Abstract
Melamine, a nitrogen-rich chemical, has received much attention in recent years owing to a series of highly publicized food safety incidents. These include pet food recalls in North America in 2007 and the deaths of six infants and the illness of some 300,000 more in China in 2008 owing to the adulteration of milk, infant formula, and other milk-derived products. With contamination of human food and animal feed by melamine becoming a serious public health concern owing to its wide dissemination, there is an urgent need to understand why this scandal occurred and its consequences in depth. This review summarizes information relating to the manufacture, uses, occurrence and quantitative analysis of melamine and melamine analogues. Other sections deal with the unfolding of the melamine scandal and its aftermath, the toxicity and carcinogenicity of the compound and its analogues, interim safety measures and risk assessment.
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References
Allen LM, Briggle TV, Pfaffenberger CD (1982) Absorption and excretion of cyanuric acid in long-distance swimmers. Drug Metab Rev 13:499–516
Anon (1983) Carcinogenesis Bioassay of Melamine (CAS NO. 108-78-1) in F344/N rats and B6C3F1 mice (feed study). http://ntp.niehs.nih.gov/ntp/htdocs/LT_rpts/tr245.pdf. Accessed 30th Nov 2009
Anon (2007) Filler in animal feed is open secret in China. http://www.nytimes.com/2007/04/30/business/worldbusiness/30food.html?_r=1&pagewanted%20=%201&hp. Accessed 12th Nov 2009
Anon (2008a) Melamine ‘widespread’ in China’s food chain. http://www.newscientist.com/article/dn14791-melamine-widespread-in-chinese-food-chain.html. Accessed 12th Nov 2009
Anon (2008b) Rush to find extent of NZ melamine contamination. http://www.stuff.co.nz/national/644196. Accessed 12th Nov 2009
Anon (2008c) Spilling the blame for China’s Milk Crisis. http://english.caijing.com.cn/2008-10-10/110019183.html. Accessed 12th Nov 2009
Anon (2008d) U.S. pharmacopeia working to better detect, measure melamine adulteration in food: combating an international public health threat. http://vocuspr.vocus.com/vocuspr30/ViewAttachment.aspx?EID=iWHe7+WVgJ/c0SzvBPWutY0nK/dLYMRUlamavgpUjyw=. Accessed 12th Nov 2009
Anon (2008e) International reaction to the 2008 Chinese milk scandal. http://en.wikipedia.org/wiki/International_Reaction_to_the_2008_Chinese_Milk_Scandal. Accessed 12th Nov 2009
Bingham E, Cohrssen B, Powell CH (2001) Patty’s toxicology, volumes 1–9, 5th edn. Wiley, New York
Bizzari S, Yokose K (2008) Melamine. In: Chemical economics handbook. Menlo Park, CA, SRI Consulting, Inc. http://www.sriconsulting.com/CEH/Public/Reports/673.3000/. Accessed 12th Nov 2009
Bradley D (2008) Melamine scandal widens. http://www.sciencebase.com/science-blog/melamine-scandal-widens.html. Accessed 12th Nov 2009
Brown CA, Jeong KS, Poppenga RH (2007) Outbreaks of renal failure associated with melamine and cyanuric acid in dogs and cats in 2004 and 2007. J Vet Diagn Invest 19:525–531
Buur JL, Baynes RE, Riviere JE (2008) Estimating meat withdrawal times in pigs exposed to melamine contaminated feed using a physiologically based pharmacokinetic model. Regul Toxicol Pharmacol 51:324–331
Chan ZCY, Lai W (2009) Revisiting the melamine contamination event in China: implications for ethics in food technology. Trends Food Sci Technol 20:366–373
Dobson RLM, Motlagh S, Quijano M, Cambron RT, Baker TR, Pullen AM, Regg BT, Bigalow-Kern AS, Vennard T, Fix A, Reimschuessel R, Overmann G, Shan Y, Daston GP (2008) Identification and characterization of toxicity of contaminants in pet food leading to an outbreak of renal toxicity in cats and dogs. Toxicol Sci 106:251–262
