Abstract
Introduction
Many fibrosing interstitial lung diseases (ILDs) develop a chronic progressive phenotype. While idiopathic pulmonary fibrosis, which is always progressive, is well characterized with established treatment options, the epidemiology of other chronic fibrosing ILDs with a progressive phenotype has not been widely investigated. Treatment options are limited, with a high unmet need. This claims database study estimates the incidence and prevalence of these diseases in the USA.
Methods
Diagnosis, procedure and resource utilization codes from insurance claims were used to identify patients with fibrosing ILD and those with a chronic progressive phenotype among 37,565,644 adult patients in the IBM® MarketScan® Research Database 2012–2015. Two eligible ILD claims were required for a fibrosing ILD diagnosis. Progression was defined using a novel algorithm constituted by criteria considered proxies for progression. Patients were defined as having incident (new) or existing diagnoses based on claims during a 365-day period before study entry.
Results
The estimated age- and sex-adjusted prevalence per 100,000 persons of fibrosing ILD (95% confidence interval) was 117.82 (116.56, 119.08) and of chronic fibrosing ILDs with a progressive phenotype was 70.30 (69.32, 71.27). The estimated adjusted incidence per 100,000 patient-years of fibrosing ILD was 51.56 (50.88, 52.24) and of chronic fibrosing ILDs with a progressive phenotype was 32.55 (32.01, 33.09). Among incident fibrosing ILD patients, 57.3% experienced progression over a median of 117 days (interquartile range 63–224), with largely comparable rates of progression among different diseases.
Conclusions
Chronic fibrosing ILDs with a progressive phenotype comprise a relatively new disease construct requiring varied approaches to obtain reliable estimates of prevalence and incidence. This is the first large claims database study using real-world data to provide estimates of the prevalence and incidence of these diseases among a very large segment of the US population and could form the groundwork for future studies.
Plain Language Summary
Progressive lung fibrosis occurs in idiopathic pulmonary fibrosis; however, interstitial lung fibrosis may occur in other diseases such as rheumatoid arthritis, chronic hypersensitivity pneumonitis and sarcoidosis, and may or may not be progressive in these diseases. Little is known about the frequency of lung fibrosis among patients with these diseases or how often such fibrosis is progressive. This study used information from a large insurance claims database (IBM® MarketScan®) to estimate the frequency and progression of lung fibrosis associated with different diseases.
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Why carry out this study? |
Treatment options for chronic fibrosing ILDs with a progressive phenotype other than idiopathic pulmonary fibrosis are limited, with a high unmet need |
The epidemiology of these diseases has not been widely investigated |
This claims database study estimates their incidence and prevalence in the USA |
What was learned from the study? |
The estimated age- and sex-adjusted prevalence per 100,000 persons of fibrosing ILD (95% confidence interval) was 117.82 (116.56, 119.08) and of chronic fibrosing ILDs with a progressive phenotype was 70.30 (69.32, 71.27) |
The estimated incidence per 100,000 patient-years of fibrosing ILD was 51.56 (50.88, 52.24) and of chronic fibrosing ILDs with a progressive phenotype was 32.55 (32.01, 33.09) |
This is the first such study to provide estimates of prevalence and incidence of these diseases and could form the groundwork for future studies |
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Introduction
Interstitial lung disease (ILD) encompasses a large group of disorders that can be characterized by fibrosis of the lungs. Idiopathic pulmonary fibrosis (IPF), which is always progressive, is one of the most common and most studied of the ILDs [1,2,3]. Other ILDs may or may not have a progressive phenotype and include idiopathic interstitial pneumonias (IIPs), hypersensitivity pneumonitis, exposure-related ILD such as pneumoconiosis, sarcoidosis, and ILDs associated with connective tissue disease and autoimmune disease [1,2,3].
