort comparison between three-dimensional time-of-flight magnetic resonance and rotational digital subtraction angiographies in intracranial aneurysm detection. Stroke. 2009;40(9):3127–9. doi:10.1161/strokeaha.109.553800.
Yan SQ, Hu HT, Shi ZH, Zhang XT, Zhang S, Liebeskind DS, et al. Morphology of susceptibility vessel sign predicts middle cerebral artery recanalization after intravenous thrombolysis. Stroke. 2014;45(9):2795–7. doi:10.1161/strokeaha.114.006144.
Shi ZS, Loh Y, Liebeskind DS, Saver JL, Gonzalez NR, Tateshima S, et al. Leukoaraiosis predicts parenchymal hematoma after mechanical thrombectomy in acute ischemic stroke. Stroke. 2012;43(7):1806–11. doi:10.1161/strokeaha.111.649152.
Lou M, Al-Hazzani A, Goddeau RP, Novak V, Selim M. Relationship between white-matter hyperintensities and hematoma volume and growth in patients with intracerebral hemorrhage. Stroke. 2010;41(1):34–40. doi:10.1161/strokeaha.109.564955.
Liu J, Xu Q, Wang H, Wang R, Hou XY. Neuroprotection of ischemic postconditioning by downregulating the postsynaptic signaling mediated by kainate receptors. Stroke. 2013;44(7):2031–5. doi:10.1161/strokeaha.113.680181.
Liu XR, Zhao SF, Liu F, Kang J, Xiao A, Li F, et al. Remote ischemic postconditioning alleviates cerebral ischemic injury by attenuating endoplasmic reticulum stress-mediated apoptosis. Transl Stroke Res. 2014;5(6):692–700. doi:10.1007/s12975-014-0359-5.
Meng R, Asmaro K, Meng L, Liu Y, Ma C, Xi CJ, et al. Upper limb ischemic preconditioning prevents recurrent stroke in intracranial arterial stenosis. Neurology. 2012;79(18):1853–61. doi:10.1212/WNL.0b013e318271f76a.
Liu XQ, Sheng R, Qin ZH. The neuroprotective mechanism of brain ischemic preconditioning. Acta Pharmacol Sin. 2009;30(8):1071–80. doi:10.1038/aps.2009.105.
Lou M, Safdar A, Mehdiratta M, Kumar S, Schlaug G, Caplan L, et al. The HAT Score A simple grading scale for predicting hemorrhage after thrombolysis. Neurology. 2008;71(18):1417–23. doi:10.1212/01.wnl.0000330297.58334.dd.
Wang LX, Fan WY, Cai P, Fan MC, Zhu XM, Dai YQ, et al. Recombinant ADAMTS13 reduces tissue plasminogen activator-induced hemorrhage after stroke in mice. Ann Neurol. 2013;73(2):189–98. doi:10.1002/ana.23762.
Jia DM, Chen ZB, Zhang MJ, Yang WJ, Jin JL, Xia YQ, et al. CYP2C19 Polymorphisms and antiplatelet effects of clopidogrel in acute ischemic stroke in china. Stroke. 2013;44(6):1717–9. doi:10.1161/strokeaha.113.000823.
Lin YJ, Li JW, Zhang MJ, Qian L, Yang WJ, Zhang CL, et al. The association between CYP2C19 genotype and of in-stent restenosis among patients with vertebral artery stent treatment. CNS Neurosci Ther. 2014;20(2):125–30. doi:10.1111/cns.12173.
Zhao H, Li QJ, Lu MR, Shao Y, Li JW, Xu Y. ABCD(2) Score may discriminate minor stroke from TIA on patient admission. Transl Stroke Res. 2014;5(1):128–35. doi:10.1007/s12975-013-0286-x.
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Lijun Zhu and Dongsheng He contributed equally to this work.
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Zhu, L., He, D., Han, L. et al. Stroke Research in China over the Past Decade: Analysis of NSFC Funding. Transl. Stroke Res. 6, 253–256 (2015). https://doi.org/10.1007/s12975-015-0404-z
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DOI: https://doi.org/10.1007/s12975-015-0404-z