Ehling S, Tefera S, Ho IP (2007) High-performance liquid chromatographic method for the simultaneous detection of the adulteration of cereal flours with melamine and related triazine by-products ammeline, ammelide, and cyanuric acid. Food Addit Contam 24:1319–1325
European Food Safety Authority (2008) EFSA assesses possible risks related to melamine in composite foods from China. http://www.efsa.europa.eu/EFSA/efsa_locale-1178620753812_1211902098433.htm. Accessed 12th Nov 2009
Filigenzi MS, Tor ER, Poppenga RH, Aston LA, Puschner B (2007) The determination of melamine in muscle tissue by liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom 21:4027–4032
Food Standards Agency (2008) Melamine contamination of milk and milk products from China. http://www.food.gov.uk/multimedia/pdfs/enforcement/enfe08064update3.pdf. Accessed 12th Nov 2009
Garber EAE (2008) Detection of melamine using commercial enzyme-linked immunosorbent assay technology. J Food Prot 71:590–594
Han C, Wu Y, Zhou Y, Gong Y, Liu C, Wang L, Shen Y (2009) Microwave-assisted extraction of melamine residues from pet food and analysis by ion-exchange LC–DAD. Chromatographia 70:927–931
He L, Liu Y, Lin M, Awika J, Ledoux DR, Li H, Mustapha A (2008) A new approach to measure melamine, cyanuric acid, and melamine cyanurate using surface enhanced Raman spectroscopy coupled with gold nanosubstrates. Sens & Instrumen Food Qual 2:66–71
IARC (1986) IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans, Vol. 39. Some chemicals used in plastics and elastomers, Lyon, pp 333–346
IARC (1999) Monographs on the evaluation of the carcinogenic risk of chemicals to man. World Health Organization, International Agency for Research on Cancer, Geneva, V73
Jutzi K, Cook AM, Hutter R (1982) The degradative pathway of the s-triazine melamine. The steps to ring cleavage. Biochem J 208:679–684
Kim B, Perkins LB, Bushway RJ (2008) Determination of melamine in pet food by enzyme immunoassay, high-performance liquid chromatography with diode array detection, and ultra-performance liquid chromatography with tandem mass spectrometry. J AOAC Int 91:408–413
Lam CW, Lan L, Che X, Tam S, Wong S, Chen Y, Jin J, Tao S, Tang X, Yuen K, Tam PK (2009) Diagnosis and spectrum of melamine-related renal disease: plausible mechanism of stone formation in humans. Clin Chim Acta 402:150–155
Lipschitz WL, Stokey E (1945) The mode of action of three new diuretics: melamine, adenine and formoguanamine. J Pharmacol Exp Ther 83:235–249
Litzau JJ, Mercer GF, Mulligan KJ (2008) GC-MS Screen for the presence of melamine, ammeline, ammelide and cyanuric acid. USFDA Laboratory information bulletin No. 4423
Macartney J (2009) Two executed over tainted milk that killed babies. The London Times, November 25th
Mast RW, Jeffcoat AR, Sadler BM, Kraska RC, Friedman MA (1983) Metabolism, disposition and excretion of [14C] melamine in male Fischer 344 rats. Food Chem Toxicol 21:807–810
Mauer LJ, Chernyshova AA, Hiatt A, Deering A, Davis R (2009) Melamine detection in infant formula powder using near- and mid-infrared spectroscopy. J Agric Food Chem 57:3974–3980
Maxwell GR (2007) Synthetic nitrogen products. In: Kent JA (ed) Kent and Riegel’s handbook of industrial chemistry and biotechnology, 11th edn. Springer, New York, pp 996–1085
Melnick RL, Boorman GA, Haseman JK, Montali RJ, Huff J (1984) Urolithiasis and bladder carcinogenicity of melamine in rodents. Toxicol Appl Pharmacol 72:292–303
Muñiz-Valencia R, Ceballos-Magaña SG, Rosales-Martinez D, Gonzalo-Lumbreras R, Santos-Montes A, Cubedo-Fernandez-Trapiella A, Izquierdo-Hornillos RC (2008) Method development and validation for melamine and its derivatives in rice concentrates by liquid chromatography. Application to animal feed samples. Anal Bioanal Chem 392:523–531
New Zealand Food Safety Authority (2008) New Zealand melamine response update. http://www.nzfsa.govt.nz/publications/media-releases/2008/26-sep-melamine-response-update.htm. Accessed 12th Nov 2009
