Abstract
Purpose
To compare the diagnostic ability of specimen radiography using digital mammography (DM) and digital breast tomosynthesis (DBT) for detecting breast cancer and evaluating its extension in the intraoperative specimen.
Methods
Sixty-five specimens from 65 women (median 62 years; range 34–86) obtained during breast-conserving surgery were prospectively investigated. Specimens underwent DM (25–40 kVp, 12–322 mA s) and DBT (25–34 kVp, 13–137 mA) in two orthogonal planes, anteroposterior (AP) and latero-lateral (LL). Images were interpreted by a radiologist to detect invasive lesions and their extensive intraductal components (EIC) or ductal carcinomas in situ (DCIS); afterwards, they were compared with histopathological findings.
Results
In AP views, 96 % of the invasive lesions were detected by both the methods. Of the EICs, 55 and 65 % were detected by DM and DBT, respectively (P = 0.61). Of the DICSs, 31 and 38 % were detected by DM and DBT, respectively (P > 0.99). In LL views, 71 and 13 % of the invasive lesions were detected by DBT and DM, respectively (P < 0.0001). Of the EICs, 42 and 10 % were detected by DBT and DM, respectively (P = 0.0078). Of the 13 DCISs, 42 and 8 % were detected by DBT and DM, respectively (P = 0.32). The whole lesion and contour could be delineated in 45 % by DBT and in 6.2 % by DM (P < 0.0001).
Conclusions
DBT could detect breast cancer more accurately than DM in LL views, indicating its potential to more precisely diagnose vertical invasion.
Similar content being viewed by others
References
McCormick JT, Keleher AJ, Tikhomirov VB, Budway RJ, Caushaj PF. Analysis of the use of specimen mammography in breast conservation therapy. Am J Surg. 2004;188:433–6.
Weber WP, Engelberger S, Viehl CT, Zanetti-Dallenbach R, Kuster S, Dirnhofer S, et al. Accuracy of frozen section analysis versus specimen radiography during breast-conserving surgery for nonpalpable lesions. World J Surg. 2008;32:2599–606.
Bathla L, Harris A, Davey M, Sharma P, Silva E. High resolution intra-operative two-dimensional specimen mammography and its impact on second operation for re-excision of positive margins at final pathology after breast conservation surgery. Am J Surg. 2011;202:387–94.
Hakim CM, Chough DM, Ganott MA, Sumkin JH, Zuley ML, Gur D. Digital breast tomosynthesis in the diagnostic environment: a subjective side-by-side review. AJR. 2010;195:172–6.
Baker JA, Lo JY. Breast tomosynthesis: state of the art and review of the literature. Acad Radiol. 2011;18:1298–310.
Urano M, Shiraki N, Hara M, Toyama T, Shibamoto Y (2014) Multi-detector row CT-guided marking technique for breast-conserving therapy of early breast cancer: margin positivity and local control rates. Breast Cancer (ahead of print).
Pleijhuis RG, Graafland M, De Vries J, Bart J, de Jong JS, van Dam GM. Obtaining adequate surgical margins in breast-conserving therapy for patients with early-stage breast cancer: current modalities and future directions. Ann Surg Oncol. 2009;16:2717–30.
Fusco R, Petrillo A, Catalano O, Sansone M, Granata V, Filice S, et al. Procedures for location of non-palpable breast lesions: a systematic review for the radiologist. Breast Cancer. 2014;21:522–31.
Haid A, Knauer M, Dunzinger S, Jasarevic Z, Köberle-Wührer R, Schuster A, et al. Intra-operative sonography: a valuable aid during breast conserving surgery for occult breast cancer. Ann Surg Oncol. 2007;14:3090–101.
Yingbing W, Ebuoma Lilian, Saksena Mansi, Liu B, Specht M, Rafferty E, et al. Clinical evaluation of a mobile digital specimen radiography system for intraoperative specimen verification. AJR. 2014;203:457–62.
Schulz-Wendtland R, Dilbat G, Bani M, Fasching PA, Heusinger K, Lux MP, et al. Full field digital mammography (FFDM) versus CMOS technology, specimen radiography system (SRS) and tomosynthesis (DBT)—which system can optimise surgical therapy? Geburtshilfe Frauenheilkd. 2013;73:422–7.
Wallace AM, Daniel BL, Jeffrey SS, Birdwell RL, Nowels KW, Dirbas FM, et al. Rates of re-excision for breast cancer after magnetic resonance imaging-guided bracket wire localization. J Am Coll Surg. 2005;200:527–37.
Ahmed M, van Hemelrijck M, Douek M. Systematic review of radioguided versus wire-guided localization in the treatment of non-palpable breast cancers. Breast Cancer Res Treat. 2013;140:241–52.
Tang R, Buckley JM, Fernandez L, Coopey S, Aftreth O, Michaelson J, et al. Micro-computed tomography (Micro-CT): a novel approach for intraoperative breast cancer specimen imaging. Breast Cancer Res Treat. 2013;139:311–6.
Uematsu T. The emerging role of breast tomosynthesis. Breast Cancer. 2013;20:204–12.
Tagliafico A, Tagliafico G, Astengo D, Airaldi S, Calabrese M, Houssami N. Comparative estimation of percentage breast tissue density for digital mammography, digital breast tomosynthesis, and magnetic resonance imaging. Breast Cancer Res Treat. 2013;138:311–7.
Takamoto Y, Tsunoda H, Kikuchi M, Hayashi N, Honda S, Koyama T, et al. Role of breast tomosynthesis in diagnosis of breast cancer for Japanese women. Asian Pac J Cancer Prev. 2013;14:3037–40.
Svahn TM, Chakraborty DP, Ikeda D, Zackrisson S, Do Y, Mattsson S, et al. Breast tomosynthesis and digital mammography: a comparison of diagnostic accuracy. Br J Radiol. 2012;85:1074–82.
Sechopoulos I, Suryanarayanan S, Vedantham S, D’Orsi C, Karellas A. Computation of the glandular radiation dose in digital tomosynthesis of the breast. Med Phys. 2007;34:221–32.
Wellings SR, Jensen HM, Marcum RG. An atlas of subgross pathology of the human breast with special reference to possible precancerous lesions. J Natl Cancer Inst. 1975;55:231–73.
Acknowledgments
The authors wish to thank radiology technologists at Nagoya City University Hospital for taking DM and DBT. No funding exists for this research.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
The authors declare that they have no conflicts of interest.
About this article
Cite this article
Urano, M., Shiraki, N., Kawai, T. et al. Digital mammography versus digital breast tomosynthesis for detection of breast cancer in the intraoperative specimen during breast-conserving surgery. Breast Cancer 23, 706–711 (2016). https://doi.org/10.1007/s12282-015-0628-5
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12282-015-0628-5