Chronic fibrosing ILDs other than IPF that have a progressive phenotype are increasingly referred to as ‘progressive fibrosing ILD’ [2, 4,5,6,7]. They appear to share a common pathology, characterized by increasing extent of fibrosis on high-resolution computed tomography (HRCT), declining lung function, worsening symptoms, and early mortality [3]. There is a high medical need for effective treatment. One treatment, nintedanib, which was previously approved to slow lung function decline in SSc-ILD [8, 9], is now approved for treatment of patients with chronic fibrosing ILDs with a progressive phenotype [10].
Given the clinical and pathophysiologic similarities between progressive fibrosing ILDs, it has been postulated that the progressive phenotype involves a common pathologic mechanism regardless of cause, and thus these diseases could respond to similar treatment. Antifibrotic treatment with nintedanib has been evaluated in progressive fibrosing ILD with convincing results [11] that contributed to the approval in the US [10] and in 45 other countries, including Japan [12], Canada [13], and the European Union [14]. However, devising effective strategies for appropriate disease management and allocation of resources for this condition is hampered by limited understanding of its epidemiology.
Rare disease frequencies are inherently difficult to quantify at a population level, and the relatively recent emergence of progressive fibrosing ILD as a disease concept that combines an underlying disease, lung fibrosis, and a progressive phenotype makes it further challenging to quantify. Various approaches to data generation are required to build a complete evidence base of disease frequencies over time, and these estimates need to be fine-tuned until a range of plausible estimates can be achieved. These approaches include smaller clinic-based studies with potentially valid estimates derived from review of complete data directly accessible from patient charts but based on small numbers of patients, and larger claims database studies, which offer the strength of including very large numbers of patients, but do not allow for direct access to all clinically relevant data available in patient charts. Not surprisingly, data on overall prevalence and incidence of progressive fibrosing ILD are limited.
Progressive fibrosing ILD is increasingly being accepted as a disease concept [3, 15,16,17,18]. However, publications have focused on aspects of pathogenesis, diagnosis, and disease management, with few data available on prevalence and incidence. Wijsenbeek et al. [15] reported that 18–32% of ILDs other than IPF were estimated to progress, according to physician surveys. The prevalence of progressive fibrosing ILDs has been estimated at up to 28 per 100,000 persons, based on the prevalence of fibrosing ILDs and survey-derived estimates of how many patients develop a progressive phenotype [19,20,21,22,23,24].
To complement the existing evidence base, we have conducted the first large database study using medical insurance claims to identify patients with progressive fibrosing ILD using diagnostic and procedure/resource utilization codes in insurance claims and to then estimate the prevalence and incidence of progressive fibrosing ILD in this large population of patients. This approach allows estimation of the overall burden of progressive fibrosing ILD in the US population and provides valuable information on the prevalence and incidence of this group of conditions that has not been well described.
Methods
Study Design
This study used data from the IBM® MarketScan® Research Databases of US medical and prescription commercial claims to assess the prevalence and incidence of fibrosing ILD and progressive fibrosing ILD, both overall and by different underlying diseases. Codes included on claims for diagnoses (International Classification of Diseases, Ninth Revision, Clinical Modification [ICD-9 CM]) [25] and for procedures (Current Procedural Terminology, 4th Edition [CPT-4]), prescriptions, and resource utilization were used to identify patients with fibrosing ILD and, among this patient group, those with a progressive phenotype. In the absence of existing validated algorithms or previously published data to guide this process, a combination of codes was selected in consultation with practicing pulmonologists to capture both the fibrosing ILD and the progressive phenotype through proxy criteria.
Patients
Patients aged at least 18 years were required to have a period of 365 days with continuous medical and pharmacy insurance coverage (baseline period) before study entry. After entry to the study, patients were required to maintain coverage up to the time of diagnosis of fibrosing ILD and/or progressive fibrosing ILD. Gaps of up to 30 days in coverage were permitted.
