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Longitudinal Changes in Cerebellar and Thalamic Spontaneous Neuronal Activity After Wide-Awake Surgery of Brain Tumors: a Resting-State fMRI Study

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Abstract

Hypometabolism has been observed in the contralesional cerebellar hemisphere after various supratentorial cortical lesions. It is unknown whether the consequences of the dee- and deafferentation subsequent to wide-awake surgery for brain diffuse low-grade glioma can be assessed within remote and unresected subcortical structures such as the cerebellum or thalamus. To answer this question, we have conducted several regional analyses. More specifically, we have performed amplitude of low-frequency fluctuations (neuronal activity magnitude) and regional homogeneity (local temporal correlations) analyses on resting state functional magnetic resonance imaging (rs-fMRI) data and at different time points, before and after surgery. Our main results demonstrated that it is possible to evaluate subtle subcortical changes using these tools dedicated to the analysis of rs-fMRI data. The observed variations of spontaneous neuronal activity were particularly significant within the cerebellum which showed altered regional homogeneity and neuronal activity intensity in very different, specialized and non-overlapping subregions, in accordance to its neuro-anatomo-functional topography. These variations were moreover observed in the immediate postoperative period and recovered after 3 months.

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Conflict of Interest

The authors declare that they have no competing interests.

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    Authors and Affiliations

    1. INRIA, LIRMM, équipe DEMAR, University of Montpellier 2, 860 rue Sainr Priest, 34095, Montpellier, France

      Anthony Boyer & François Bonnetblanc

    2. Cognition, Action et Plasticité Sensorimotrice, INSERM U-1093, UFR STAPS, Université de Bourgogne, 27877, Dijon, France

      Anthony Boyer & François Bonnetblanc

    3. I2FH, Institut d’Imagerie Fonctionnelle Humaine, Hôpital Gui de Chauliac, Centre Hospitalier Régional Universitaire de Montpellier, 34295, Montpellier, France

      Jérémy Deverdun, Emmanuelle Le Bars & Nicolas Menjot de Champfleur

    4. Theoretical Physics Group, Université Montpellier II, 34095, Montpellier, France

      Jérémy Deverdun & François Molino

    5. Département de Neurochirurgie, Hôpital Gui de Chauliac, 34295, Montpellier, France

      Hugues Duffau

    6. Plasticity of Central Nervous System, Stem Cells and Glial Tumours, U1051, Institut of Neurosciences of Montpellier, Saint Eloi Hospital, 34295, Montpellier, France

      Hugues Duffau & Nicolas Menjot de Champfleur

    7. Département d’imagerie médicale, CHRU Caremeau, Nîmes, France

      Nicolas Menjot de Champfleur

    8. Institut Universitaire de France, Paris, France

      François Bonnetblanc

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    1. Anthony Boyer
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    Correspondence to François Bonnetblanc.

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    Nicolas Menjot de Champfleur and François Bonnetblanc contributed equally to this work.

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    Boyer, A., Deverdun, J., Duffau, H. et al. Longitudinal Changes in Cerebellar and Thalamic Spontaneous Neuronal Activity After Wide-Awake Surgery of Brain Tumors: a Resting-State fMRI Study. Cerebellum 15, 451–465 (2016). https://doi.org/10.1007/s12311-015-0709-1

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