Abstract
Purpose
To investigate the frequency and type of drug related problems (DRPs) in geriatric patients (> 65 years), and to assess their contribution to hospital admission; to explore the appropriateness of drug therapy according to the Beers’ criteria.
Methods
Cross-sectional observational survey of 110 elderly patients admitted during three non-consecutive months to the geriatric ward of a university hospital. Explorative assessment of appropriateness of drug therapy prior to hospital admission based on the Beers’ criteria
Results
A DRP was the dominant reason for hospital admission in 14 out of the 110 patients (12.7%); for another 9 patients (8.2%), a DRP was partly contributing to hospital admission. For these 23 patients, adverse drug reactions and noncompliance were the most important types of DRPs. We found no relationship between drug related hospital admission and intake of a drug listed in the Beers criteria for inappropriate drug use in the elderly. Patients admitted for a DRP took more drugs before admission than patients admitted because of other reasons.
Conclusions
DRPs are an important cause for admission on the geriatric ward of our hospital. The drugs causing DRPs in this study were not those listed in the Beers list of inappropriate drugs in the elderly.
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References
Beijer HJM, de Blaey CJ. Hospitalisations caused by adverse drug reactions (ADR): a meta-analysis of observational studies. Pharmacy World & Science 2002; 24: 46–54
Chan M, Nicklason F, Vial JH. Adverse drug events as a cause of hospital admission in the elderly. Internal Medicine Journal 2001; 31: 199–205
Mannesse CK, Derkx FHM, de Ridder MAJ, et al. Contribution of adverse drug reactions to hospital admission of older patients. Age and Ageing 2000; 29: 35–39
Courtman B, Stallings S. Characterization of drug-related problems in elderly patients on admission to a medical ward. Can J Hosp Pharm 1995; 48: 161–166
Cunningham G, Dodd TRP, Grant DJ, et al. Drug-related problems in elderly patients admitted to Tayside hospitals, methods for prevention and subsequent reassessment. Age and Ageing 1997; 26: 375–382
Hallas J, Harvald B, Worm J, et al. Drug-Related Hospital Admissions — Results from An Intervention Program. European Journal of Clinical Pharmacology 1993; 45: 199–203
Howard RL, Avery AJ, Howard PD, et al. Investigation into the reasons for preventable drug related admissions to a medical admissions unit: observational study. Qual Saf Health Care 2003; 12: 280–285
Kaiser RM, Schmader KE, Pieper CF, et al. Therapeutic failure-related hospitalisations in the frail elderly. Drugs Aging 2006; 23: 579–586
Nelson KM, Talbert RL. Drug-related hospital admissions. Pharmacotherapy 1996; 16: 701–707
Hohl CM, Dankoff J, Colacone A, et al. Polypharmacy, adverse drug-related events, and potential adverse drug interactions in elderly patients presenting to an emergency department. Annals of Emergency Medicine 2001; 38: 666–671
Pirmohamed M, James S, Meakin S, et al. Adverse drug reactions as cause of admission to hospital: prospective analysis of 18 820 patients. BMJ 2004; 329: 15–19
Onder G, Pedone C, Landi F, et al. Adverse drug reactions as cause of hospital admissions: results from the Italian Group of Pharmacoepidemiology in the Elderly (GIFA). J Am Geriatr Soc 2002; 50: 1962–1968
van der Hooft CS, Sturkenboom MC, van Grootheest K, et al. Adverse drug reaction-related hospitalisations: a nationwide study in The Netherlands. Drug Saf 2006; 29: 161–168
Lindley CM, Tully MP, Paramsothy V, et al. Inappropriate Medication Is A Major Cause of Adverse Drug-Reactions in Elderly Patients. Age and Ageing 1992; 21: 294–300
Beers MH, Ouslander JG, Rollingher I, et al. Explicit criteria for determining inappropriate medication use in nursing home residents. UCLA Division of Geriatric Medicine. Arch Intern Med 1991; 151: 1825–1832
Beers MH. Explicit criteria for determining inappropriate medication use by the elderly. An update. Arch Intern Med 1997; 157: 1531–1536
Hallas J, Harvald B, Gram LF, et al. Drug related hospital admissions: the role of definitions and intensity of data collection, and the possibility of prevention. J Intern Med 1990; 228: 83–90
International monitoring of adverse reactions to drugs. Adverse reaction terminology. Uppsala: WHO Collaborating Centre for International Drug Monitoring. 2008
R Development Core Team (2007). R: a language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. ISBN 3-900051-07-0, http://www.R-project.org. 2008
van den Bemt PM, Egberts AC, Lenderink AW, et al. Risk factors for the development of adverse drug events in hospitalized patients. Pharm World Sci 2000; 22: 62–66
Field TS, Gurwitz JH, Avorn J, et al. Risk factors for adverse drug events among nursing home residents. Arch Intern Med 2001; 161: 1629–1634
Field TS, Gurwitz JH, Harrold LR, et al. Risk factors for adverse drug events among older adults in the ambulatory setting. J Am Geriatr Soc 2004; 52: 1349–1354
Hajjar ER, Hanlon JT, Artz MB, et al. Adverse drug reaction risk factors in older outpatients. Am J Geriatr Pharmacother 2003; 1: 82–89
Gurwitz JH, Rochon P. Improving the quality of medication use in elderly patients: a not-so-simple prescription. Arch Intern Med 2002; 162: 1670–1672
Onder G, Landi F, Cesari M, et al. Inappropriate medication use among hospitalized older adults in Italy: results from the Italian Group of Pharmacoepidemiology in the Elderly. Eur J Clin Pharmacol 2003; 59: 157–162
Hanlon JT, Schmader KE, Samsa GP, et al. A method for assessing drug therapy appropriateness. J Clin Epidemiol 1992; 45: 1045–1051
Spinewine A, Schmader KE, Barber N, et al. Appropriate prescribing in elderly people: how well can it be measured and optimised? Lancet 2007; 370: 173–184
Hanlon JT, Pieper CF, Hajjar ER, et al. Incidence and predictors of all and preventable adverse drug reactions in frail elderly persons after hospital stay. J Gerontol A Biol Sci Med Sci 2006; 61: 511–515
Ong SW, Fernandes OA, Cesta A, et al. Drug-related problems on hospital admission: relationship to medication information transfer. Ann Pharmacother 2006; 40: 408–413
Passarelli MC, Jacob-Filho W, Figueras A. Adverse drug reactions in an elderly hospitalised population: inappropriate prescription is a leading cause. Drugs Aging 2005; 22: 767–777
Coleman EA, Smith JD, Raha D, et al. Posthospital medication discrepancies: prevalence and contributing factors. Arch Intern Med 2005; 165: 1842–1847
Royal S, Smeaton L, Avery AJ, et al. Interventions in primary care to reduce medication related adverse events and hospital admissions: systematic review and meta-analysis. Qual Saf Health Care 2006; 15: 23–31
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Somers, A., Robays, H., Vander Stichele, R. et al. Contribution of drug related problems to hospital admission in the elderly. J Nutr Health Aging 14, 477–482 (2010). https://doi.org/10.1007/s12603-009-0237-0
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DOI: https://doi.org/10.1007/s12603-009-0237-0