Identification of Fibrosing ILD
Eligible ICD-9 codes for a diagnosis of fibrosing ILD are shown in the supplementary material (Table S1). The code for IPF (516.31) was not eligible, although patients with this code were not excluded if they had another eligible code. Given the lack of precedence on attempting to identify fibrosing ILD patients using codes on claims in a large insurance database, two approaches were considered. Initially, because it was thought that a highly sensitive algorithm might be required to capture the outcome of interest, a single claim with a diagnostic code for lung fibrosis as indicated above was used as a diagnosis of fibrosing ILD. Subsequently, the narrower, more specific definition that required a second claim for one of the fibrosing ILD codes listed above within 30–365 days of the first was used to establish a diagnosis. Since this more specific definition excludes patients who did not survive or remain in the database long enough to satisfy the criteria, the second claim was considered to be the index date for study entry to eliminate the potential for selection bias [26].
For both definitions, incident cases of fibrosing ILD comprised patients without an eligible code during the baseline period prior to the initial claim. All others were considered existing cases. Prevalent cases included both incident and existing cases.
Identification of Progressive Fibrosing ILD
Patients with progressive fibrosing ILD were a subgroup of the fibrosing ILD cohort. In the absence of diagnostic or procedure codes on lung function and imaging methods specific to the assessment of ILD progression in clinical practice, proxies for progression based on plausible markers of progression were selected in consultation with expert pulmonologists based on their clinical experience. Patients were considered to have progressive fibrosing ILD if they satisfied any of the following criteria for progression: ≥ 2 pulmonary function tests or ≥ 2 oxygen titration tests within 90 days, ≥ 2 HRCT or ≥ 3 chest computed tomography (CT) scans within 360 days, respiratory hospitalization, palliative care, lung transplant, any use of oxygen therapy or a corticosteroid > 20 mg, or new use of immunosuppressive therapy. A sensitivity analysis was conducted in which clinical guidance was used to identify proxy criteria that may potentially be too sensitive: first, oxygen titration tests and use of corticosteroids were omitted as criteria for progression; second, respiratory hospitalization was retained, but only if there were two instances within 360 days; and oxygen therapy was retained only if there were two recorded claims during the study period.
Incident progressive fibrosing ILD cases included all patients with proxies for progression on or after the date of diagnosis of incident fibrosing ILD. Patients with existing fibrosing ILD (i.e., with a claim for fibrosing ILD during the baseline period) were also considered to have incident progressive fibrosing ILD if they had a proxy for progression on or after the date of the existing fibrosing ILD claim, without any of the proxies for progression during the baseline period.
Identification of Underlying Disease
An underlying clinical diagnosis category was assigned based on diagnosis and lung fibrosis code(s) identified on claims during the baseline period. Patients without any of the specific diagnosis codes were categorized as having idiopathic non-specific interstitial pneumonia or unclassifiable IIPs based on ICD-9 CM algorithms or as having ‘no underlying condition’ if none of the algorithms applied. If patients had multiple eligible codes, that nearest to the date of diagnosis was used. Those with eligible codes for different conditions on the same day were categorized as having multiple underlying conditions. Diagnosis and lung fibrosis codes used in categorization of the underlying diagnoses are provided in the supplementary material (Table S2).
Outcomes
The primary outcomes were the crude and age- and sex-adjusted (standardized to the 2014 US Census estimates) prevalence and incidence rates of fibrosing ILD and progressive fibrosing ILD. Secondary outcomes included the age and sex distribution, the prevalence and incidence rates by age and sex and by underlying clinical diagnosis, and the proportion of patients with fibrosing ILD who subsequently progressed, overall and by underlying clinical diagnosis.
Statistical Methods
All analyses were descriptive. Crude prevalences were calculated by dividing the total number of patients with incident and existing diagnosis by the total number of eligible patients in the database. The crude incidence rate was calculated by dividing the number of patients with an incident diagnosis by the sum of follow-up time for all eligible participants. Follow-up time was calculated starting when a patient had completed 365 days of continuous eligibility (baseline period). For calculation of follow-up time, patients were censored on the date of a diagnosis of fibrosing ILD or progressive fibrosing ILD, discontinuation of insurance, death, or the end of the study period.
