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Adherence to the Mediterranean Diet and all-cause mortality risk in an elderly Italian population: Data from the ILSA study

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The journal of nutrition, health & aging

Abstract

Objective

The aim of this study was to evaluate adherence to the Mediterranean Diet (MD) and its association with all-cause mortality in an elderly Italian population.

Design

Data analysis of a longitudinal study of a representative, age stratified, population sample.

Setting

Study data is based upon the Italian Longitudinal Study on Aging (ILSA) a prospective, community-based cohort study. The baseline evaluation was carried out in 1992 and the follow-up in 1996 and 2000.

Participant

Participant food intake assessment was available at baseline for 4,232 subjects; information on survival was available for 2,665 at the 2000 follow-up.

Measurements

Adherence to the MD was evaluated with an a priori score based on the Mediterranean pyramid components. Cox proportional hazard models were used to assess the relationship between the MD score and all-cause mortality. Six hundred and sixty five subjects had died at the second follow-up (identified up to the first and second follow-up together; mean follow-up: 7.1±2.6 years).

Results

At the 2000 follow-up, adjusting for other confounding factors, participants with a high adherence to MD (highest tertile of the MD score distribution) had an all-cause mortality risk that was of 34% lower with respect to the subjects with low adherence (Hazard Ratio=0.66; 95% CI: 0.49-0.90; p=0.0144).

Conclusion

According to study results, a higher adherence to the MD was associated with a low all-cause mortality risk in an elderly Italian population.

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References

  1. Keys A, Menotti A, Karvonen MJ et al. The diet and 15-year death rate in the seven countries study. Am J Epidemiol 1986;124(6),903–915

    Article  CAS  PubMed  Google Scholar 

  2. Trichopoulou A, Martínez-González MA, Tong TY, Forouhi NG, Khandelwal S, Prabhakaran D, Mozaffarian D, de Lorgeril M.Serra-Majem L, Roman B, Estruch R. Definitions and potential health benefits of the Mediterranean diet: views from experts around the world. BMC Med 2014;24;12:112

    Article  Google Scholar 

  3. Martinez-Gonzalez MA, Bes-Rastrollo M. Dietary patterns, Mediterranean diet, and cardiovascular disease. Curr Opin Lipidol 2014;25(1):20–26

    Article  CAS  PubMed  Google Scholar 

  4. Martinez-Gonzalez MA, Bes-Rastrollo M, Serra-Majem L et al. Mediterranean food pattern and the primary prevention of chronic disease: recent developments. Nutr Rev 2009;67, Suppl1:S111–S116.

    Article  PubMed  Google Scholar 

  5. Sofi F, Macchi C, Abbate R et al. Mediterranean diet and health. Biofactors 2013;39(4),335–342

    Article  CAS  PubMed  Google Scholar 

  6. Sofi F, Abbate R, Gensini GF et al. Accruing evidence on benefits of adherence to the Mediterranean diet on health: an updated systematic review and meta-analysis. Am J Clin Nutr 2010;92(5),1189–1196

    Article  CAS  PubMed  Google Scholar 

  7. Jankovic N, Geelen A, Streppel MT, de Groot LC, Orfanos P, van den Hooven EH, Pikhart H, Boffetta P, Trichopoulou A, Bobak M, Bueno-de-Mesquita HB, Kee F, Franco OH, Park Y, Hallmans G, Tjønneland A, May AM, Pajak A, Malyutina S, Kubinova R, Amiano P, Kampman E, Feskens EJ. Adherence to a healthy diet according to the World Health Organization guidelines and all-cause mortality in elderly adults from Europe and the United States. Am J Epidemiol 2014;180(10):978–988

    Article  PubMed  PubMed Central  Google Scholar 

  8. Reedy J, Krebs-Smith SM, Miller PE, Liese AD, Kahle LL, Park Y, Subar AF. Higher diet quality is associated with decreased risk of all-cause, cardiovascular disease, and cancer mortality among older adults. J Nutr. 2014;144(6):881–889

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Atkins JL, Whincup PH, Morris RW, Lennon LT, Papacosta O, Wannamethee SG. High diet quality is associated with a lower risk of cardiovascular disease and allcause mortality in older men. J Nutr 2014;144(5):673–680

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Middleton G, Keegan R, Smith MF, Alkhatib A, Klonizakis M. Brief Report: Implementing a Mediterranean Diet Intervention into a RCT: Lessons Learned from a Non-Mediterranean Based Country. J Nutr Health Aging 2015;19(10):1019–1022

    Article  CAS  PubMed  Google Scholar 

  11. Trichopoulou A, Costacou T, Bamia C et al. Adherence to a Mediterranean diet and survival in a Greek population. N Engl J Med 2003;348(26), 2599–2608

    Article  PubMed  Google Scholar 

  12. Knoops KT, de Groot LC, Kromhout D et al. Mediterranean diet, lifestyle factors, and 10-year mortality in elderly European men and women: the HALE project. JAMA 2004;292,1433–1439

    Article  PubMed  Google Scholar 

  13. Trichopoulou A, Orfanos P, Norat T et al. Modified Mediterranean diet and survival: EPIC-elderly prospective cohort study. BMJ 2005;30, 330(7498), 991

    Article  PubMed  PubMed Central  Google Scholar 

  14. Prinelli F, Yannakoulia M, Anastasiou CA et al. Mediterranean diet and other lifestyle factors in relation to 20-year all-cause mortality: a cohort study in an Italian population. Br J Nutr 2015;113(6),1003–1011

    Article  CAS  PubMed  Google Scholar 

  15. Estruch R, Ros E, Salas-Salvadó J, Covas MI, Corella D, Arós F, Gómez-Gracia E, Ruiz-Gutiérrez V, Fiol M, Lapetra J, Lamuela-Raventos RM, Serra-Majem L, Pintó X, Basora J, Muñoz MA, Sorlí JV, Martínez JA, Martínez-González MA; PREDIMED Study Investigators. Primary prevention of cardiovascular disease with a Mediterranean diet. N Engl J Med 2013;368(14):1279–90.

