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For dynamic cardiac PET of quantifying myocardial blood flow (MBF), patient motion is a major factor that affects the ROI definition and absolute quantification accuracy. In a recent study, an 82rubidium (82Rb)-dynamic-tailored motion-correction framework has been proposed to address the voluntary body motion for all the dynamic frames, including both early and late phases.1 This approach brings us one step closer to the practical and full motion correction for dynamic cardiac PET studies. In this editorial, we discussed the current status and limitations of motion-correction methods for dynamic cardiac PET, including the recent publication at JNC, and also pointed out the remaining challenges for future developments.
PET myocardial perfusion imaging has been shown to improve the detection accuracy of coronary artery disease as compared to other non-invasive imaging modalities.2 Many investigators, in the past two decades, have established methods for absolute quantification of MBF and myocardial flow reserve (MFR)3 using dynamic PET, which is superior in diagnostic and prognostic value as compared to the conventional relative myocardial perfusion imaging.4
A prerequisite of accurate quantification in dynamic PET requires appropriate corrections5 to the original dynamic frame data. In additional to corrections for physical factors such as attenuation, scatter, randoms, and normalization, physiological factors such as patient motion also require correction. Patient motion in cardiac imaging typically includes respiratory motion, cardiac motion, and voluntary body motion. Such motions can cause inaccurate tracer distribution estimation, as well as artifacts introduced by the mismatch between PET and CT-based attenuation map.6 Comparing to more periodic respiratory motion and cardiac motion, the timing for voluntary body motion is typically unpredictable, thus its impact on the MBF and MFR quantifications can be complicated.7
Methods for respiratory motion8 and cardiac motion management9 have been proposed in the past. The body motion correction has also been studied for several PET applications, especially for brain studies.10 However, the correction of body motion for 82Rb cardiac dynamic PET imaging still remains highly challenging mainly due to the following two reasons. First, the rapid tracer kinetics of 82Rb leads to substantial tracer distribution change in the dynamic images over time. Such spatial variations can lead to inaccurate motion estimation, where image registration is typically used, between dynamic frame images. The accuracy of image registration usually relies on the similarity between the two to-be-registered images. However, rapid tracer kinetics may result in one frame image very different from the other, therefore leading to inaccurate registration and subsequently inaccurate motion estimation. This might be the reason that currently available software in the clinic typically are only applicable to correct body motion in the later uptake phases11 but not early dynamic phases. Second, it remains challenging to detect body motion, where exact motion timing during the PET scan is hard to predict. The most commonly used frame-based registration approach can only correct motions between pre-defined dynamic frames, but cannot detect intra-frame motion, which is defined as the motion within a dynamic frame. For motion detection at a high temporal resolution, an external motion tracking system can be used.12 However, such tracking systems typically require extra setup time. Therefore, to facilitate clinical translation of body motion correction, data-driven motion detection methods without the need of external devices are preferred.
The work by Lee et al1 published in this issue of JNC attempted to address some of the challenges described above. The authors established a body motion-correction framework for dynamic 82Rb cardiac PET. With extension from their previous studies,13,14 the current study addressed the needs of automated motion correction for the entire dynamic cardiac study, including both the late phase and the early blood pool phase with rapidly changing tracer kinetics. In this study, 225 patients underwent dynamic rest/stress 82Rb PET imaging using a Siemens Biograph mCT PET/CT scanner, where pharmacological stress was performed with regadenoson. A 30-frame dynamic reconstruction, from 20 seconds since injection through 7 minutes, was performed using 3D-OSEM algorithm with point-spread-function and time-of-flight modeling. The investigators, without the ground truth, assumed good correlation in MBF/MFR with manual motion-correction results to be a measure of success. The strength of this premise relies on their previous studies,13 based on the same 225 patients cohort, that manual motion correction was considered as the gold standard when it was performed by a clinician for every dynamic frame. In Ref. 13, Lee et al found that translational body motion was most prevalent in the blood phase, resulting in the strongest impact on the right coronary artery region. Although only translational rigid motion was considered, the current work established an automated correction framework for cardiac dynamic PET especially including the blood pool phase, making it the only correction algorithm that applies to the entire dynamic sequence to the best of our knowledge.
In a dynamic PET study, after injection, 82Rb in sequence enters right ventricle blood pool (RVBP), left ventricle blood pool (LVBP), and then myocardium tissue. Therefore, the tracer distribution in the early frames is very different from later frames. Thus, motion estimation between early and late frames can be recast as a multi-model registration problem, for which mutual information is typically used as the similarity metric. However, there has been no such application for the entire dynamic cardiac PET frames. The current study by Lee et al,1 instead, proposed to use a normalized gradient-field-based similarity metric, defined as the first order derivatives of a smoothed PET image, in the motion estimation process. With the assumption that “two image volumes were considered similar if the normalized gradient directions were aligned at a given position”,1 each dynamic image frame was rigidly aligned to match a fixed later phase summed frame, i.e., 120 to 400 seconds post-injection, to achieve motion correction. Incorporated with RVBP and LVBP regions generated by a blood pool-tissue isolation algorithm, this new similarity metric was tailored in this study to facilitate motion correction for the entire dynamic study.
