Skip to main content

Advertisement

SpringerLink
Log in

Hyperhomocysteinemia, as an Independent Risk Factor for Retinal Venous Occlusion in an Indian Population

  • Original Research
  • Published:
Indian Journal of Clinical Biochemistry Aims and scope Submit manuscript

Abstract

Total plasma homocysteine was analysed in 64 cases of retinal vein occlusion (RVO) of which 24 cases of central retinal vein occlusion (CRVO) and 40 cases of branch retinal vein occlusion (BRVO) and compared with 45 age and sex matched control. Homocysteine was significantly increased in RVO cases in respect to control (P < 0.001). Analysis also revealed that prevalence of rise of plasma homocysteine was more in cases of CRVO (OR = 13) than that of BRVO (OR = 5.03).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Kanski JJ. Clinical ophthalmology: a systematic approach. 6th ed. Philadelphia: Butterworth-Heinemann; 2007. p. 584–5.

    Google Scholar 

  2. Prisco D, Marcucci R. Retinal vein thrombosis: risk factors, pathogenesis and therapeutic approach. Pathophysiol Haemost Thromb. 2002;32:308–11.

    Article  PubMed  Google Scholar 

  3. Lahey JM, Kerarney JJ, Tunc M. Hypercoagulable states and central retinal vein occlusion. Curr Opin Pulm Med. 2003;9(5):385–92.

    Article  PubMed  Google Scholar 

  4. Boyd S, Owens D, Gin T, Bunce K, Sherafat H, Perry D, et al. Plasma homocysteine methylene tetrahydrofolate reductase C677T and factor II G2010A polymorphism, factor VIII and VWF in central retinal vein occlusion. Br J Ophthalmol. 2001;85:1313–5.

    Article  PubMed  CAS  Google Scholar 

  5. Genser D, Prachar H, Hauer R, Halbmayer M, Mlczoch J, Elmadfa I. Homocysteine, folate and vitamin B12 in patients with coronary heart disease. Ann Nutr Metab. 2006;50(5):413–9.

    Article  PubMed  CAS  Google Scholar 

  6. Pianka P, Almog Y, Man O, Goldstein M, Sela BA, Loewenstein A. Hyperhomocysteinemia in patients with nonarteric anterior ischemic optic neuropathy: central retinal artery occlusion and central retinal vein occlusion. Ophthalmology. 2000;107:1588–92.

    Article  PubMed  CAS  Google Scholar 

  7. Wenzler EM, Rademakers AJ, Boers GH, Cruysberg JR, Webers CA, Deutman AF. Hyperhomocysteine in retinal artery and retinal vein occlusion. Am J Ophthalmol. 1993;115:162–7.

    PubMed  CAS  Google Scholar 

  8. Brown BA, Marx JL, Ward TP, Hollifield RD, Dick JS, Brozetti JJ, et al. Homocysteine: a risk factor for retinal venous occlusive disease. Ophthalmology. 2002;109(2):287–90.

    Article  PubMed  Google Scholar 

  9. Lentz R. Mechanisms of homocysteine-induced atherothrombosis. J Thromb Haemost. 2005;3:1646–54.

    Article  PubMed  CAS  Google Scholar 

  10. Weiss N. Mechanisms of increased vascular oxidant stress in hyperhomocysteinemia and its impact on endothelial function. Curr Drug Metab. 2005;6(1):27–54.

    Article  PubMed  CAS  Google Scholar 

  11. Postea O, Krotz F, Henger A, Keller C, Weiss N. Stereospecific and redox-sensitive increase in monocyte adhesion to endothelial cells by homocysteine. Arterioscler Thromb Vasc Biol. 2006;26(3):508–13.

    Article  PubMed  CAS  Google Scholar 

  12. Jakubowski H. Pathophysiological consequences of homocysteine excess. J Nutr. 2006;136(Suppl 6):1741S–9S.

    PubMed  CAS  Google Scholar 

  13. Jacobsen DW, Catanescu O, Barbato JC. Molecular targeting by homocysteine: a mechanism for vascular pathogenesis. Clin Chem Lab Med. 2005;43(10):1076–83.

    Article  PubMed  CAS  Google Scholar 

  14. Selhub J. The many facets of hyperhomocysteinemia: studies from the Framingham cohorts. J Nutr. 2006;136:1726S–30S.

    PubMed  CAS  Google Scholar 

  15. Lattanzio R, Sampirtro F, Ramonia A, Fattorini A, Brancato R. Moderate hyperhomocysteinemia and early-onset central retinal vein occlusion. Retina. 2006;26(1):65–70.

