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Characterization of myocardial oxidative metabolism and myocardial external efficiency in high-risk alcohol cardiotoxicity and alcoholic cardiomyopathy via dynamic 11C-Acetate positron emission tomography

  • Original Article
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Journal of Nuclear Cardiology Aims and scope

Abstract

Introduction

The purpose of this study was to evaluate subjects with high-risk alcohol cardiotoxicity and patients with alcoholic cardiomyopathy (ACM) via dynamic 11C-Acetate positron emission tomography (PET) imaging as a myocardial oxidative metabolic probe.

Methods and Results

We recruited 37 subjects with chronic alcohol consumption [18 with moderate consumption (MC), 19 with heavy consumption (HC)], 5 ACM patients, and 12 healthy controls to receive dynamic 11C-Acetate PET scans. PET imaging data were analyzed to calculate kinetic parameters (e.g., Kmono, K1 and k2) based on the mono-exponential and one-tissue compartmental models. Myocardial oxygen consumption (MVO2) and myocardial external efficiency (MEE) were then derived from these kinetic parameters. MVO2 was significantly lowered in the HC group and in ACM patients (0.121± 0.018 and 0.111 ± 0.017 mL·g−1·min−1, respectively) compared with those in healthy controls and MC subjects (0.144 ± 0.023 and 0.146 ± 0.027 mL·g−1·min−1, respectively; P < .01). MEE was significantly reduced in ACM patients (13.0% ± 4.3%) compared with those of healthy controls (22.4% ± 4.6%, P < .01), MC subjects (20.1% ± 4.5%, P < .05), and HC subjects (22.3% ± 4.5%, P < .001).

Conclusion

Functional assessment via dynamic 11C-Acetate PET imaging may represent a clinically feasible probe for identifying cohorts with high-risk cardiotoxicity due to addictive alcohol consumption and ACM.

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Abbreviations

ACM:

Alcoholic cardiomyopathy

CT:

Computed tomography

EW:

Effective external work

HC:

Heavy consumption

MBF:

Myocardial blood flow

MC:

Moderate consumption

MEE:

Myocardial external efficiency

MVO2 :

Myocardial oxygen consumption

PET:

Positron emission tomography

WMI:

Work metabolic index

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Acknowledgments

This work was sponsored in part by the National Natural Science Foundation of China (Grant Number: 81571713) and the CAMS Innovation Fund for Medical Sciences (Grant Numbers: 2016-I2M-4-003, 2017-I2M-3-001, 2018-I2M-3-001).

Disclosure

All authors declare that they have no conflicts of interest.

Author information

Author notes

  1. Ximin Shi and Shuai Liu contributed equally to this work and should be considered co-first authors.

Authors and Affiliations

  1. Department of Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Beijing, 100730, China

    Ximin Shi MD, Jie Ding MD, Yonghong Dang PhD, Haiqun Xing MD, Fang Li MD & Li Huo MD

  2. Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

    Xue Lin MD & Ligang Fang MD

  3. Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University School of Medicine, Beijing, China

    Shuai Liu PhD & Xihai Zhao PhD

  4. Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland

    Chunlei Han PhD & Juhani Knuuti MD

  5. GE Healthcare China, Beijing, China

    Chengyan Dong PhD

  6. Nuclear Science and Engineering Institute, University of Missouri-Columbia, Columbia, MO, USA

    Bailing Hsu PhD

  7. Department of Nuclear Medicine, Fuwai Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China

    Wei Fang MD

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  1. Ximin Shi MD
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  12. Wei Fang MD
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  13. Fang Li MD
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  15. Juhani Knuuti MD
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Corresponding author

Correspondence to Li Huo MD.

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Shi, X., Liu, S., Lin, X. et al. Characterization of myocardial oxidative metabolism and myocardial external efficiency in high-risk alcohol cardiotoxicity and alcoholic cardiomyopathy via dynamic 11C-Acetate positron emission tomography. J. Nucl. Cardiol. 29, 278–288 (2022). https://doi.org/10.1007/s12350-020-02214-0

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