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Abnormal lysine acetylation with postovulatory oocyte aging

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Reproductive Medicine and Biology

Abstract

Background

A postovulatory mammalian oocyte decreases developmental potential with in vivo aging in the oviduct or in vitro aging in the culture dish. The mechanism underlying oocyte aging still largely remains an enigma. Accumulating data suggest that the epigenetic alterations such as histone acetylation are also associated with postovulatory aging.

Objective

To perform a review evaluating a new aspect of oocyte aging in terms of the epigenetic alterations focusing on lysine acetylation.

Methods

In addition to a search of the literature in Pubmed, we introduced our recent published data.

Results

Histone acetylation in the mouse oocyte increases during aging, potentially impacting gene regulation in the subsequent embryonic development. Oocyte aging results in increased acetylation of alpha-tubulin, a non-histone protein, and nicotinamide, an inhibitor of class III HDAC, partially prevents some of oocyte aging phenotypes.

Conclusion

Abnormal regulation of protein acetylation itself is suggested in oocyte aging and could contribute to the aging phenotypes.

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Acknowledgments

We acknowledge discussions with T. Castranio. We are grateful to all the laboratory members for their comments and help. Part of the work cited in this paper was supported by the PRESTO (Precursory Research for Embryonic Science and Technology) program of the Japan Science and Technology Agency and a Grant-in-Aid for Scientific Research (KAKENHI) from the Japan Society for the Promotion of Science (grant number 23580416, to SK).

Conflict of interest

The author declares that they have no conflict of interest.

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Authors and Affiliations

  1. Division of Biological Science, Graduate School of Biology-Oriented Science and Technology, Kinki University, Kinokawa, Wakayama, 649-6493, Japan

    Ah Reum Lee, Le Thanh Ha, Satoshi Kishigami & Yoshihiko Hosoi

  2. PRESTO, Japan Science and Technology Agency, Kawaguchi, Saitama, 332-0012, Japan

    Satoshi Kishigami

Authors
  1. Ah Reum Lee
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  2. Le Thanh Ha
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  3. Satoshi Kishigami
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  4. Yoshihiko Hosoi
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Corresponding author

Correspondence to Satoshi Kishigami.

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Cite this article

Lee, A.R., Thanh Ha, L., Kishigami, S. et al. Abnormal lysine acetylation with postovulatory oocyte aging. Reprod Med Biol 13, 81–86 (2014). https://doi.org/10.1007/s12522-013-0172-y

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  • DOI: https://doi.org/10.1007/s12522-013-0172-y

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