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A case of primary ciliary dyskinesia treated with ICSI using testicular spermatozoa: case report and a review of the literature

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Reproductive Medicine and Biology

Abstract

Purpose

To investigate whether or not intracytoplasmic sperm injection (ICSI) using spermatozoa extracted from testis (TESE-ICSI) is a more effective treatment than ICSI with ejaculated spermatozoa (EJ-ICSI) for primary ciliary dyskinesia (PCD).

Methods

We reported a case of PCD in which we performed TESE-ICSI after repeated failure of EJ-ICSI. Together with data from previous case reports, we compared the fertilization rate and pregnancy outcome of TESE-ICSI and EJ-ICSI.

Results

In our case, TESE-ICSI improved the morphology of spermatozoa and fertilization rate. However, the outcome was only a biochemical pregnancy. According to the analysis combined with previous reports, there was no difference in the fertilization rate and pregnancy outcome parameters between TESE-ICSI and EJ-ICSI.

Conclusions

TESE-ICSI for PCD may improve the fertilization rate compared to EJ-ICSI. However, it does not necessarily improve the pregnancy outcome for a patient with primary ciliary dyskinesia.

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Conflict of interest

All of the authors declare that they have no conflict of interest.

Human Rights statement and informed consent

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1964 and its later amendments. Informed consent was obtained from the patients for being included in the study.

Animal studies

This article does not contain any studies with animal subjects performed by any of authors.

Author information

Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Ibaraki, Tsukuba, Japan

    Akiko Kawasaki & Hiroyuki Yoshikawa

  2. Department of Obstetrics and Gynecology, Tsukuba-Gakuen Hospital, 2573-1 Kamiyokoba, Ibaraki, Tsukuba, Japan

    Akiko Kawasaki, Hajime Okamoto, Atsushi Wada, Yoko Ainoya, Naoki Kita, Tetsuro Maeyama & Naoko Edamoto

  3. Department of Urology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Ibaraki, Tsukuba, Japan

    Hiroyuki Nishiyama & Akira Joraku

  4. Department of Urology, Tsukuba-Gakuen Hospital, 2573-1 Kamiyokoba, Ibaraki, Tsukuba, Japan

    Sadamu Tsukamoto & Natsui Waku

Authors
  1. Akiko Kawasaki
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  2. Hajime Okamoto
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  3. Atsushi Wada
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  4. Yoko Ainoya
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  5. Naoki Kita
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  6. Tetsuro Maeyama
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  7. Naoko Edamoto
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  8. Hiroyuki Nishiyama
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  9. Sadamu Tsukamoto
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  10. Akira Joraku
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  11. Natsui Waku
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  12. Hiroyuki Yoshikawa
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Corresponding author

Correspondence to Akiko Kawasaki.

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Cite this article

Kawasaki, A., Okamoto, H., Wada, A. et al. A case of primary ciliary dyskinesia treated with ICSI using testicular spermatozoa: case report and a review of the literature. Reprod Med Biol 14, 195–200 (2015). https://doi.org/10.1007/s12522-015-0210-z

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  • DOI: https://doi.org/10.1007/s12522-015-0210-z

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