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Comparative study for the association of mitochondrial haplogroup F+ and metabolic syndrome between longevity and control population in Guangxi Zhuang Autonomous Region, China

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The journal of nutrition, health & aging

Abstract

Background

Our previous study suggested that mitochondrial haplogroup F (mtDNA F) was a longevity-associated biomarker, but the effect of mitochondrial haplogroup F on longevity individuals with metabolic syndrome (MetS) was not clear. Thus we explored the association between mtDNA F and MetS among longevity and control population in Guangxi Zhuang Autonomous Region, China.

Method

A total of 793 individuals consisting of 307 long-lived participants and 486 local healthy controls were involved in this study. Genotypes of mtDNA F were amplified by polymerase chain reaction and Sanger sequenced. MetS was defined according to the revised National Cholesterol Education Program’s Adult Treatment Panel III (NCEP ATPIII ) criteria.

Results

The prevalence of MetS in longevity group (28.0%) was higher than that (18.5%) in control group (P=0.002). Through the case-control stratify analysis, the prevalence of MetS in mtDNA F+ longevity individuals (29.8%) was 4.6 fold higher than that (5.3%) in local control group (P<0.001). However, after further longevity-only analysis, no association between MetS and mtDNA F+ in longevity group was observed (P=0.167). Following same analysis of two variables in control group, we found that the prevalence of MetS in mtDNA F- (95.8%) was higher than that in mtDNA F+ (5.3%); conversely, the prevalence of non-metabolic syndrome (NMetS) in mtDNA F+ (94.7%) was markedly higher than that in mtDNA F- (4.2%) (P<0.001).

Conclusion

We demonstrated that mtDNA F+, as a molecuar biomarker, might not only confer beneficial effect to resistance against MetS but also function as a positive factor for long-life span among the population in Guangxi Zhuang Autonomous Region, China.

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Author notes

  1. These authors contributed equally to this work.

Authors and Affiliations

  1. Department of Neurology, Jiangbin Hospital, Nanning, Guangxi, P.R. China

    C. Hu, X. He & Q. Liang

  2. The MOH key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology, No.1 DaHua Road, Dong Dan, 100730, Beijing, P.R. China

    X. Li, L. Sun, Z. Lv, H. Yuan, X. Zhu, Y. Yang, Q. Zhou & Ze Yang

  3. Department of Cardiothoracic Surgery, Guangxi Maternal and Child Health Hospital, Nanning, Guangxi, P.R. China

    C. Zheng

  4. Yongfu committee of the Chinese people’s political consultative conference, Yongfu, Guangxi, P.R. China

    Z. Huang

  5. Lab of Genetics and Metabolism, Beijing Obstetrics and Gynecology Hospital, Beijing, P.R. China

    K. Qi

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  1. C. Hu
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Correspondence to Ze Yang.

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Hu, C., He, X., Li, X. et al. Comparative study for the association of mitochondrial haplogroup F+ and metabolic syndrome between longevity and control population in Guangxi Zhuang Autonomous Region, China. J Nutr Health Aging 22, 302–307 (2018). https://doi.org/10.1007/s12603-017-0915-2

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  • DOI: https://doi.org/10.1007/s12603-017-0915-2

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