All analyses were conducted using the Aetion Evidence Platform® (2020), v3.19, software for real-world data analysis, which has been validated for a range of studies [27]. The use of this de-identified data source was approved for exemption by the New England Independent Review Board (NEIRB).
For age- and sex-standardized rates, crude prevalence and incidence rates were calculated for age strata among males and females and weights assigned to each stratum based on the 2014 US Census estimates. The crude estimates for each stratum were multiplied by the corresponding stratum weight and weighted rates summed to provide age- and sex-adjusted rates.
Results
Prevalence and Incidence Rates of Fibrosing ILD and Progressive Fibrosing ILD
A total of 37,565,644 patients aged at least 18 years were identified from 1 October 2012 to 30 September 2015 with at least 365 days’ continuous enrollment. Of these, 147,678 (0.39%) had at least one claim for lung fibrosis, yielding a crude prevalence of fibrosing ILD of 393.12 per 100,000 persons (95% confidence interval [CI] 391.12, 395.12), using the sensitive (single-claim) definition. When the specific definition, requiring two claims, was used for diagnosis, 35,825 (0.10%) patients were identified as having fibrosing ILD, yielding a crude prevalence of 95.37 per 100,000 persons (95% CI 94.38, 96.35). When adjusted for age and sex, the prevalence increased to 453.88 per 100,000 persons (95% CI 451.46, 456.29) using the sensitive definition and to 117.82 per 100,000 persons (95% CI 116.56, 119.08) using the specific definition of fibrosing ILD (Table 1). Patients with progressive fibrosing ILD were a subset of the fibrosing ILD cohort, and using two claims to define fibrosing ILD, the crude prevalence of progressive fibrosing ILD was 57.82 per 100,000 persons (95% CI 57.05, 58.58), increasing to 70.30 per 100,000 persons (95% CI 69.32, 71.27) when adjusted for age and sex. Crude and age- and sex-adjusted prevalence and incidence rates using both definitions are summarized in Table 1.
Analyses using the specific, two-claim definition of fibrosing ILD are presented below, while estimates using the less specific, more sensitive, single-claim definition are available in the supplementary material (Tables S3 and S4).
During a median follow-up of 1.25 years, a total of 21,719 patients satisfied the proxy criteria indicating progression, representing 60.1% of all fibrosing ILD patients. Of these, 14,722 (67.8%) were incident cases whereas 6977 (32.2%) were existing cases (i.e., they fulfilled criteria for progression at the time of study entry).
Most of the incident cases of progression (13,518/14,722, 91.8%) were derived from the incident fibrosing ILD cohort (n = 23,577), representing 57.3% of this cohort, with progression seen over a median of 117 days (interquartile range [IQR] 63–224 days) from the first of the two lung fibrosis claims (Table 2). Median time from the date of the second claim (index date) to the first proxy for progression was 12 days (IQR 0–55 days).
Distribution of Underlying Disease Categories in the Study Cohorts
The distribution of underlying diseases was comparable in the fibrosing ILD and progressive fibrosing ILD incident cohorts. Approximately three-quarters of patients were categorized as having unclassifiable IIP. Rheumatoid arthritis-associated ILD (RA-ILD) (7.6% of fibrosing ILD cases and 7.7% of progressive fibrosing ILD) and sarcoidosis (7.3% and 5.4%, respectively) were the next most common categories (Fig. 1). The distribution of patients progressing did not differ markedly according to underlying disease category, with the exception of sarcoidosis, which had the lowest percent of patients who progressed (42.8%) over a median (IQR) of 148 (73–255) days, and hypersensitivity pneumonitis, which had the highest percent (74.2%) over a median (IQR) of 109 (63–232) days (Table 2).
