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Recent deveolpment of multifunctional responsive gas-releasing nanoplatforms for tumor therapeutic application

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Abstract

Gas therapy (GT) exhibits great potential for clinical application due to its high therapeutic efficiency, low systemic side effects, and biosafety, thereinto, a multifunctional nanoplatform is generally needed for controllable gas release and precise delivery to tumor tissue. In this review, the recent development of multifunctional nanoplatforms for efficient tumor delivery of stimuli-responsive gas-releasing molecules (GRMs), which could be triggered by either exogenous physical or endogenous tumor microenvironment (TME) is summarized. The reported therapeutic gas molecules, including oxygen (O2), hydrogen sulfide (H2S), nitric oxide (NO), hydrogen (H2), and carbon monoxide (CO), etc., could directly influence or change the pathological status. Additionally, abundant nanocarriers have been employed for gas delivery into cancer region, such as mesoporous silica nanoparticles (MSNs), metal-organic frameworks (MOFs), two-dimensional (2D) nanomaterials, and liposomes, as well as non-nanocarriers including inorganic and organic nanoparticles. In the end, the outlooks of current challenges of GT and GRMs delivery nanoplatforms as well as the prospects of future clinical applications are proposed.

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Acknowledgments

This work was supported by the National Key R&D Program of China (No. 2021YFB3801001), the National Natural Science Foundation of China (Nos. 32030061 and 81720108023), and the Key Program for Basic Research of Shanghai (Nos. 19JC1415600 and 21JC1406000).

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  1. State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, China

    Zebin Yang & Hangrong Chen

  2. School of Chemical Science and Engineering, Tongji University, Shanghai, 200092, China

    Zebin Yang

  3. School of Chemistry and Materials Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, 310024, China

    Hangrong Chen

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  1. Zebin Yang
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Correspondence to Hangrong Chen.

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Yang, Z., Chen, H. Recent deveolpment of multifunctional responsive gas-releasing nanoplatforms for tumor therapeutic application. Nano Res. 16, 3924–3938 (2023). https://doi.org/10.1007/s12274-022-4473-5

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