In terms of motion-correction results, excellent linear agreement was found in MBF between the proposed automated motion-correction algorithm and manual motion correction. Effective reduction of the variability of MBF quantification was also achieved by using the automated algorithm. The proposed algorithm yielded consistent translational motion estimation with the manual motion-correction results for the tissue phase, albeit the motion was relatively small with less than 1 mm on average. The same agreement was not found in the blood phase, where the mean difference was found to be up to 5 mm, mainly due to the fact that the clinician could not confidently estimate the motion for the RV blood phase in the manual approach. Nevertheless, the significance of the current study shall not only be judged by its correction effectiveness, but also by its innovation of the automated motion-correction framework, especially the motion estimation step using gradient-field-based similarity metric and its application to the entire dynamic study.
Of note, the overall BM magnitude reported in the current study was relatively small, even for the blood phase. Motion magnitude was found larger in the stress studies than that in the rest studies.1 In another study, the incidence and magnitude of motion reported in Ref. 7 were much larger than those reported in the current study. In Ref. 7, 24% of the cases showed 0.5 ± 0.1 cm body motion, 38% showed 1.0 ± 0.3 cm, and no difference was found between the rest and stress studies. In addition, in Ref. 7, substantial body motion maintained constant in frequency from 2 to 8 minutes while in the current study, minimal motion was found after 2 minutes post-injection. Both studies included over 200 patients thus the consideration of statistical significance is excellent. The motion magnitude and timing difference in the stress study could be explained by the use of a different vasodilator.15 In Ref. 15, patients stressed using 20 seconds-injected regadenoson was found to have a significantly lower amount of motion as compared to those with adenosine infused over several minutes. The current study1 used regadenoson while7 used dipyridamole. However, the reason for motion magnitude difference in the rest studies between the two publications is not clear. Note that all motion estimations in the above studies were based on human observation of pre-defined dynamic frames of reconstructions, which could be subjective and observer-dependent. In addition, the motion within each of the dynamic frames, especially for later frames with longer durations, may be overlooked depending on the motion degree and timing. Therefore, if motion detection in high temporal resolution is desired to address the intra-frame motion, there is still a need for external motion tracking system.12 However, such systems have clear limitations of being complicated and time consuming to set up. Therefore, a data-driven method, which directly extracts motion signal from PET raw data, can be more clinically appealing instead. Data-driven methods have been proposed by many groups for respiratory16 and cardiac motion tracking17 while a reliable way of detecting body motion in high temporal resolution in order to correct intra-frame motion, especially in context of rapid tracer distribution change, is yet to be developed.
Lastly, despite the innovation and encouraging results from Ref. 1 and other studies, motion correction for dynamic cardiac PET can be further improved. Several examples of such improvement in the future can include, but are not limited to, the following directions: (1) incorporation of respiratory and cardiac motion management for dynamic PET is needed.18 The impact from respiratory motion may vary depending on the frame duration, especially for those short frames, e.g., less than 10 seconds, which is on the similar order of a respiratory cycle. In addition, respiratory pattern change, in particular due to vasodilators in the early frames of stress studies, could also have significant impact on difference dynamic frames.19 Cardiac motion correction for PET itself is still a very challenging task given the high non-rigidness of the cardiac movement, where effective approach for cardiac motion correction heavily relies on accurate motion estimation or additional information from other modalities such as MR.18 (2) Most studies only considered translational motion for cardiac PET, whereas body motion may come with rotation and even non-rigid motion for cardiac imaging. Correction of motion in a non-rigid manner may be needed. (3) The motion between attenuation map and PET can lead to large errors in MBF,7 which needs to be corrected. While some manual alignment tools are available in the clinic, automatic approach to generate aligned attenuation map for all dynamic frames is desirable. In particular, recent advances in joint reconstruction of emission activity and registration of attenuation map using TOF data provide a highly promising tool to generate perfectly aligned attenuation maps.20 (4) Intra-frame motion remains very challenging to correct. To achieve a full correction of intra-frame motion, as discussed above, a data-driven motion detection algorithm is needed, especially for dynamic cardiac PET.
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This work is supported by NIH grant R01CA224140.
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Yihuan Lu and Chi Liu have nothing to disclose related to this work.
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Lu, Y., Liu, C. Patient motion correction for dynamic cardiac PET: Current status and challenges. J. Nucl. Cardiol. 27, 1999–2002 (2020). https://doi.org/10.1007/s12350-018-01513-x
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DOI: https://doi.org/10.1007/s12350-018-01513-x