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Contraction of Blood Clots Is Impaired in Deep Vein Thrombosis

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Abstract

The goal of this study was to investigate the connection of blood clot contraction (retraction) with deep vein thrombosis. In the blood of deep vein thrombosis patients, the extent and rate of clot contraction is dramatically reduced compared to healthy subjects, especially in deep vein thrombosis complicated with pulmonary embolism. Clinical and laboratory correlations suggest that impaired contraction of blood clots and thrombi is an important pathogenic mechanism that affects the course and outcomes of deep vein thrombosis.

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Authors and Affiliations

  1. Kazan Federal University, 18 Kremlyovskaya St, Kazan, 420008, Russia

    Alina D. Peshkova, Le Minh Giang & Rustem I. Litvinov

  2. Interregional Clinical Diagnostic Center, 12a Karbishev St, Kazan, 420101, Russia

    Dmitry V. Malyasev & Roman A. Bredikhin

  3. Kazan State Medical University, 49 Butlerov St, Kazan, 420012, Russia

    Dmitry V. Malyasev & Roman A. Bredikhin

  4. University of Pennsylvania School of Medicine, 421 Curie Blvd, Philadelphia, PA, 19104, USA

    Rustem I. Litvinov

Authors
  1. Alina D. Peshkova
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  2. Dmitry V. Malyasev
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  3. Roman A. Bredikhin
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  4. Le Minh Giang
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  5. Rustem I. Litvinov
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Corresponding author

Correspondence to Rustem I. Litvinov.

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Blood of the DVT patients and donors was withdrawn using a standard protocol approved by the Ethical Committee of the Interregional Clinical Diagnostic Center (ICDC, Kazan, Russia).

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Peshkova, A.D., Malyasev, D.V., Bredikhin, R.A. et al. Contraction of Blood Clots Is Impaired in Deep Vein Thrombosis. BioNanoSci. 6, 457–459 (2016). https://doi.org/10.1007/s12668-016-0251-8

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  • DOI: https://doi.org/10.1007/s12668-016-0251-8

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