Skip to main content

Advertisement

SpringerLink
Log in

Effect of Molecular Characteristics and Morphology on Mechanical Performance and Biocompatibility of PLA-Based Spongious Scaffolds

  • Published:
BioNanoScience Aims and scope Submit manuscript

Abstract

The effect of molecular characteristics and morphology on mechanical performance and biocompatibility of PLA-based spongious scaffolds was studied. PLLA and PDLLA with different molecular weight were studied. It was shown that the structure and the mechanical properties of PLA sponges slightly depend on the molecular mass of the polymer. In the contrary, porosity of the sponge-like material has great effect on its mechanical properties. Biocompatibility tests showed that PLLA provide better matrix behavior compared to PDLLA for the stem cells from human exfoliated deciduous teeth.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8

Similar content being viewed by others

References

  1. Xue, J., Lin, H., Bean, A., Tang, Y., Tan, J., Tuan, R., & Wang, B. (2017). One-step fabrication of bone morphogenetic protein-2 gene-activated porous poly-L-lactide scaffold for bone induction. Molecular Therapy — Methods & Clinical Development, 7, 50–59. https://doi.org/10.1016/j.omtm.2017.08.008.

    Article  Google Scholar 

  2. Bukharova, T. B., Volkov, A. V., Antonov, E. N., Vihrova, E. B., Popova, A. V., Popov, V. K., & Goldstein, D. V. (2013). Tissue-engineered construction made of adipose derived multipotent mesenchymal stromal cells, polylactide scaffolds and platelet gel. Gene and Cells, 8(4), 61–68.

    Google Scholar 

  3. Lin, X., Bo, W., Yang, G., & Gauthier, M. (2012). Poly (lactic acid)-based biomaterials: synthesis, modification and applications. Biomedical Science, Engineering and Technology, 11, 247–282. https://doi.org/10.5772/23927.

    Article  Google Scholar 

  4. Antonov, E. N., Bukharova, T. B., Dunaev, A. G., Krotova, L. I., Nifant’ev, I. E., Popov, V. K., & Shlyakhtin, A. V. (2017). New “old” polylactides for tissue engineering constructions. Inorganic Materials: Applied Research, 8(5), 704–712. https://doi.org/10.1134/S2075113317050033.

    Article  Google Scholar 

  5. Middleton, J. C., & Tipton, A. J. (2000). Synthetic biodegradable polymers as orthopedic devices. Biomaterials, 21(23), 2335–2346. https://doi.org/10.1016/S0142-9612(00)00101-0.

    Article  Google Scholar 

  6. Ikada, Y., & Tsuji, H. (2000). Biodegradable polyesters for medical and ecological applications. Macromolecular Rapid Communications, 21(3), 117–132. https://doi.org/10.1002/(SICI)1521-3927(20000201)21:3<117::AID-MARC117>3.0.CO;2-X.

    Article  Google Scholar 

  7. Sarasua, J. R., Lo’pez-Rodrı’guez, N., Zuza, E., Petisco, S., Castro, B., del Olmo, M., Palomares, T., & Alonso-Varona, A. (2011). Crystallinity assessment and in vitro cytotoxicity of polylactide scaffolds for biomedical applications. Journal of Materials Science: Materials in Medicine, 22, 2513–2523. https://doi.org/10.1007/s10856-011-4425-1.

    Article  Google Scholar 

  8. Yi, Q., Wen, X., Li, L., He, B., Nie, Y., Wu, Y., Zhang, Z., & Gu, Z. (2009). The chiral effects on the responses of osteoblastic cells to the polymeric substrates. European Polymer Journal, 45, 1970–1978. https://doi.org/10.1016/j.eurpolymj.2009.04.018.

    Article  Google Scholar 

Download references

Funding

This work was supported by RSF (grant no. 16-15-00298).

Author information

Authors and Affiliations

  1. National Research Center “Kurchatov Institute”, Bld. 1, Akademika Kurchatova pl., Moscow, 123182, Russia

    T. E. Grigoriev, Y. D. Zagoskin, V. I. Gomzyak & S. N. Chvalun

  2. Moscow Technological University (M.V. Lomonosov Institute of Fine Chemical Technologies), Moscow, 119571, Russia

    T. E. Grigoriev & V. I. Gomzyak

  3. Research Centre for Medical Genetics, Bld. 1, Moskvorechie St., Moscow, 115522, Russia

    T. B. Bukharova, A. V. Vasilyev, G. E. Leonov, D. I. Salikhova, E. V. Galitsyna, O. V. Makhnach & D. V. Goldshtein

  4. Central Research Institute of Dental and Maxillofacial Surgery, Bld. 16, Timura Frunze St., Moscow, 119034, Russia

    A. V. Vasilyev, G. E. Leonov, V. S. Kuznetsova, D. I. Salikhova, E. V. Galitsyna, D. V. Goldshtein & A. A. Kulakov

  5. National Medical Center of Phthisiopulmonology and Infectious Diseases, Ministry of Health of the Russian Federation, Bld. 4, Dostoevsky St., Moscow, 127473, Russia

    K. V. Tokaev

  6. A foundation of the Russian Academy of Sciences, Enikolopov Institute of Synthetic Polymeric Materials, Bld. 70, Profsoyuznaya St., Moscow, 117393, Russia

    S. N. Chvalun

  7. Financial University under the Government of the Russian Federation, Bld. 49, GSP-3, Leningradsky Prospekt, Moscow, 125993, Russia

    M. A. Paltsev

Authors
  1. T. E. Grigoriev
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. T. B. Bukharova
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. V. Vasilyev
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. G. E. Leonov
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Y. D. Zagoskin
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. V. S. Kuznetsova
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. V. I. Gomzyak
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. D. I. Salikhova
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. E. V. Galitsyna
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. O. V. Makhnach
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. K. V. Tokaev
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. S. N. Chvalun
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. D. V. Goldshtein
    View author publications

    You can also search for this author in PubMed Google Scholar

  14. A. A. Kulakov
    View author publications

    You can also search for this author in PubMed Google Scholar

  15. M. A. Paltsev
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to T. E. Grigoriev.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Grigoriev, T.E., Bukharova, T.B., Vasilyev, A.V. et al. Effect of Molecular Characteristics and Morphology on Mechanical Performance and Biocompatibility of PLA-Based Spongious Scaffolds. BioNanoSci. 8, 977–983 (2018). https://doi.org/10.1007/s12668-018-0557-9

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12668-018-0557-9

Keywords

Search

Navigation