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The validity of multi-center common normal database for identifying myocardial ischemia: Japanese Society of Nuclear Medicine working group database

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Abstract

Purpose

The Japanese Society of Nuclear Medicine (JSNM) working group has created a myocardial perfusion imaging database applicable to standard acquisition protocol. The aim of this study is to validate the diagnostic accuracy of the common normal database compared with the expert interpretation of each institute.

Methods

Five institutions participated in this study and used different acquisition settings which included 360°/180° rotation, camera configuration and camera orbits. The software and its version used in each institution also varied. The working group database was applied to detect the culprit coronary territory from a total of 166 patients with coronary artery disease (CAD) and 145 patients with low-likelihood of CAD.

Results

When summed stress score ≥4 was defined as significant abnormality, overall sensitivity, specificity and accuracy of patient-based analysis were 77, 72 and 75%, respectively, based on quantitative analysis using the common database, whereas those by institutional visual expert reading were 72, 79 and 75%, respectively.

Conclusion

The common database, which was created by a multi-center working group and separated between male/female with 180/360° acquisitions, demonstrated comparable diagnostic accuracy to expert interpretation by each institute, and it may be applicable to multi-center studies.

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Acknowledgments

This work was performed as part of the JSNM working group activity and supported by Grants-in-Aid for Scientific Research in Japan (PI: Kenichi Nakajima). We also thank GE Yokogawa Medical Systems for providing a workstation for data processing. The research version of QPS software was supplied by Drs Germano and Slomka (Cedars Sinai Medical Center, USA).

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Author notes

  1. Jun Hashimoto

    Present address: Department of Radiology, Tokai University School of Medicine, Isehara, Japan

Authors and Affiliations

  1. Department of Nuclear Medicine, Kanazawa University Hospital, 13-1 Takara-machi, Kanazawa, 920-8641, Japan

    Kenichi Nakajima, Shinro Matsuo & Junichi Taki

  2. Department of Radiology, Kanazawa Cardiovascular Hospital, Kanazawa, Japan

    Masaya Kawano

  3. Department of Cardiology, Nihon University Surugadai Hospital, Tokyo, Japan

    Naoya Matsumoto

  4. Department of Radiology, Keio University, Tokyo, Japan

    Jun Hashimoto

  5. Department of Molecular Imaging, Hokkaido University Graduate School of Medicine, Sapporo, Japan

    Keiichiro Yoshinaga

  6. Department of Biotracer Medicine, Kanazawa University, Kanazawa, Japan

    Koichi Okuda

Authors
  1. Kenichi Nakajima
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  2. Shinro Matsuo
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  3. Masaya Kawano
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  4. Naoya Matsumoto
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  5. Jun Hashimoto
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  6. Keiichiro Yoshinaga
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  7. Junichi Taki
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  8. Koichi Okuda
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Corresponding author

Correspondence to Kenichi Nakajima.

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Nakajima, K., Matsuo, S., Kawano, M. et al. The validity of multi-center common normal database for identifying myocardial ischemia: Japanese Society of Nuclear Medicine working group database. Ann Nucl Med 24, 99–105 (2010). https://doi.org/10.1007/s12149-009-0331-8

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  • DOI: https://doi.org/10.1007/s12149-009-0331-8

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