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The influence of anthropometric and basic circulatory variables on count rate in cadmium-zinc-telluride SPECT gated radionuclide angiography

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Journal of Nuclear Cardiology Aims and scope

Abstract

Aim

To determine the influence of weight, height, gender, age, heart rate, and blood pressure on count rate in cadmium-zinc-telluride single-photon emission computed tomography (CZT SPECT) gated radionuclide angiography.

Method

A total of 1,065 eligible patients referred for routine assessment of left ventricular ejection fraction were registered from August 2015 to November 2016. Data were recorded on heart rate, systolic and diastolic blood pressure, age, gender, height, weight, and count rate. All radionuclide angiographies were performed on a dedicated cardiac CZT SPECT camera, GE Discovery 530c. A dose of 550 MBq 99mTc-labeled human serum albumin was administered intravenously to each patient.

Results

Count rate varied from 1.2 to 8.9 counts per second. All test variables were significantly associated with count rate. From the preliminary analysis, weight appeared as the main contributing factor for explaining the variations in count rate with and R2 of 0.68.

A model consisting of weight, height, gender, and age explains 75% of the variance in count rate.

Conclusion

Patient height, weight, gender, and age have significant impact on count rate when performing CZT radionuclide angiography and may subsequently be used for individualized planning of tracer dosage.

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Abbreviations

CZT:

Cadmium-zinc-telluride

LVEF:

Left ventricular ejection fraction

ALARA:

As low as reasonably achievable

MPI:

Myocardial perfusion imaging

ARSAC:

The Administration of Radioactive Substances Advisory Committee

SPECT:

Single-photon emission computed tomography

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Authors and Affiliations

  1. Department of Clinical Physiology and Nuclear Medicine, Herlev Hospital, University of Copenhagen, Herlev, Denmark

    Julie Rydberg MD, Jannick Andersen Cand.merc., Christian Haarmark MD, PhD & Bo Zerahn MD

Authors
  1. Julie Rydberg MD
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  2. Jannick Andersen Cand.merc.
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  3. Christian Haarmark MD, PhD
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  4. Bo Zerahn MD
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Correspondence to Julie Rydberg MD.

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Rydberg, J., Andersen, J., Haarmark, C. et al. The influence of anthropometric and basic circulatory variables on count rate in cadmium-zinc-telluride SPECT gated radionuclide angiography. J. Nucl. Cardiol. 26, 1974–1980 (2019). https://doi.org/10.1007/s12350-018-1402-9

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  • DOI: https://doi.org/10.1007/s12350-018-1402-9

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