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Effect of Intraventricular Hemorrhage on Cerebellar Growth in Preterm Neonates

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Abstract

The aim of this study is to evaluate cerebellar growth of preterm infants with intraventricular hemorrhage. Vermis height (VH) and transverse cerebellar diameter (TCD) were measured by cranial ultrasound in 18 preterm infants (26–30 weeks) with intraventricular hemorrhage (IVH) at first 3 days of life and at term equivalent age (TEA). IVH was diagnosed by ultrasonography and scaled in accordance with the definitions by Papile et al. Measurements were compared with 18 preterm (26–30 weeks) infants without IVH. Both VH and TCD of preterm infants with IVH were significantly lower than those of preterm ones without IVH at TEA (p < 0.001). No significant difference was found for head circumference (p = 0.158) and weight (p = 0.092). In subgroup analysis, preterm infants with grades 3–4 IVH had significantly lower TCD (p = 0.008) and head circumference (p = 0.033) than the ones with grades 1–2 IVH. However, VH (p = 0.102) and weight (p = 0.480) did not show any difference between these subgroups. IVH may have a significant impact on cerebellar growth on preterm infants at TEA, specially those with a severe IVH. TCD is affected more than VH.

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Authors and Affiliations

  1. Neonatal Intensive Care Unit, Training and Research Hospital, Abant Izzet Baysal University, Gölköy Yerleşkesi, Merkez/Bolu, 14280, Bolu-Asya, Turkey

    Selim Sancak

  2. Neonatal Intensive Care Unit, Koc University School of Medicine, Istanbul, Turkey

    Tugba Gursoy

  3. Neonatal Intensive Care Unit, Zeynep Kamil Maternity and Children’s Training and Research Hospital, Istanbul, Turkey

    Guner Karatekin

  4. Neonatal Intensive Care Unit, Medeniyet University, Istanbul, Turkey

    Fahri Ovali

Authors
  1. Selim Sancak
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  2. Tugba Gursoy
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  3. Guner Karatekin
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  4. Fahri Ovali
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Corresponding author

Correspondence to Selim Sancak.

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Written parental consent was obtained from the parents and local ethics committee approved the study protocol.

Funding

The research being reported in this publication was not supported by any sponsor.

Conflict of Interest

The authors declare that they have no competing interests.

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Sancak, S., Gursoy, T., Karatekin, G. et al. Effect of Intraventricular Hemorrhage on Cerebellar Growth in Preterm Neonates. Cerebellum 16, 89–94 (2017). https://doi.org/10.1007/s12311-016-0766-0

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  • DOI: https://doi.org/10.1007/s12311-016-0766-0

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