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Assessment of cardiac function in infants with transposition of the great arteries after surgery: comparison of two methods

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Abstract

Background

Assessment of cardiac function is crucial in pediatric patients undergoing cardiovascular surgery, monitoring cardiac output and changing hemodynamic conditions during surgery accordingly is important to improve post-surgical outcome. We aimed to measure cardiac index (CI) and maximal rate of the increase of left ventricular pressure dp/dt(max) with the pressure recording analytic method (PRAM, MostCare®) and compared it with transthoracic echocardiographic cardiac index estimation in infants with transposition of the great arteries (TGA) undergoing surgical correction.

Methods

We enrolled 74 infants with TGA consecutively into this study. CI and dp/dt(max) were measured with PRAM and echocardiography at 0, 4, 8, 12, 24 and 48 h postoperatively. Blood brain natriuretic peptide (BNP) and blood lactate (Lac) were measured at baseline and after operation.

Results

The median age at surgery was 13 days (range 1–25 days) with an average weight of 3.24 kg (range 2.31–4.17 kg). CI estimated by PRAM was 1.11 ± 0.12 L/min/m2 (range 0.69–1.36) and by Doppler echocardiography was 1.13 ± 0.13 L/min/m2 (range 0.76–1.40). dp/dt(max) estimated by PRAM was 1.31 ± 0.03 mmHg/s (range 1.23–1.43) and by Doppler echocardiography was 1.31 ± 0.04 L/min/m2 (range 1.25–1.47). CI (r = 0.817, P < 0.001) and dp/dt(max) (r = 0.794, P < 0.001) measured by two methods were highly correlated with a linear relation. Blood BNP and lactate increased to the highest level at 8–12 h post-operatively.

Conclusions

In the early post-operative period, PRAM provides reliable estimates of cardiac index and dp/dt(max) value compared with echocardiographic measurements. PRAM through mostcare® is a reliable continuous monitoring method for peri-operative management in children with congenital heart disease.

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Acknowledgements

We thank everybody of this study group members. We also thank the physicians and nurses of HBCH and OPBG-units for their dedicated work and the patients and their families for their cooperation.

Funding

No funding was secured for this study.

Author information

Authors and Affiliations

  1. Cardiac Surgery Department, Hebei Province Children’s Hospital, No. 133, Jianhua South Street, Shijiazhuang, 050031, China

    Fan Yang & Jian-Ming Wang

  2. Pediatric Cardiology Center of Ospedale Pediatrico Bambino Gesù, Piazza S. Onofrio 4, 00165, Rome, Italy

    Roberta Iacobelli & Fiore Salvatore Iorio

Authors
  1. Fan Yang
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  2. Roberta Iacobelli
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  3. Jian-Ming Wang
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  4. Fiore Salvatore Iorio
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Contributions

YF designed the study, collected cases, analyzed the data and wrote the paper. RI designed the study, wrote part of the paper and corrected the original paper. WJM and FSI contributed to offer the suitable cases and related equipments. All authors contributed to the critical revision and final approval of the manuscript.

Corresponding author

Correspondence to Fiore Salvatore Iorio.

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Ethical approval

The study protocol was approved by Local Ethics Committee of Hebei Province Children’s Hospital.

Conflict of interest

No financial or nonfinancial benefits have been received or will be received from any party related directly or indirectly to the subject of this article.

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Yang, F., Iacobelli, R., Wang, JM. et al. Assessment of cardiac function in infants with transposition of the great arteries after surgery: comparison of two methods. World J Pediatr 14, 373–377 (2018). https://doi.org/10.1007/s12519-018-0178-y

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  • DOI: https://doi.org/10.1007/s12519-018-0178-y

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