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Accurate analysis and visualization of cardiac 11C-PIB uptake in amyloidosis with semiautomatic software

  • Original Article
  • Published:
Journal of Nuclear Cardiology Aims and scope

Abstract

Background

11C-PIB PET is a promising non-invasive diagnostic tool for cardiac amyloidosis. Semiautomatic analysis of PET data is now available but it is not known how accurate these methods are for amyloid imaging. The aim of this study was to evaluate the feasibility of one semiautomatic software tool for analysis and visualization of 11C-PIB left ventricular retention index (RI) in cardiac amyloidosis.

Methods and results

Patients with systemic amyloidosis and cardiac involvement (n = 10) and healthy controls (n = 5) were investigated with dynamic 11C-PIB PET. Two observers analyzed the PET studies with semiautomatic software to calculate the left ventricular RI of 11C-PIB and to create parametric images. The mean RI at 15-25 min from the semiautomatic analysis was compared with RI based on manual analysis and showed comparable values (0.056 vs 0.054 min−1 for amyloidosis patients and 0.024 vs 0.025 min−1 in healthy controls; P = .78) and the correlation was excellent (r = 0.98). Inter-reader reproducibility also was excellent (intraclass correlation coefficient, ICC > 0.98). Parametric polarmaps and histograms made visual separation of amyloidosis patients and healthy controls fast and simple.

Conclusion

Accurate semiautomatic analysis of cardiac 11C-PIB RI in amyloidosis patients is feasible. Parametric polarmaps and histograms make visual interpretation fast and simple.

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Abbreviations

MRI:

Magnetic resonance imaging

PET:

Positron emission tomography

PIB:

Pittburg compound B

AL:

Immunoglobulin light-chain amyloidosis

ATTR:

Transthyretin-realated amyloidosis

ROI:

Region of interest

VOI:

Volume of interest

FUR:

Factional uptake rate

RI:

Retention index

CT:

Computed tomography

MBq:

Megabequerel

ICC:

Intraclass correlation coefficient

SD:

Standard deviation

SUV:

Standardized uptake value

TBR:

Target to background ratio

References

  1. Merlini G, Bellotti V. Molecular mechanisms of amyloidosis. N Engl J Med 2003;349:583-96 Epub 2003/08/09.

    Article  CAS  PubMed  Google Scholar 

  2. Falk RH, Dubrey SW. Amyloid heart disease. Prog Cardiovasc Dis 2010;52:347-61 Epub 2010/01/30.

    Article  PubMed  Google Scholar 

  3. Aprile C, Marinone G, Saponaro R, Bonino C, Merlini G. Cardiac and pleuropulmonary AL amyloid imaging with technetium-99 m labelled aprotinin. Eur J Nucl Med 1995;22:1393-401 Epub 1995/12/01.

    Article  CAS  PubMed  Google Scholar 

  4. Bokhari S, Shahzad R, Castano A, Maurer MS. Nuclear imaging modalities for cardiac amyloidosis. J Nucl Cardiol 2014;21:175-84 Epub 2013/10/29.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Glaudemans AW, Slart RH, Zeebregts CJ, Veltman NC, Tio RA, Hazenberg BP, et al. Nuclear imaging in cardiac amyloidosis. Eur J Nucl Med Mol Imaging 2009;36:702-14 Epub 2009/01/22.

    Article  CAS  PubMed  Google Scholar 

  6. Han S, Chong V, Murray T, McDonagh T, Hunter J, Poon FW, et al. Preliminary experience of 99mTc-Aprotinin scintigraphy in amyloidosis. Eur J Haematol 2007;79:494-500 Epub 2007/11/07.

    Article  PubMed  Google Scholar 

  7. Hawkins PN. Serum amyloid P component scintigraphy for diagnosis and monitoring amyloidosis. Curr Opin Nephrol Hypertens 2002;11:649-55 Epub 2002/10/24.

    Article  PubMed  Google Scholar 

  8. Hazenberg BP, van Rijswijk MH, Piers DA, Lub-de Hooge MN, Vellenga E, Haagsma EB, et al. Diagnostic performance of 123I-labeled serum amyloid P component scintigraphy in patients with amyloidosis. Am J Med 2006;119:355 e15-24 Epub 2006/03/28.

    Article  PubMed  Google Scholar 

  9. Hongo M, Urushibata K, Kai R, Takahashi W, Koizumi T, Uchikawa S, et al. Iodine-123 metaiodobenzylguanidine scintigraphic analysis of myocardial sympathetic innervation in patients with AL (primary) amyloidosis. Am Heart J 2002;144:122-9 Epub 2002/07/03.

    Article  CAS  PubMed  Google Scholar 

  10. Liu D, Niemann M, Hu K, Herrmann S, Stork S, Knop S, et al. Echocardiographic evaluation of systolic and diastolic function in patients with cardiac amyloidosis. Am J Cardiol 2011;108:591-8 Epub 2011/08/03.

    Article  PubMed  Google Scholar 

  11. Rapezzi C, Quarta CC, Guidalotti PL, Longhi S, Pettinato C, Leone O, et al. Usefulness and limitations of 99mTc-3,3-diphosphono-1,2-propanodicarboxylic acid scintigraphy in the aetiological diagnosis of amyloidotic cardiomyopathy. Eur J Nucl Med Mol Imaging 2011;38:470-8 Epub 2010/11/12.

