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The Five-Times-Sit-to-stand test, a marker of global cognitive functioning among community-dwelling older women

  • JNHA: Clinical Neurosciences
  • Published:
The journal of nutrition, health & aging

Abstract

Objective

To determine whether there was an association between the Five-Times-Sit-to-Stand test (FTSS) and the global cognitive function assessed with Short-Portable-Mental-State-Questionnaire (SPMSQ) among the EPIDOS cohort.

Design

Cross-sectional study corresponding to the baseline assessment of the EPIDOS study.

Setting

Five French cities including Amiens, Lyon, Montpellier, Paris and Toulouse.

Participants

7421 community-dwelling older women (mean age 80.41±0.04 years).

Measurements

Time to achieve FTSS, and SPMSQ score. Age, body mass index, high number of comorbidities, cardiovascular risk factors, depression, regular physical activity, joint pain, quadriceps strength, visual acuity, use of psychoactive drugs, serum albumin, vitamin D deficiency (i.e., serum concentration <10ng/mL), and the influence of seasons and study centers were used as covariables. Subjects were divided into 2 groups according to SPMSQ score (either impaired < 8/10 or normal ≥ 8/10).

Results

Compared to their counterparts, the women with cognitive impairment (n=1190, mean 81.51±0.45years) took more time in performing FTSS (17.8±0.9seconds versus 16.1±0.3seconds, P < 0.001). There was a significant negative association of SPMSQ score with FTSS (Unadjusted β=−0.02(95%CI −0.03;−0.01), P<0.001; Fully Adjusted β=−0.03(95%CI −0.05;−0.01), P=0.003; Stepwise Backward Adjusted β=−0.02(95%CI −0.04;−0.01), P=0.005), as well as with advance in age (β=−0.04, P=0.006) and vitamin D deficiency (β=−0.34, P=0.011). The FTSS limit value in predicting moderate cognitive impairment was set at 15 seconds by a sensitivity analysis (negative predictive value=86%).

Conclusion

We found a negative association of FTSS with global cognitive performance. Achieving FTSS in less than 15 seconds made unlikely the existence of a moderate cognitive impairment. FTSS could be used as a tool in primary care medicine to exclude moderate cognitive decline.

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Abbreviations

FTSS:

Five-Times-Sit-to-Stand test

SPMSQ:

Short Portable Mental State Questionnaire

EPIDOS:

EPIDémiologie de l’OStéoporose study

BMI:

Body Mass Index

3MS:

Modified Mini Mental State

MMSE:

Mini Mental State Examination

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Authors and Affiliations

  1. Department of Internal Medicine and Geriatrics, Angers University Hospital, Angers University Memory Center; UPRES EA 2646, University of Angers, UNAM, Angers, France

    Cédric Annweiler, B. Fantino & O. Beauchet

  2. Department IMER, Lyon University Hospital; EA 4129, RECIF, University of Lyon, Inserm, U831, Lyon, France

    A. -M. Schott

  3. Department of Geriatrics, Toulouse University Hospital; INSERM U558, University of Toulouse III, Toulouse, France

    G. Abellan Van Kan & Y. Rolland

  4. Department of Internal Medicine and Geriatrics, Montpellier University Hospital, University of Montpellier 1, Montpellier, France

    H. Blain

  5. Department of Rehabilitation and Geriatrics, Geneva University Hospitals; University of Geneva, Geneva, Switzerland

    F. R. Herrmann

  6. Department of Internal Medicine and Geriatrics, Angers University Hospital, 49933, Angers Cedex 9, France

    Cédric Annweiler

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  1. Cédric Annweiler
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  2. A. -M. Schott
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  3. G. Abellan Van Kan
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Correspondence to Cédric Annweiler.

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Annweiler, C., Schott, A.M., Abellan Van Kan, G. et al. The Five-Times-Sit-to-stand test, a marker of global cognitive functioning among community-dwelling older women. J Nutr Health Aging 15, 271–276 (2011). https://doi.org/10.1007/s12603-011-0037-1

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  • DOI: https://doi.org/10.1007/s12603-011-0037-1

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