Distribution of underlying clinical diagnosis in patients assessed as having a incident fibrosing ILD and b incident progressive fibrosing ILD. The high proportion of patients classed as having unclassifiable ILD is likely to be a consequence of coding practices, where the code for unclassifiable ILD is used initially and not updated when another diagnosis is made. Patients categorized as ‘other’ had a claim for an underlying condition but did not satisfy any of the specific coding algorithms. CTD connective tissue disease, HP hypersensitivity pneumonitis, IIP idiopathic interstitial pneumonia, ILD interstitial lung disease, iNSIP idiopathic non-specific interstitial pneumonia, MCTD mixed connective tissue disease, RA rheumatoid arthritis, SSc systemic sclerosis
Age and Sex Distribution of Fibrosing ILD and Progressive Fibrosing ILD
The prevalence of fibrosing ILD was slightly lower in males than in females, but the prevalence of progressive fibrosing ILD was similar in males and females (Table 3). For both fibrosing ILD and progressive fibrosing ILD, the crude incidence rate was similar for males and females, and at least two-thirds of patients were aged > 60 years. Incidence increased steadily with age: the incidence rate in patients aged 50–59 years was ten times that in patients aged < 40 years, while in those aged ≥ 80 years the incidence rate was 100 times that in the < 40 years group (Table 4). There was no evidence for a higher occurrence of progression within any age group.
Distribution of Proxy Criteria Used to Define Progression
To identify the main drivers of progressive fibrosing ILD diagnosis in this population, the distribution of proxy criteria used to define progression was analyzed. For completeness, the distribution of criteria was analyzed in all patients who had a proxy for progression, including those with only one claim for fibrosing ILD. Of 49,377 patients with a qualifying claim for incident progression, 44,672 (90.5%) qualified based on only one proxy criterion. Oxygen therapy was the most common proxy, seen in 28.3% of progression claims overall and 27.6% of those with only one proxy. Other frequently used proxies were respiratory hospitalization (14.5% overall, 12.7% of those with one proxy), ≥ 2 pulmonary function tests within 90 days (15.0% overall, 14.1% of those with one proxy), ≥ 2 HRCT scans within 360 days (22.0% overall, 14.5% of those with one proxy), and three or more chest CT scans within 360 days (19.9% overall, 12.3% of those with one proxy). Other criteria for progression were found in < 3% of patients (Fig. 2). Findings were similar in the overall cohort with incident or existing progressive fibrosing ILD (Figure S1).
Proxy criteria for progression applied during the study in patients with incident progressive fibrosing ILD. Criteria were not mutually exclusive, and an individual patient could have more than one criterion applied. The majority of patients (90.5%) had only one proxy applied, and data are shown a for all patients and b for those with only one proxy applied. CT computed tomography, HRCT high-resolution computed tomography, ILD interstitial lung disease
Sensitivity Analysis of Proxy Criteria for Progression
Removing claims for oxygen titration tests and corticosteroids as criteria and requiring two respiratory hospitalizations within 360 days or two claims for oxygen therapy for these to be proxy criteria led to very similar results, with no changes to the incidence and prevalence rates and median time to progression changed from 117 to 122 days. It was concluded that these potentially more sensitive progression proxies were not strong drivers of the observed prevalence and incidence estimates.
Discussion
Progressive fibrosing ILDs other than IPF have been considered as a distinct group only relatively recently, and there are no published data from large studies on their overall epidemiology. Estimation of the prevalence and incidence rates has been limited to relatively small, clinic-based studies [19,20,21], and real-world data on larger populations are needed.
