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Use of Antifungal Combination Therapy: Agents, Order, and Timing

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Abstract

Given the substantial morbidity and mortality related to invasive fungal infections, treatment with a combination of antifungal agents is often considered. A growing body of literature from in vitro studies, animal models, and clinical experience provides data evaluating this approach. This review describes combination antifungal strategies for the management of cryptococcal meningitis, invasive candidiasis, invasive aspergillosis, and rare mold infections. The potential effects that sequencing and timing have on the efficacy of such approaches are discussed, with a focus on recent clinical data in this arena.

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Disclosure

Dr. Johnson is a consultant for Enzon Pharmaceuticals and has received research grants from Merck, Pfizer, and Basilea Pharmaceutica. Dr. Perfect is a speaker and Principal Investigator for Astellas, Enzon, Merck, Pfizer, and Schering-Plough.

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  1. Campbell University College of Pharmacy & Health Sciences, Box 3306 DUMC, Durham, NC, 27710, USA

    Melissa D. Johnson

  2. Division of Infectious Diseases & International Health, Duke University Medical Center, Durham, NC, USA

    Melissa D. Johnson & John R. Perfect

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  1. Melissa D. Johnson
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Correspondence to Melissa D. Johnson.

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Johnson, M.D., Perfect, J.R. Use of Antifungal Combination Therapy: Agents, Order, and Timing. Curr Fungal Infect Rep 4, 87–95 (2010). https://doi.org/10.1007/s12281-010-0018-6

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