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Regulation of artificial supramolecular transmembrane signal transduction by selenium-containing artificial enzyme receptors

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Abstract

Signal transduction across lipid bilayers is of profound importance in biological processes. In biological systems, natural enzymes mediate biochemical effects by binding to substrates and facilitating the conversion of external signals into physiological responses. Sequential transmission of biological signals from one enzyme to the next promotes signal transduction with feedforward and feedback mechanisms. Reconstructing these processes in an artificial system provides potential applications and offers a new way to understand fundamental biological processes in depth. However, the design of artificial signal transduction systems regulated by artificial enzyme receptors in a predictable and intelligent manner remains a challenge. Herein, benefiting from the polarity-regulated characteristics of Se-containing compounds with artificial glutathione peroxidase (GPx) activity, we constructed an artificial transmembrane signaling receptor with a Se-containing GPx-like recognition head group, a membrane-anchoring group, and a pre-enzyme end group. The artificial supramolecular signal transduction system containing such signal transduction receptors extends the range of signaling systems based on enzyme regulation, which provides a new way to study natural signal processes in cells and artificially regulated biological processes.

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Acknowledgements

This work was supported by the National Key Research and Development Program of China (Nos. 2020YFA0908500 and 2018YFA0901600), and the National Natural Science Foundation of China (No. 22161142015).

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  1. Shengda Liu and Yunpeng Xing contributed equally to this work.

Authors and Affiliations

  1. Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou, 311121, China

    Shengda Liu, Tengfei Yan, Jiayun Xu, Tingting Wang & Junqiu Liu

  2. State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun, 130012, China

    Yunpeng Xing, Yijia Li, Ruizhen Tian & Jinxing Hou

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  1. Shengda Liu
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Correspondence to Tingting Wang or Junqiu Liu.

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Regulation of artificial supramolecular transmembrane signal transduction by selenium-containing artificial enzyme receptors

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Liu, S., Xing, Y., Yan, T. et al. Regulation of artificial supramolecular transmembrane signal transduction by selenium-containing artificial enzyme receptors. Nano Res. 16, 964–969 (2023). https://doi.org/10.1007/s12274-022-4814-4

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  • DOI: https://doi.org/10.1007/s12274-022-4814-4

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