This is the first large study using a claims database to estimate the prevalence and incidence rates of fibrosing ILD and progressive fibrosing ILD. We initially used a broad, sensitive definition to define fibrosing ILD, requiring only one claim for a diagnosis. However, these are complex conditions that may be difficult to diagnose and are frequently only diagnosed some time after the onset of symptoms. Diagnosis codes, particularly in the early stages, may be driven by reimbursement considerations rather than clinical diagnosis, and a single claim for ‘lung fibrosis’ may not necessarily indicate a diagnosis of fibrosing ILD. We found that a more specific definition, requiring two claims, produced estimates of the prevalence and incidence of fibrosing ILD more in line with clinic-based studies. Both estimates are provided, though we focus on the more specific definition, with which we have estimated the age- and sex-adjusted prevalence of progressive fibrosing ILD to be 70.33 per 100,000 persons and the incidence to be 32.55 per 100,000 patient-years. This is higher than what has been previously reported (prevalence of progressive fibrosing ILDs up to 28 per 100,000 persons) in clinic-based studies [19,20,21]. Although there was a high proportion of patients in the ‘unclassifiable IIP’ group, the distribution of underlying conditions among other patients was comparable to previous findings [19,20,21], with RA-ILD and sarcoidosis most common. The prevalence of both fibrosing ILD and progressive fibrosing ILD increased markedly with age, as would be anticipated. In the absence of precise validated estimates, our study may provide potential upper limits for the true estimates of prevalence and incidence, whereas clinic-based studies may provide potential lower limits.
Given the lack of a code for progressive fibrosing ILD at the time the study was conducted and the absence of other claims database studies, progression was defined using proxy measures (as plausible markers of actual progression) that have not been validated. The most common proxies were claims for oxygen therapy and respiratory hospitalization and frequency of pulmonary function tests, chest CT scans, and HRCT scans. To ensure that single instances of oxygen therapy and respiratory hospitalization did not result in inclusion of patients that were not truly progressing, we conducted a sensitivity analysis requiring at least two claims for these two proxies that also excluded claims for oxygen titration tests and corticosteroids to create a stricter definition of progression. This led to minimal changes in results with no meaningful impact on the conclusions of the study.
Using the specific definition of fibrosing ILD, more than half of patients experienced progression within a median of 117 days (IQR 63–224 days) after presentation. There were few differences in the rate of progression by age, sex, or underlying diagnosis, except for sarcoidosis, where just under half of patients progressed according to these proxies. The proportion of progression reported in patients with fibrosing ILD in the current study is somewhat higher than has been previously suggested [15, 18,19,20,21]. This seems to be true both for the population overall and for individual diseases; in particular, the proportion of patients with sarcoidosis and progressive fibrosing ILD seems higher than has been reported previously and higher than is generally seen in clinical practice [28]. However, comparisons are difficult as methodologies used to estimate prevalence and incidence are variable. Possibly our estimates may represent the upper limit of the likely prevalence and incidence of these conditions, with patients included in the estimates that may have been excluded if clinical data were available. For instance, patients with a stable fibrosing ILD may require oxygen therapy to manage exertional dyspnea, meeting the criteria for progression in our analysis and potentially contributing to higher estimates for incidence and prevalence of the progressive phenotype than have been previously reported. Nevertheless, while the claims-based proxies for clinical progression may have been overly sensitive and led to some overestimation, this study makes an important contribution to the growing body of knowledge in this area by being the first to provide estimates of progressive fibrosing ILD from a very large population.
The current study has limitations, including relying solely on claims data without access to clinical data, which may lead to overestimates of the prevalence of fibrosing ILD/progressive fibrosing ILD, as confirmatory clinical data would increase the likelihood of identifying true cases and excluding patients without these conditions. In addition, progressive fibrosing ILD is a relatively new disease construct with multiple components (including ILD, an underlying disease and a progressive phenotype) and has a lengthy and potentially complicated diagnostic pathway, with an algorithm that has not yet been validated. The crucial factor in identification in a claims study is the code entered by the physician. The ILD category may often be assigned early in the disease history when full diagnosis has not been made. Notably, a very high percentage of patients in the current study were categorized as ‘unclassifiable IIP.’ Most patients in this group were identified through the diagnostic code for post-inflammatory fibrosis (515) (n = 9716; 87.9%) at time of diagnosis, which is often used during diagnostic workup. In our study, patients were censored at date of diagnosis of progression, so it is unknown how diagnosis may have changed or been further specified during follow-up. In addition, more specific diagnoses may be made in patient documentation unavailable in the database, with no billing incentive for clinicians to update the claim. In general, it is possible that a code used initially for making a preliminary diagnosis was not updated when additional information became available, obscuring the true distribution of underlying diseases. In some cases, an IPF code may have appeared later in the follow-up as the final diagnosis, particularly for those who initially received a diagnosis of unclassifiable IIP. It was not possible to examine this because patients were censored at the date of diagnosis of progression.
