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Therapeutic efficacy of different types of platelet concentrates in thrombocytopenic patients

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Indian Journal of Hematology and Blood Transfusion Aims and scope Submit manuscript

Abstract

Background

Platelet Rich Plasma-Platelet concentrate (PRP-PC), Buffy Coat poor-platelet concentrate (BCPC), and Apheresis — PC were prepared and their therapeutic efficacy were assessed in thrombocytopenic patients.

Study design and methods

PRP-PC and BC-PC were prepared from whole blood and Apheresis-PC by automated cell separator. The post transfusion efficacy of transfused platelets was assessed at 1 hour and 20 hours by corrected count increment (CCI) and percentage recovery (PR).

Results

A total of 60 patients’ (20 each for PRP-PC, BC-PC and Apheresis-PC) were enrolled in this study. Forty one patients received therapeutic and nineteen received prophylactic transfusion support. Patients with aplastic anemia 43% (25/60) and acute leukemia 38% (23/60) formed a majority of study population. Platelet dosage of patients’ received PRP-PC, BC-PC and apheresis-PC were 2.4±0.82 × 1011 (mean±SD), 2.2±0.83 × 1011 (mean±SD) and 4.14±1.82 × 1011 (mean±SD) and ranged from 1.16–4.11 × 1011, 1.04−4.20 × 1011 and 1.22−8.90 × 1011 respectively. There was significantly increase in inter-transfusion interval with Apheresis-PC than with PRP-PC and BC-PC recipients [(Mean±S.D.), 4.7±1.33 days Vs 2.7±0.82 days Vs 2.5±0.7 days respectively] (p < 0.05).

Conclusions

Patients transfused with apheresis-PC had received higher platelet dosage than PRP-PC and BC-PC and this difference was statistically significant (p < 0.001). The post transfusion platelet counts and increments at 1 hour and 20 hours were significantly higher with apheresis-PC than PRP-PC and BC-PC (p < 0.001). However, the corrected count increment (CCI) and percentage recovery (PR) in all three groups were comparable. There was significantly increase in inter-transfusion interval with apheresis-PC than PRPPC and BC-PC (p < 0.05).

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Abbreviations

RDP:

Random donor platelets

SDP:

single donor platelets

PRP-PC:

Platelet Rich Plasma-Platelet concentrate

BC-PC:

Buffy coat poor-platelet concentrate

PC:

platelet concentrate

CCI:

corrected count increment

PR:

percentage recovery.

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Authors and Affiliations

  1. Department of Transfusion Medicine, PGIMER, Chandigarh, India

    Ravindra Pratap Singh & Neelam Marwaha

  2. Department of Internal Medicine, PGIMER, Chandigarh, India

    Pankaj Malhotra

  3. Department of Hematology and Lab., PGIMER, Chandigarh, India

    Sumitra Dash

Authors
  1. Ravindra Pratap Singh
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  2. Neelam Marwaha
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  3. Pankaj Malhotra
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  4. Sumitra Dash
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Correspondence to Ravindra Pratap Singh.

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Singh, R.P., Marwaha, N., Malhotra, P. et al. Therapeutic efficacy of different types of platelet concentrates in thrombocytopenic patients. Indian J Hematol Blood Transfus 24, 16–22 (2008). https://doi.org/10.1007/s12288-008-0024-9

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  • DOI: https://doi.org/10.1007/s12288-008-0024-9

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