OECD (1998) Screening information data set for melamine, CAS No. #108-78-1 (http://www.chem.unep.ch/irptc/sids/OECDSIDS/108781.pdf). Accessed 12th Nov 2009
OECD (1999) Screening information data set for isocyanuric acid CAS No 108-80-5. http://www.chem.unep.ch/irptc/sids/OECDSIDS/108805.pdf. Accessed 12th Nov 2009
Patakioutas G, Savvas D, Matakoulis C, Sakellarides T, Albanis T (2007) Application and fate of cyromazine in a closed-cycle hydroponic cultivation of bean (Phaseolus vulgaris L.). J Agric Food Chem 55:9928–9935
Perdigão LMA, Champness NR, Beton PH (2006) Surface self-assembly of the cyanuric acid–melamine hydrogen bonded network. Chem Commun 5:538–540
Puschner B, Poppenga RH, Lowenstine LJ, Filigenzi MS, Pesavento PA (2007) Assessment of melamine and cyanuric acid toxicity in cats. J Vet Diagn Invest 19:616–624
Shelton DR, Karns JS, McCarty GW, Durham DR (1997) Metabolism of melamine by Klebsiella Terragena. Appl Environ Microbiol 63(7):2832–2835
Turnipseed S, Casey C, Nochetto C, Heller DN (2008) Determination of melamine and cyanuric acid residues in infant formula using LC-MS/MS. USFDA Laboratory Information. October 2008 Bulletin No. 4421
US FDA (2007) Interim melamine and analogues safety/risk assessment. http://www.fda.gov/ScienceResearch/SpecialTopics/PeerReviewofScientificInformationandAssessments/ucm155012.htm. Accessed 12th Nov 2009
US FDA (2008) Interim safety and risk assessment of melamine and its analogues in food for humans. www.cfsan.fda. gov/∼dms/melamra3.html. Accessed 12th Nov 2009
US FDA (2009) Melamine contamination in China. http://www.fda.gov/ohrms/DOCKETS/ac/08/briefing/2008-4386b3.pdf. Accessed 12th Nov 2009
Vail T, Jones PR, Sparkman O, David D (2007) Rapid and unambiguous identification of melamine in contaminated pet food based on mass spectrometry with four degrees of confirmation. J Anal Toxicol 31(6):304–312
Varelis P, Jeskelis R (2008) Preparation of [13C3]-melamine and [13C3]-cyanuric acid and their application to the analysis of melamine and cyanuric acid in meat and pet food using liquid chromatography-tandem mass spectrometry. Food Addit Contam 25:1208–1215
WHO (2004) Sodium dichloroisocyanurate. In: Safety evaluation of certain food additives and contaminants. Prepared by the sixty-first meeting of the Joint FAO/WHO Expert Committee on Food Additives. Geneva, World Health Organization (WHO Food Additives Series, No. 52; http://whqlibdoc.who.int/publications/2004/924166052X.pdf. Accessed 12th Nov 2009
WHO (2008a) Melamine-contaminated powdered infant formula in China. http://www.who.int/csr/don/2008_09_19/en/index.html. Accessed 12th Nov 2009
WHO (2008b) Experts set tolerable level for melamine intake. http://www.who.int/mediacentre/news/releases/2008/pr48/en/index.html. Accessed 30th Nov 2009
WHO (2009) Toxicological and health aspects of melamine and cyanuric acid. http://www.who.int/foodsafety/publications/chem/Melamine_report09.pdf. Accessed 30th Nov 2009
Wong G (2008) China’s dairy farmers fret as milk scandal grows. Associated Press. http://www.encyclopedia.com/doc/1A1-D93BGRF80.html. Accessed 12th Nov 2009
Wong S (2009) China death sentences may protect exports after milk scandal. http://www.bloomberg.com/apps/news?pid=20601080&sid=awClBNXRxuj4&refer=asia. Accessed 12th Nov 2009
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An erratum to this article can be found at http://dx.doi.org/10.1007/s12571-010-0057-4
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Sharma, K., Paradakar, M. The melamine adulteration scandal. Food Sec. 2, 97–107 (2010). https://doi.org/10.1007/s12571-009-0048-5
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DOI: https://doi.org/10.1007/s12571-009-0048-5