The primary analysis of the current study was standardized by age and sex to the 2014 US population census estimates, but care should be taken in considering generalizability. The population under consideration excluded uninsured patients, so likely excluded many patients from lower socioeconomic backgrounds. Race is not captured in IBM® MarketScan® so we were unable to determine whether the findings of this study are applicable to all racial groups.
Progressive fibrosing ILD is a disease with a high unmet need, and well-designed clinical studies are required to optimize treatment strategies. Understanding the epidemiology of progressive fibrosing ILD is essential, but is further complicated by the grouping together of different ILDs that share a progressive phenotype. While a claims database study has the benefit of size, it remains limited by the reliance on physician coding. Because no specific code existed for progressive fibrosing ILD at the time of the study, a large database was required to estimate prevalence and incidence using proxy codes. We have categorized ILDs as incident or existing based on claims during the baseline period, but the absence of a claim does not guarantee that a patient did not have the disease during this period.
Conclusions
The limitations associated with a claims database notwithstanding, this is the first study to our knowledge providing insight into the prevalence and incidence of progressive fibrosing ILD and the likelihood of developing a progressive phenotype, using a very large population. The evidence provides a foundation for further studies to validate algorithms to identify patients and provide essential information on the epidemiology of progressive fibrosing ILD to help develop effective treatment strategies.
Further studies are needed to refine and/or replicate these findings and to maximize validity and reliability of these estimates. The findings serve as a strong beginning to the process of evidence generation for estimation of the prevalence and incidence of progressive fibrosing ILD, particularly in the absence of validated algorithms and no ICD code. Validation of the algorithm and additional data generation are needed as a next step, until a unique ICD-10 code for progressive fibrosing ILD becomes widely used and integrated into clinical practice.
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Acknowledgements
We wish to thank Julia A. Pisc and Jocelyn R. Wang of Aetion, Inc., contracted by Boehringer Ingelheim, for their contributions to the analytic implementation.
Funding
The study was sponsored by Boehringer Ingelheim Inc., Ridgefield, CT, USA, and the Rapid Service fee was funded by Boehringer Ingelheim International GmbH, Ingelheim am Rhein, Germany.
Authorship
All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published.
Authors contributions
All authors were involved in developing the concept and design of the study. RLB developed the protocol and report. EMG supervised the conduct of the analyses. All authors contributed to the drafting and critical review of the manuscript and approved the final version.
Medical writing, editorial, and other assistance
Medical writing support was provided by John Carron, PhD, of Nucleus Global, funded by Boehringer Ingelheim International GmbH, Ingelheim am Rhein, Germany.
Disclosures
Amy L Olson has participated in a speaker’s bureau for Boehringer Ingelheim. Since this study, she has become an employee of Boehringer Ingelheim. Padmaja Patnaik, Nadine Hartmann and Laura Wallace are employees of Boehringer Ingelheim. Rhonda L Bohn is a paid consultant for Boehringer Ingelheim. Elizabeth M Garry is a full-time employee of Aetion, Inc., of which she holds stock options. Aetion was contracted by Boehringer Ingelheim to execute the analyses used to generate the results of this study, but she received no direct payment.
Compliance with ethics guidelines
The use of this de-identified data source was approved for exemption by the New England Independent Review Board (NEIRB).
Data availability
The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.
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Olson, A.L., Patnaik, P., Hartmann, N. et al. Prevalence and Incidence of Chronic Fibrosing Interstitial Lung Diseases with a Progressive Phenotype in the United States Estimated in a Large Claims Database Analysis. Adv Ther 38, 4100–4114 (2021). https://doi.org/10.1007/s12325-021-01786-8
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DOI: https://doi.org/10.1007/s12325-021-01786-8