    Article  CAS  PubMed  Google Scholar 

  16. Klonizakis M, Alkhatib A, Middleton G. Long-term effects of an exercise and Mediterranean diet intervention in the vascular function of an older, healthy population Microvasc Res 2014;95,103–107

    Article  PubMed  Google Scholar 

  17. Alkhatib A, Klonizakis M. Effects of exercise training and Mediterranean diet on vascular risk reduction in post-menopausal women Clin Hemorheol Microcirc 2014;57(1):33–47

    CAS  PubMed  Google Scholar 

  18. Sofi F, Macchi C, Abbate R et al. Mediterranean diet and health status: an updated meta-analysis and a proposal for a literature-based adherence score. Public Health Nutr 2014;17(12),2769–2782

    Article  PubMed  Google Scholar 

  19. Guyonnet S, Rolland Y. Screening for Malnutrition in Older People. Clin Geriatr Med 2015;31(3),429–437

    Article  PubMed  Google Scholar 

  20. European Nutrition for Health Alliance. Malnutrition within an ageing population: a call for action Report on the Inaugural Conference of the European Nutrition for Health Alliance. London: European Nutrition for Health Alliance, 2005.

    Google Scholar 

  21. Maggi S, Zucchetto M, Grigoletto F, et al. for the ILSA group. The Italian longitudinal study on aging (ILSA): design and methods. Aging Clin Exp Res 1994;6,464–473

    Article  CAS  Google Scholar 

  22. Folstein MF, Folstein SE, McHugh PR. Mini-mental State: a practical method for grading the cognitive state of patients for the clinician J Psychiatr Res 1975;12,189–198

    Article  CAS  PubMed  Google Scholar 

  23. Brink TL, Yesavage JA, Lum O et al. Screening tests for geriatric depression. Clinical Gerontologist 1982;1,37–43

    Article  Google Scholar 

  24. Katz S, Downs TD, Cash HR et al. Progress in development of the index of ADL. Gerontologist 1970;1,20–30

    Article  Google Scholar 

  25. Lawton MP, Brody EM. Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist 1969;9(3),179–186

    Article  CAS  PubMed  Google Scholar 

  26. The Italian Longitudinal Study on Aging Working Group. Prevalence of chronic diseases in older Italians: comparing self-reported and clinical diagnoses. International Journal of Epidemiology 1997;26,995–1002

    Article  Google Scholar 

  27. World Health Organization. International Statistical Classification of diseases, injuries, and causes of death, Ninth Revision. Geneva: WHO, 1975

    Google Scholar 

  28. Goulet J, Lamarche B, Nadeau G et al. Effect of a nutritional intervention promoting the Mediterranean food pattern on plasma lipids, lipoproteins and body weight in healthy French-Canadian women. Atherosclerosis 2003;170(1),115–124

    Article  CAS  PubMed  Google Scholar 

  29. Mitrou PN, Kipnis V, Thiébaut AC, Reedy J, Subar AF, Wirfält E, Flood A, Mouw T, Hollenbeck AR, Leitzmann MF, Schatzkin A. Mediterranean dietary pattern and prediction of all-cause mortality in a US population: results from the NIH-AARP Diet and Health Study. Arch Intern Med 2007;167(22):2461–8

    Article  PubMed  Google Scholar 

  30. Panagiotakos DB, Pitsavos C, Arvaniti F et al. Adherence to the Mediterranean food pattern predicts the prevalence of hypertension, hypercholesterolemia, diabetes and obesity, among healthy adults; the accuracy of the MedDietScore. Prev Med 2007;44(4),335–340

    Article  PubMed  Google Scholar 

  31. Martínez-Lapiscina EH, Clavero P, Toledo E et al. Mediterranean diet improves cognition: the PREDIMED-NAVARRA randomised trial. J Neurol Neurosurg Psychiatry 2013;84,1318–1325

    Article  PubMed  Google Scholar 

  32. Valls-Pedret C, Sala-Vila A, Serra-Mir M, Corella D, de la Torre R, Martínez-González MÁ, Martínez-Lapiscina EH, Fitó M, Pérez-Heras A, Salas-Salvadó J, Estruch R, Ros E. Mediterranean Diet and Age-Related Cognitive Decline: A Randomized Clinical JAMA Intern Med 2015;175(7):1094–103

    Article  PubMed  Google Scholar 

  33. Mosconi L, Murray J, Tsui WH, Li Y, Davies M, Williams S, Pirraglia E, Spector N, Osorio RS, Glodzik L, McHugh P, de Leon MJ. Mediterranean Diet and magnetic resonance imaging-assessed brain atrophy in cognitively normal individuals at risk for Alzheimer’s Disease. J Prev Alz Dis 2014;1(1):23–32

    CAS  Google Scholar 

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Correspondence to Marianna Noale.

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The authors contributed equally to the study.

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Limongi, F., Noale, M., Gesmundo, A. et al. Adherence to the Mediterranean Diet and all-cause mortality risk in an elderly Italian population: Data from the ILSA study. J Nutr Health Aging 21, 505–513 (2017). https://doi.org/10.1007/s12603-016-0808-9

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  • DOI: https://doi.org/10.1007/s12603-016-0808-9

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