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Surgical Indications in Hypophosphataemic Rickets

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Abstract

Low levels of phosphate in blood secondary to a lack of phosphorous reabsorption in the renal tubule cause hypophosphataemic rickets. To increase blood calcium levels, bone calcium is released into the bloodstream by increasing the activity of osteoclasts in the bones. These alterations in bone metabolism lead to delayed growth and small height, diffuse bone pain, bone fragility with microfractures, and frequent fractures and bone deformities. Although management of some of these conditions is mainly conservative, in cases of bone deformities or severe osteomalacia surgery should be considered: from minimally invasive surgical techniques of guided growth in patients with less deformity and open physeal cartilage to correction osteotomies in three-dimensional deformities. This article briefly reviews the indications for surgery procedures to be performed in these patients, highlighting when to use aggressive and non-aggressive approaches.

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Acknowledgements

This supplement has been funded by Kyowa Kirin.

Funding

Kyowa Kirin organized the scientific meeting and contributed to the financing of the publication of the opinion of the speakers presented at that meeting (Madrid, November 2018).

Medical Writing Assistance

The author would like to thank Fernando Sánchez Barbero, PhD, Anabel Herrero, PhD, and Ana María Palma Nieto for providing medical writing assistance and translation on behalf of Springer Healthcare. Kyowa Kirin funded the writing assistance provided by Springer Healthcare Ibérica S.L. Ruth Blaikie provided the copy editing of this manuscript.

Authorship

The author meets the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, takes responsibility for the integrity of the work as a whole and has given her approval for this version to be published.

Disclosures

Ana M. Bueno-Sánchez has nothing to disclose.

Compliance with Ethics Guidelines

This article is based on previously conducted studies and does not contain any new studies with human participants or animals performed by the author.

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Authors and Affiliations

  1. Jefa de Sección de Traumatología Infantil, Departamento de Traumatología y Cirugía Ortopédica Infantil, Hospital Universitario de Getafe, Getafe, Madrid, Spain

    Ana M. Bueno-Sánchez

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  1. Ana M. Bueno-Sánchez
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Correspondence to Ana M. Bueno-Sánchez.

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Bueno-Sánchez, A.M. Surgical Indications in Hypophosphataemic Rickets. Adv Ther 37 (Suppl 2), 113–120 (2020). https://doi.org/10.1007/s12325-019-01179-y

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  • DOI: https://doi.org/10.1007/s12325-019-01179-y

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