    Article  PubMed  Google Scholar 

  12. Selvanayagam JB, Hawkins PN, Paul B, Myerson SG, Neubauer S. Evaluation and management of the cardiac amyloidosis. J Am Coll Cardiol 2007;50:2101-10 Epub 2007/11/27.

    Article  CAS  PubMed  Google Scholar 

  13. Syed IS, Glockner JF, Feng D, Araoz PA, Martinez MW, Edwards WD, et al. Role of cardiac magnetic resonance imaging in the detection of cardiac amyloidosis. JACC Cardiovasc Imaging 2010;3:155-64 Epub 2010/02/18.

    Article  PubMed  Google Scholar 

  14. Wall JS, Kennel SJ, Stuckey AC, Long MJ, Townsend DW, Smith GT, et al. Radioimmunodetection of amyloid deposits in patients with AL amyloidosis. Blood 2010;116:2241-4 Epub 2010/06/05.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Mongeon FP, Jerosch-Herold M, Coelho-Filho OR, Blankstein R, Falk RH, Kwong RY. Quantification of extracellular matrix expansion by CMR in infiltrative heart disease. JACC Cardiovasc Imaging 2012;5:897-907 Epub 2012/09/15.

    Article  PubMed  PubMed Central  Google Scholar 

  16. Banypersad SM, Sado DM, Flett AS, Gibbs SD, Pinney JH, Maestrini V, et al. Quantification of myocardial extracellular volume fraction in systemic AL amyloidosis: an equilibrium contrast cardiovascular magnetic resonance study. Circ Cardiovasc Imaging 2013;6:34-9 Epub 2012/11/30.

    Article  PubMed  Google Scholar 

  17. Klunk WE, Engler H, Nordberg A, Wang Y, Blomqvist G, Holt DP, et al. Imaging brain amyloid in Alzheimer’s disease with Pittsburgh Compound-B. Ann Neurol 2004;55:306-19 Epub 2004/03/03.

    Article  CAS  PubMed  Google Scholar 

  18. Antoni G, Lubberink M, Estrada S, Axelsson J, Carlson K, Lindsjo L, et al. In vivo visualization of amyloid deposits in the heart with 11C-PIB and PET. J Nucl Med 2013;54:213-20 Epub 2012/12/15.

    Article  CAS  PubMed  Google Scholar 

  19. Dorbala S, Vangala D, Semer J, Strader C, Bruyere JR Jr, Di Carli MF, et al. Imaging cardiac amyloidosis: a pilot study using (1)(8)F-florbetapir positron emission tomography. Eur J Nucl Med Mol Imaging 2014;41:1652-62 Epub 2014/05/21.

    Article  CAS  PubMed  Google Scholar 

  20. Furukawa K, Ikeda S, Okamura N, Tashiro M, Tomita N, Furumoto S, et al. Cardiac positron-emission tomography images with an amyloid-specific tracer in familial transthyretin-related systemic amyloidosis. Circulation 2012;125:556-7 Epub 2012/01/25.

    Article  PubMed  Google Scholar 

  21. Nesterov SV, Han C, Maki M, Kajander S, Naum AG, Helenius H, et al. Myocardial perfusion quantitation with 15O-labelled water PET: high reproducibility of the new cardiac analysis software (Carimas). Eur J Nucl Med Mol Imaging 2009;36:1594-602 Epub 2009/05/02.

    Article  PubMed  Google Scholar 

  22. Thie JA. Clarification of a fractional uptake concept. J Nucl Med 1995;36:711-2 Epub 1995/04/01.

    CAS  PubMed  Google Scholar 

  23. Cerqueira MD, Weissman NJ, Dilsizian V, Jacobs AK, Kaul S, Laskey WK, et al. Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart. A statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association. Int J Cardiovasc Imaging 2002;18:539-42 Epub 2002/07/24.

    PubMed  Google Scholar 

  24. Zhang S, Smailagic N, Hyde C, Noel-Storr AH, Takwoingi Y, McShane R, et al. (11)C-PIB-PET for the early diagnosis of Alzheimer’s disease dementia and other dementias in people with mild cognitive impairment (MCI). Cochrane Database Syst Rev. 2014;7:CD010386 Epub 2014/07/24.

    PubMed  Google Scholar 

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Acknowledgments

We wish to express our thanks to the staff at the PET Centre at Uppsala University Hospital for their assistance with the scans and to Prof Juhani Knuuti and Dr Chunlei Han at Turku PET Centre for kind assistance with Carimas software.

Conflict of interest

The authors have indicated that they have no financial conflict of interest.

Author information

Authors and Affiliations

  1. Department of Nuclear Medicine & PET, Uppsala University, Uppsala, Sweden

    Tanja Kero MD, Lars Lindsjö, Jens Sörensen MD, PhD & Mark Lubberink PhD

Authors
  1. Tanja Kero MD
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  2. Lars Lindsjö
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  3. Jens Sörensen MD, PhD
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  4. Mark Lubberink PhD
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Corresponding author

Correspondence to Tanja Kero MD.

Additional information

See related editorial, doi:10.1007/s12350-015-0235-z

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Cite this article

Kero, T., Lindsjö, L., Sörensen, J. et al. Accurate analysis and visualization of cardiac 11C-PIB uptake in amyloidosis with semiautomatic software. J. Nucl. Cardiol. 23, 741–750 (2016). https://doi.org/10.1007/s12350-015-0149-9

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  • DOI: https://doi.org/10.1007/s12350-015-0149-9

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