    Article  PubMed  Google Scholar 

  16. Finkelstein JD. Inborn errors of sulfur-containing amino acid metabolism. J Nutr. 2006;136(suppl 6):1750S–4S.

    PubMed  CAS  Google Scholar 

  17. Pinna A, Carru C, Zinellu A, Dore S, Deiana L, Carta F. Plasma homocysteine and cysteine levels in retinal vein occlusion. Invest Ophthalmol Vis Sci. 2006;47(9):4067–71.

    Article  PubMed  Google Scholar 

  18. Chua B, Kifley A, Wong TY, Mitchell P. Homocysteine and retinal emboli the Blue Mountains eye study. Am J Ophthalmol. 2006;142(2):322–4.

    Article  PubMed  CAS  Google Scholar 

  19. Chau B, Kifley A, Wong TY, Mitchell P. Homocysteine and retinal vein occlusion: population based study. Am J Ophthalmol. 2005;139(1):181–2.

    Article  Google Scholar 

  20. Ueland PM, Refsum H, Stabler SP, Malinow MR, Andersson A, Allen RH, et al. Total homocysteine in plasma or serum: methods and clinical applications. Clin Chem. 1993;39:1764–79.

    PubMed  CAS  Google Scholar 

  21. Di Crecchio L, Parodi MB, Sanguinetti G, Iacono P, Ravalico G. Hyper homocysteinemia and the methylenetetrahydrofolate reductase 677C-T mutation in patients under 50 years of age affected by central retinal vein occlusion. Ophthalmology. 2004;111:940–5.

    Article  PubMed  Google Scholar 

  22. Gao W, Wang YS, Zhang P, Wang HY. Hyperhomocysteinemia and low plasma folate as risk factors for central retinal vein occlusion: a case-control study in a Chinese population. Graefes Arch Clin Exp Ophthalmol. 2006;244(10):1246–9.

    Article  PubMed  Google Scholar 

  23. Janssen MC, den Heijer M, Cruysberg JR, Wollersheim H, Bredie SJ. Retinal vein occlusion: a form of venous thrombosis or a complication of atherosclerosis?—a meta-analysis of thrombophilic factors. Thromb Haemost. 2005;93(6):1021–6.

    PubMed  CAS  Google Scholar 

  24. Cahil MT, Stinnett SS, Fekrat S. Meta-analysis of plasma homocysteine, serum folate, serum vitamin B12, and thermolabile MTHFR genotype as risk factors for retinal vascular occlusive disease. Am J Ophthalmol. 2003;136(6):1136–50.

    Article  Google Scholar 

  25. Dayal S, Devlin AM, McCaw RB, Liu ML, Arning E, Bottiglieri T, et al. Cerebral vascular dysfunction in methionine synthase-deficient mice. Circulation. 2005;112(5):737–44.

    Article  PubMed  CAS  Google Scholar 

  26. Poloschek CM, Fowler B, Unsold R, Lorenz B. Disturbed visual system function in methionine synthase deficiency. Graefes Arch Clin Exp Ophthalmol. 2005;243(5):497–500.

    Article  PubMed  CAS  Google Scholar 

  27. Kerkeni M, Tnani M, Chuniaud L, Miled A, Maaroufi K, Trivin F. Comparative study on in vitro effects of homocysteine thiolactone and homocysteine on HUVEC Cells: evidence for a stronger proapoptotic and proinflammative homocysteine thiolactone. Mol Cell Biochem. 2006;291(1–2):119–26.

    Article  PubMed  CAS  Google Scholar 

  28. Undas A, Brozek J, Szczeklik A. Homocysteine and thrombosis: from basic science to clinical evidence. Thromb Haemost. 2005;94(5):907–15.

    PubMed  CAS  Google Scholar 

Download references

Conflict of interest

Nil.

Author information

Authors and Affiliations

  1. Department of Biochemistry, RG Kar Medical College and Hospital, Kolkata, India

    Kapil D. Lahiri & Harendra N. Das

  2. Department of Ophthalmology, Regional Institute of Ophthalmology, Kolkata, India

    Jayanta Dutta & Himadri Datta

  3. 4/2 Shibchandra Sarbabhowma Lane, Baranagar, Kolkata, 700036, West Bengal, India

    Kapil D. Lahiri

Authors
  1. Kapil D. Lahiri
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jayanta Dutta
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Himadri Datta
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Harendra N. Das
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Kapil D. Lahiri.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lahiri, K.D., Dutta, J., Datta, H. et al. Hyperhomocysteinemia, as an Independent Risk Factor for Retinal Venous Occlusion in an Indian Population. Ind J Clin Biochem 28, 61–64 (2013). https://doi.org/10.1007/s12291-012-0238-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12291-012-0238-3

Keywords

Search

Navigation