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Role of PACAP in Controlling Granule Cell Migration

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Abstract

Pituitary adenylate cyclase-activating polypeptide (PACAP), a neuropeptide, regulates a wide variety of cellular functions, but little is known about its role in neuronal cell migration. Recent studies revealed that PACAP has short-term, cortical layer-specific effects on neuronal cell migration. In this article, we focus on the role of PACAP in controlling the migration of cerebellar granule cells.

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Acknowledgements

We thank Y. Komuro for critically reading the manuscript. Work reported in this review was supported by a Pilot Research Award (PP1450) from the National Multiple Sclerosis Society and a grant (R01 ES015612) from National Institute of Environmental Health Sciences.

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Authors and Affiliations

  1. Department of Neurosciences, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, 44195, OH, USA

    Donald Bryant Cameron, Yulan Jiang, Kimberly Lee, Taofang Hu & Hitoshi Komuro

  2. European Institute for Peptide Research (IFRMP 23), Laboratory of Cellular and Molecular Neuroendocrinology, Institut National de la Santé et de la Recherche Médicale U-413, University of Rouen, Mont-Saint-Aignan, 76821, France

    Emilie Raoult, Ludovic Galas & David Vaudry

Authors
  1. Donald Bryant Cameron
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  2. Emilie Raoult
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  3. Ludovic Galas
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  4. Yulan Jiang
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  7. David Vaudry
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  8. Hitoshi Komuro
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Correspondence to Hitoshi Komuro.

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Cameron, D.B., Raoult, E., Galas, L. et al. Role of PACAP in Controlling Granule Cell Migration. Cerebellum 8, 433–440 (2009). https://doi.org/10.1007/s12311-009-0121-9

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  • DOI: https://doi.org/10.1007/s12311-009-0121-9

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