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High Serum Tumor Necrosis Factor Receptor 1 Levels Are Related to Risk of Low Intrinsic Capacity in Elderly Adults

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The journal of nutrition, health & aging

Abstract

Objectives

To explore the association between inflammatory cytokines and intrinsic capacity in older adults.

Method

Data were retrieved from the Cardiovascular Health, Cognition and Aging Study. A total of 130 participants aged 60–99 years (mean age 73.11±9.02 years) were recruited. Intrinsic capacity was assessed by the five domains recommended by the World Health Organization: locomotion, cognition, vitality, sensory and psychological domains. Circulating interleukin-6, tumor necrosis factor receptor 1 (TNFR1), insulin-like growth factor-1, and vaspin levels were measured. Logistic regression was conducted for factors associated with intrinsic capacity decline.

Results

Intrinsic capacity decline was associated with older age, kidney diseases, olfactory disturbances and lower grip strength. Logistic regression showed that circulating TNFR1 was independently associated with intrinsic capacity decline after adjustments for age, sex, education, chronic diseases, grip strength, and physical activity.

Conclusion

Elevated circulating TNFR1 levels are independently associated with declined intrinsic capacity, suggesting that chronic inflammation may underlie intrinsic capacity decline.

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Acknowledgments

This work was supported by the following grants: National Key R&D Program of China (2018YFC1312001), the National Natural Science Foundation of Beijing (7202059), Beijing Municipal Hospital Scientific Research Training Project (PX2020036), and Milstein Medical Asian American Partnership Foundation Project Award in Geriatrics (2018).

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Authors and Affiliations

  1. Department of Geriatrics, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, 45 Changchun Street, Xicheng District, Beijing, 100053, China

    Lina Ma, P. Liu, Y. Zhang, G. Sha, L. Zhang & Y. Li

Authors
  1. Lina Ma
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  2. P. Liu
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  3. Y. Zhang
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  4. G. Sha
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  5. L. Zhang
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  6. Y. Li
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Corresponding author

Correspondence to Lina Ma.

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Disclosure statement: The authors declare that they have no competing interests

Ethical standards: The present study followed the ethical guideline of the declaration of Helsinki and was approved by the Ethics Committees.

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Ma, L., Liu, P., Zhang, Y. et al. High Serum Tumor Necrosis Factor Receptor 1 Levels Are Related to Risk of Low Intrinsic Capacity in Elderly Adults. J Nutr Health Aging 25, 416–418 (2021). https://doi.org/10.1007/s12603-020-1533-y

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  • DOI: https://doi.org/10.1007/s12603-020-1533-y

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