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Carla Task Force on Sarcopenia: Propositions for clinical trials

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JNHA - The Journal of Nutrition, Health and Aging

Abstract

In the presence of an aging population, public health priorities need to evolve. As the populations gets older, the already existing pathologies have become commonplace with specific geriatric clinical syndromes like frailty, mobility disability, or cognitive impairment, among others. Sarcopenia is a good example for which geriatricians, neurologists, physiologists, nutritionists and epidemiologists need to find a consensual definition and diagnostic tool as well as guidelines for the management of clinical trials and possible treatments. The Carla Sarcopenia Task Force, which met in the south of France (Toulouse) for an expert consensus meeting called “Les Entretiens du Carla“, have addressed a series of existing issues to place Sarcopenia into a nosological context: a definition which should be a composite of a change in muscle mass and a change in strength/function depending on either a progressive and chronic wasting process or an acute onset of loss of muscle mass; a recommendation for DXA and the Short Physical Performance Battery as a clinical pragmatic approach of Sarcopenia; a differentiated approach for clinical studies according to prevention or treatment objectives and depending on the sub-groups and target populations; and finally, a summary of therapeutic strategies currently recommended. The aim of “Les Entretiens du Carla”, based on an expert meeting panel, was to address a series of unsolved issues in the field of Sarcopenia by combining the expert opinion with a revision of the existing literature on the topic. Through this report, the reader will appreciate the determination to find conclusions on the various issues and further studies to be developed to determine the best multidisciplinary approach needed.

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Authors and Affiliations

  1. Gérontopôle, INSERM U558, University of Toulouse III, F-31059, Toulouse, France

    G. Abellan Van Kan & B. Vellas

  2. Department of Geriatric Medicine, CHU, Toulouse, F-31059, France

    G. Abellan Van Kan

  3. Public Health, Pierre Fabre Labs, 81106, Castres Cedex, France

    E. André

  4. Centre on Aging and Mobility, University of Zurich, Zurich, Switzerland

    H. A. Bischoff-Ferrari

  5. Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts Boston, USA

    H. A. Bischoff-Ferrari

  6. Human Nutrition Unit, Clinical Nutrition Department, Human Nutrition Research Center of Auvergne, Clermont-Ferrand, France

    Y. Boirie

  7. Department of Geriatrics — Policlinico A. Gemelli, Catholic University of the Sacred Heart, Rome, Italy

    G. Onder

  8. Centro Medicina dell’Invecchiamento, Università Cattolica del Sacro Cuore, L.go Francesco Vito 1, 00168, Roma, Italy

    G. Onder

  9. Department of Aging and Geriatric Research, University of Florida — Institute on Aging, Gainesville, FL, USA

    M. Pahor

  10. Pôle de maladies métaboliques et médecine interne, Angers, France

    Patrick Ritz

  11. Pôle de maladies métaboliques et médecine interne, CHU, 49033, Angers, France

    Patrick Ritz

  12. Service de Médecine Interne et de Gérontologie Clinique, Pavillon Junot, Hôpital La Grave-Casselardit, 170 avenue de Casselardit, 31300, Toulouse, France

    Y. Rolland

  13. INSERM U558, University of Toulouse III, F-31059, Toulouse, France

    Y. Rolland

  14. Instituto de Medicina Molecular, Universidade de Lisboa, Lisboa, Portugal

    C. Sampaio

  15. Pittsburgh Claude D. Pepper Center, P30, AG, 024827, Pittsburgh, USA

    S. Studenski

  16. Department of Health Sciences, Faculty of Earth and Life Sciences, VU University Amsterdam, De Boelelaan 1085, 1081 HV, Amsterdam, the Netherlands

    M. Visser

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  1. G. Abellan Van Kan
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  2. E. André
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Abellan Van Kan, G., André, E., Bischoff-Ferrari, H.A. et al. Carla Task Force on Sarcopenia: Propositions for clinical trials. J Nutr Health Aging 13, 700–707 (2009). https://doi.org/10.1007/s12603-009-0200-0

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